Effects on induction of viral lytic cycle in Epstein-Barr virus-associated epithelial malignancies by combining histone deacetylase inhibitor and a novel organic compound
Grant Data
Project Title
Effects on induction of viral lytic cycle in Epstein-Barr virus-associated epithelial malignancies by combining histone deacetylase inhibitor and a novel organic compound
Principal Investigator
Dr Chiang, Alan Kwok Shing
(Principal Investigator (PI))
Co-Investigator(s)
Dr Hui Kwai Fung
(Co-Investigator)
Duration
36
Start Date
2018-06-01
Amount
1195048
Conference Title
Effects on induction of viral lytic cycle in Epstein-Barr virus-associated epithelial malignancies by combining histone deacetylase inhibitor and a novel organic compound
Presentation Title
Keywords
Epstein-Barr virus, High-throughput, Histone deacetylase, JNK, Lytic cycle reactivation, PKC
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
17160712
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2017
Status
Completed
Objectives
Objective: We aim to delineate the role of JNK signaling in lytic reactivation by E11 and investigate the effects of combining E11 and HDACI in inducing EBV lytic cycle.