The clinical safety and efficacy of Zoledronic acid for treatment of chronic low back pain due to Modic changes: a parallel, double-blinded, randomized controlled trial

View Statistics Email Alert RSS Feed

Grant Data
Project Title
The clinical safety and efficacy of Zoledronic acid for treatment of chronic low back pain due to Modic changes: a parallel, double-blinded, randomized controlled trial
Principal Investigator
Dr Shea, Graham Ka Hon   (Principal Investigator (PI))
Co-Investigator(s)
Dr Cheung Jason Pui Yin   (Co-Investigator)
Professor Karppinen Jaro   (Co-Investigator)
Dr SAMARTZIS Dino   (Co-Investigator)
Duration
34
Start Date
2018-07-01
Amount
562374
Conference Title
The clinical safety and efficacy of Zoledronic acid for treatment of chronic low back pain due to Modic changes: a parallel, double-blinded, randomized controlled trial
Presentation Title
Keywords
Chronic pain, Degenerative Disc, Low back pain, Modic Changes, Zoledronic acid
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
05162286
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2017
Status
Completed
Objectives
Chronic low back pain (LBP) is the world’s most disabling condition. Modic changes (MC) on MRI are highly associated with the development and severity of chronic LBP. Non-invasive and economical treatment of chronic LBP patients with MC is needed. As such, this study will evaluate the safety and efficacy of orally administered 50 mg of Zoledronic acid (ZA) once a week for 6 weeks to placebo among patients with chronic LBP and Modic changes on MRI.