Targeting BCL6 in diffuse large B-cell lymphoma with arsenic trioxide

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Grant Data
Project Title
Targeting BCL6 in diffuse large B-cell lymphoma with arsenic trioxide
Principal Investigator
Professor Tse, Eric Wai Choi   (Principal Investigator (PI))
Co-Investigator(s)
Professor Kwong Yok Lam   (Co-Investigator)
Duration
30
Start Date
2018-08-20
Amount
652788
Conference Title
Targeting BCL6 in diffuse large B-cell lymphoma with arsenic trioxide
Presentation Title
Keywords
arsenic trioxide, BCL6, lymphoma
Discipline
Blood/Hematology,Cancer
Panel
Biology and Medicine (M)
HKU Project Code
17116618
Grant Type
General Research Fund (GRF)
Funding Year
2018
Status
Completed
Objectives
1 To examine if BCL6 is a target of As2O3 in DLBCL 2 To examine the mechanisms of As2O3-induced degradation of BCL6 in DLBCL 3 To examine the effect of As2O3 on DLBCL using primary human samples and mouse model