The role of mitochondrial regulation in marginal graft injury after living donor liver transplantation

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Grant Data
Project Title
The role of mitochondrial regulation in marginal graft injury after living donor liver transplantation
Principal Investigator
Professor Man, Kwan   (Principal Investigator (PI))
Co-Investigator(s)
Professor Lo Chung Mau   (Co-Investigator)
Duration
42
Start Date
2018-01-01
Amount
1403701
Conference Title
The role of mitochondrial regulation in marginal graft injury after living donor liver transplantation
Keywords
Animal models, Liver transplantation, Marginal liver graft injury, Mitochondrial biogeneses
Discipline
Surgical ResearchTransplantation
Panel
Biology and Medicine (M)
HKU Project Code
17122517
Grant Type
General Research Fund (GRF)
Funding Year
2017
Status
Completed
Objectives
1 To investigate the correlation between mitochondrial impairment and marginal graft injury both in clinical transplantation cohort and rat liver transplantation model using small-for-size fatty liver graft 2 To study the role and regulating mechanism of mitochondrial function and biogenesis on marginal liver graft injury through a series of in vivo (transgenic mice models) and in vitro experiments 3 To explore the potential therapeutics to attenuate hepatic ischemia reperfusion injury by promoting mitochondrial function and biogenesis in animal models