A Phase 1b Study of Polo-like Kinase 4 inhibitor CFI-400945 in Advanced Hepatocellular Carcinoma

View Statistics Email Alert RSS Feed

Grant Data
Project Title
A Phase 1b Study of Polo-like Kinase 4 inhibitor CFI-400945 in Advanced Hepatocellular Carcinoma
Principal Investigator
Dr Yau, Thomas Chung Cheung   (Principal Investigator (PI))
Co-Investigator(s)
Dr Chiu Wing Yan Joanne   (Co-Investigator)
Dr Wong Carmen Chak Lui   (Co-Investigator)
Duration
36
Start Date
2018-01-01
Amount
854241
Conference Title
A Phase 1b Study of Polo-like Kinase 4 inhibitor CFI-400945 in Advanced Hepatocellular Carcinoma
Presentation Title
Keywords
CFI-400945, Hepatocellular Carcinoma, Phase 1, Polo-like Kinase 4 inhibitor
Discipline
Clinical Trials,Cancer
Panel
Biology and Medicine (M)
HKU Project Code
17618117
Grant Type
General Research Fund (GRF)
Funding Year
2017
Status
Completed
Objectives
1 Establish the safety, dose limiting toxicity (DLT) and maximum tolerated dose (MTD) of CFI-400945 in advanced HCC population 2 Characterize CFI-400945 pharmacokinetics in advanced HCC population 3 Evaluate preliminary anti-tumor activity of CFI-400945 and explore its association with exploratory biomarkers(PTEN) 4 Assess the progression free survival and overall survival of advanced HCC patients on CFI-400945