Holocentric but not everywhere on the chromosome: How and where does histone chaperone RbAp46/48/LIN-53 assemble Centromeric Protein A (CENP-A/HCP-3) in Caenorhabditis elegans?
Grant Data
Project Title
Holocentric but not everywhere on the chromosome: How and where does histone chaperone RbAp46/48/LIN-53 assemble Centromeric Protein A (CENP-A/HCP-3) in Caenorhabditis elegans?
Principal Investigator
Dr Yuen, Karen Wing Yee
(Principal Investigator (PI))
Co-Investigator(s)
Dr Zhao Zhongying
(Co-Investigator)
Professor Li Xiang David
(Co-Investigator)
Duration
36
Start Date
2018-01-01
Amount
1221692
Conference Title
Holocentric but not everywhere on the chromosome: How and where does histone chaperone RbAp46/48/LIN-53 assemble Centromeric Protein A (CENP-A/HCP-3) in Caenorhabditis elegans?
Presentation Title
Keywords
Centromere, Chromosome segregation, Epigenetics, Histone chaperone, Kinetochore
Discipline
Cell Biology,Genomic Biology
Panel
Biology and Medicine (M)
HKU Project Code
17126717
Grant Type
General Research Fund (GRF)
Funding Year
2017
Status
Completed
Objectives
1 Determine how histone chaperone LIN-53 assembles HCP-3 to holocentromeric chromatin in vivo 2 Elucidate the physical interaction between LIN-53 and HCP-3 in vitro 3 Decipher the effect of LIN-53 and transcription on the genome-wide localization of holocentromeres by DNA Adenine Methyltransferase Identification (DamID)