Automated bioreactors for expanding and monitoring mesenchymal stem cells
Grant Data
Project Title
Automated bioreactors for expanding and monitoring mesenchymal stem cells
Principal Investigator
Professor Chan, Godfrey Chi Fung
(Project Coordinator (PC))
Co-Investigator(s)
Professor Cui Zhanfeng
(Co-Investigator)
Dr Li Chun Bong
(Co-Investigator)
Dr Deng Ruixia
(Co-Investigator)
Mr Chan Kwong Chung Bernard
(Co-Investigator)
Duration
30
Start Date
2016-10-01
Amount
4398003
Conference Title
Automated bioreactors for expanding and monitoring mesenchymal stem cells
Keywords
Automated bioreactors, mesenchymal stem cells
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
UIM/287
Grant Type
Matching Grant for Joint Research
Funding Year
2015
Status
Completed
Objectives
The overall aim of this project is the creation of a standardised modular bioprocessing bioreactor system for mesenchymal stem cell (MSC) ex-vivo expansion, with controlled differentiation and genetic stability. The cellular products should fulfil the scientific, clinical, and regulatory standard for clinical use. We will achieve this objective by fulfilling the following aims: 1. Establish design criteria for an adaptable, user-friendly bioreactor system 2. Development of design methodology protocol 3. Design, fabrication, and assembly of the standardized modular bioreactor systems 4. Operational evaluation of the development bioreactor systems using human MSC 5. Assessment of bioreactor efficacy for clinical and commercial applications