Therapeutic potential of regulatory T cells in limiting HIV reservoir in the brain without triggering detrimental neuroinflammation
Grant Data
Project Title
Therapeutic potential of regulatory T cells in limiting HIV reservoir in the brain without triggering detrimental neuroinflammation
Principal Investigator
Dr Liu, Li
(Principal Investigator (PI))
Co-Investigator(s)
Professor Chen Zhiwei
(Co-Investigator)
Duration
24
Start Date
2017-04-01
Completion Date
2020-04-24
Amount
1196064
Conference Title
Therapeutic potential of regulatory T cells in limiting HIV reservoir in the brain without triggering detrimental neuroinflammation
Keywords
cytotoxic T lymphocyte, HIV/AIDS, neuroinflammation, regulatory T cell, viral reservoir
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
16150662
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2016
Status
Completed
Objectives
This study aims to determine antigen-specific Tregs have the potential to limit HIV reservoir in the brain by direct killing of HIV-infected macrophages, with the ability to avoid triggering detrimental neuroinflammation by producing antiinflammatory factors.