Lipocalin-2: a key mediator of tissue fibrosis in obesity-associated cardiometabolic renal syndrome

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Grant Data
Project Title
Lipocalin-2: a key mediator of tissue fibrosis in obesity-associated cardiometabolic renal syndrome
Principal Investigator
Professor Wang, Yu   (Principal Investigator (PI))
Co-Investigator(s)
Duration
42
Start Date
2018-01-01
Amount
1225400
Conference Title
Lipocalin-2: a key mediator of tissue fibrosis in obesity-associated cardiometabolic renal syndrome
Presentation Title
Keywords
cardiometabolic renal syndrome, lipocalin-2, mesothelial cells, obesity, tissue fibrosis
Discipline
Cardiovascular Research,Disease Model Development
Panel
Biology and Medicine (M)
HKU Project Code
17117017
Grant Type
General Research Fund (GRF)
Funding Year
2017
Status
Completed
Objectives
1 To investigate whether or not selectively abolishing lipocalin-2 expression in mesothelial (progenitor) cells of the pericardium prevents cardiac fibrosis in mice with CMRS 2 To explore the role and cellular source of lipocalin-2 in mediating glomerular injury during the development of CMRS in mice