Antimicrobial activities of bismuth complexes beyond H. pylori
Grant Data
Project Title
Antimicrobial activities of bismuth complexes beyond H. pylori
Principal Investigator
Professor Sun, Hongzhe
(Principal Investigator (PI))
Co-Investigator(s)
Professor Wang Junwen John
(Co-Investigator)
Duration
36
Start Date
2015-11-01
Amount
1058362
Conference Title
Antimicrobial activities of bismuth complexes beyond H. pylori
Presentation Title
Keywords
antimicrobial, bismuth, metallomics/ metalloproteomics, protein, structure and function
Discipline
Chemical Sciences
Panel
Physical Sciences (P)
HKU Project Code
17305415
Grant Type
General Research Fund (GRF)
Funding Year
2015
Status
Completed
Objectives
1 To synthesize of bismuth complexes and prepare for a compound bank 2 To screen bismuth complexes against Pseudomonas aeruginosa, Burkholderia cepacia, MRSA and relevant virulent bacteria, and to use gallium analogues for comparison 3 To study the mechanisms of action of lead antimicrobial metallo-agents via an integrative metallomic and metalloproteomic approach 4 To analyze those identified proteins by bio-informatics; and to initially validate certain key proteins (and enzymes) through bioassay 5 To educate young generation on frontier research of medicinal chemistry particularly metal ions in medicine, and to nurture innovative economy locally