Timely resetting mitochondrial function by SIRT1 in adipose tissue determines the pace of metabolic ageing in mice
Grant Data
Project Title
Timely resetting mitochondrial function by SIRT1 in adipose tissue determines the pace of metabolic ageing in mice
Principal Investigator
Professor Wang, Yu
(Principal Investigator (PI))
Duration
48
Start Date
2017-01-01
Amount
1355707
Conference Title
Timely resetting mitochondrial function by SIRT1 in adipose tissue determines the pace of metabolic ageing in mice
Presentation Title
Keywords
adipose tissue, metabolic ageing, mitochondria, mitochondrial stress responses, SIRT1
Discipline
Others - Medicine, Dentistry and Health,Ageing
Panel
Biology and Medicine (M)
HKU Project Code
17153016
Grant Type
General Research Fund (GRF)
Funding Year
2016
Status
Completed
Objectives
1 To investigate how mitohormesis is invoked by overexpression of human SIRT1 in adipose tissue and whether modulation of mitohormesis early in life compromises the metabolically healthy ageing phenotype of Adipo-SIRT1. 2 To elucidate the molecular mechanisms underlying the decreased Complex-I activities and the dynamic mitochondrial remodeling in adipose tissues of Adipo-SIRT1 mice.