The Anticancer Effect of Chinese Medicine Formulation Olive Branch-1

Professor Che, Chi Ming   (Project Coordinator (PC))

Dr Fung Eva Yi Man   (Co-Investigator)

Dr Lok Chun Nam   (Co-Investigator)

Dr Wo Henry Lam Kee   (Co-principal investigator)

Dr Sy Lai King   (Co-Investigator)

24

2018-01-01

2019-12-31

2910000

The Anticancer Effect of Chinese Medicine Formulation Olive Branch-1

Anticancer Effect, Chinese Medicine, Formulation, Olive Branch-1

Biochemistry

Physical Sciences (P)

UIM/327

Matching Grant for Joint Research

2017

Completed

Olive Branch-1 (OB-1) is a formulation containing Chinese medicines clinically used for cancer treatment. It has been prescribed by physicians for more than 17 years notably effective for lung, colorectal and lymphatic cancers. The ultimate objective of R&D work of OB-1 is to register and commercialize OB-1 as a proprietary Chinese medicine (pCm) in Hong Kong and other countries for treating cancer. The anticancer effect of OB-1 will primarily be investigated by five major approaches: (a) establish chemical fingerprint and quality evaluation of OB-1 by UPLC-MS-QTOF for identification and quality control; (b) explore the possibility of streamlining the OB-1 formulation without affecting or even enhancing its efficacy; (c) investigate the in vivo effects of OB-1 in animal models; (d) use molecular biology, transcriptomic and proteomic techniques to study the mechanistic action of OB-1 and (e) study the immunomodulatory effects of OB-1. The deliverables brought by the proposed project will steer participating company to make strategic investment on R&D projects including the proposed one. The benefit brought by the project not only on promoting university's and company's technological level but also on giving innovative insights to other Chinese medicine formulations such as OB-2 and OB-3, which have been lined up to be developed.