Immortalization of nasopharyngeal epithelial cells by the EBV-encoded LMP1

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Grant Data
Project Title
Immortalization of nasopharyngeal epithelial cells by the EBV-encoded LMP1
Principal Investigator
Professor Tsao, George Sai Wah   (Principal Investigator (PI))
Co-Investigator(s)
Professor Lo Kwok Wai   (Co-Investigator)
Duration
42
Start Date
2016-07-01
Amount
1256240
Conference Title
Immortalization of nasopharyngeal epithelial cells by the EBV-encoded LMP1
Keywords
EBV infection, Immortalization, LMP1, Nasopharyngeal carcinoma
Discipline
CancerCell Biology
Panel
Biology and Medicine (M)
HKU Project Code
17161116
Grant Type
General Research Fund (GRF)
Funding Year
2016
Status
Completed
Objectives
1 To define the key functional domains and signaling pathways of LMP1 involved in the immortalization of primary nasopharyngeal epithelial (NPE) cells. 2 To determine the role of EGFR overexpression in LMP1 immortalization of NPE cells 3 To define signaling events involved in LMP1 inhibition of AMPK activity and its impact on mTORC1 activation and immortalization. 4 To investigate the activation mechanisms of mTORC2 by LMP1 and their involvements in immortalization