Optogenetic Functional MRI Dissection of Long-Range Brain Networks
Grant Data
Project Title
Optogenetic Functional MRI Dissection of Long-Range Brain Networks
Principal Investigator
Professor Wu, Ed Xuekui
(Project Coordinator (PC))
Co-Investigator(s)
Professor He Jufang
(Co-principal investigator)
Professor Khong Pek Lan
(Co-principal investigator)
Dr Jiang Lijun
(Co-principal investigator)
Dr Lim Lee Wei
(Co-principal investigator)
Professor Yung Wing Ho
(Co-principal investigator)
Professor Tsia Kevin Kin Man
(Co-principal investigator)
Professor Chan Ying Shing
(Co-principal investigator)
Professor Lai Sau Wan Cora
(Co-principal investigator)
Duration
42
Start Date
2017-04-01
Completion Date
2020-09-30
Amount
6770835
Conference Title
Optogenetic Functional MRI Dissection of Long-Range Brain Networks
Keywords
brain connectivity, brain networks, Functional MRI, MRI, optogenetics
Discipline
ImagingBiological Imaging
Panel
Engineering (E)
HKU Project Code
C7048-16G
Grant Type
Collaborative Research Fund (CRF) - Group Research Project
Funding Year
2016
Status
Completed
Objectives
Develop and advance the state-of-the-art optogenetic fMRI technology that integrates cell-type specific and spatiotemporally precise optogenetic neuromodulation with fMRI of the whole brain activities in rat models with high sensitivity, spatial and temporal resolution on a 7 Tesla MRI platform. Investigate thalamo-cortical (T-C) and hippocampal-cortical (H-C) networks for their dynamic response properties using (i) og-fMRI and (ii) multi-site electrophysiological recording/analysis as guided by og-fMRI results. Investigate functional effects of low-frequency optogenetic neuromodulation within T-C and H-C networks on (i) brain responses to external sensory (visual, somatosensory or auditory) stimuli, and (ii) underlying neurophysiology.