Epigenetic regulation of C/EBP-epsilon enhancer activity in MLL-rearranged leukemia
Grant Data
Project Title
Epigenetic regulation of C/EBP-epsilon enhancer activity in MLL-rearranged leukemia
Principal Investigator
Dr Ng, Ray Kit
(Principal Investigator (PI))
Co-Investigator(s)
Professor Leung Anskar Yu Hung
(Co-Investigator)
Duration
24
Start Date
2017-10-01
Amount
972925
Conference Title
Epigenetic regulation of C/EBP-epsilon enhancer activity in MLL-rearranged leukemia
Presentation Title
Keywords
C/EBP-epsilon, differentiation, DNA methylation, enhancer, MLL-rearranged leukemia
Discipline
Blood/Hematology,Gene Regulation
Panel
Biology and Medicine (M)
HKU Project Code
17114117
Grant Type
General Research Fund (GRF)
Funding Year
2017
Status
Completed
Objectives
1 To identify the enhancer regions of C/EBPe in MLL-rearranged leukemia. 2 To investigate the chromosomal interactions mediated by C/EBPe enhancers and the associated key transcription factors. 3 To delineate the functional correlation between aberrant DNA methylation and C/EBPe enhancer activity in leukemia cell differentiation.
All Publications
| Title | Author(s) | Issue Date | |
|---|---|---|---|
Aberrant DNA Methylation in Acute Myeloid Leukemia and Its Clinical Implications Journal:International Journal of Molecular Sciences | 2019 |