SIRT6 deacetylates p53 to modulate cellular senescence and aging
Grant Data
Project Title
SIRT6 deacetylates p53 to modulate cellular senescence and aging
Principal Investigator
Professor Zhou, Zhongjun
(Principal Investigator (PI))
Duration
36
Start Date
2016-07-01
Amount
1141440
Conference Title
SIRT6 deacetylates p53 to modulate cellular senescence and aging
Presentation Title
Keywords
acetylation, Aging, p53, senescence, SIRT6
Discipline
Ageing,Genomic Biology
Panel
Biology and Medicine (M)
HKU Project Code
17123816
Grant Type
General Research Fund (GRF)
Funding Year
2016
Status
Completed
Objectives
1 To determine the major types and sites of modifications on p53 protein that are modified by SIRT6 2 To determine the contribution of up-regulation of p53 signaling to premature aging in Sirt6 deficient mice 3 To investigate the molecular mechanisms underlying the lifespan extension in Sirt6-/- mice by p53 deficiency