New Mechanistic Insights into DNMT1-mediated Maintenance DNA Methylation

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Grant Data
Project Title
New Mechanistic Insights into DNMT1-mediated Maintenance DNA Methylation
Principal Investigator
Dr Qian, Chengmin   (Principal Investigator (PI))
Co-Investigator(s)
Professor Zhou Zhongjun   (Co-Investigator)
Duration
36
Start Date
2016-09-01
Amount
1154550
Conference Title
New Mechanistic Insights into DNMT1-mediated Maintenance DNA Methylation
Presentation Title
Keywords
DNA methylation, DNMT1, histone ubiquitination, UHRF1, X-ray crystallography
Discipline
Structural Biology,Biochemistry
Panel
Biology and Medicine (M)
HKU Project Code
17160016
Grant Type
General Research Fund (GRF)
Funding Year
2016
Status
Completed
Objectives
1 To determine the crystal structure of DNMT1 with ubiquitin. 2 To characterize the molecular interaction of DNMT1 with UHRF1. 3 To evaluate DNA methylation status in UHRF1-/- ES cells expressing UHRF1 mutants.