Tumour Heterogeneity and Clonal Evolution in Nasopharyngeal Carcinoma

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Grant Data
Project Title
Tumour Heterogeneity and Clonal Evolution in Nasopharyngeal Carcinoma
Principal Investigator
Professor Lee, Victor Ho Fun   (Principal Investigator (PI))
Co-Investigator(s)
Professor Guan Xin-Yuan   (Co-Investigator)
Dr Kam Ngar Woon   (Co-Investigator)
Professor Kwong Dora Lai Wan   (Co-Investigator)
Dr Lam Ka On   (Co-Investigator)
Dr Lo Wing Ip Anthony   (Co-Investigator)
Duration
24
Start Date
2019-01-01
Amount
600000
Conference Title
Tumour Heterogeneity and Clonal Evolution in Nasopharyngeal Carcinoma
Keywords
Clonal evolution, Nasopharyngeal carcinoma, Tumour heterogeneity, whole-exome sequencing
Discipline
CancerGenomic Biology
Panel
Biology and Medicine (M)
HKU Project Code
17106718
Grant Type
General Research Fund (GRF)
Funding Year
2018
Status
Completed
Objectives
1 To characterise genomic and transcriptomic intratumour heterogeneity and clonal evolution in NPC at diagnosis, metastasis and relapse through multi-region next generation sequencings 2 To investigate the correlation between the identified genetic alteration(s) and evolution trajectory in this study with clinicopathological data and survival outcomes