Role of costimulatory molecule CD137 in the antiviral activity of human gammadelta-T cells against influenza virus

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Grant Data
Project Title
Role of costimulatory molecule CD137 in the antiviral activity of human gammadelta-T cells against influenza virus
Principal Investigator
Professor Tu, Wenwei   (Principal Investigator (PI))
Co-Investigator(s)
Duration
24
Start Date
2016-01-01
Amount
1022409
Conference Title
Role of costimulatory molecule CD137 in the antiviral activity of human gammadelta-T cells against influenza virus
Presentation Title
Keywords
CD137, gammadelta-T cells, influenza virus, innate immunity
Discipline
Allergy/Immunology
Panel
Biology and Medicine (M)
HKU Project Code
17115015
Grant Type
General Research Fund (GRF)
Funding Year
2015
Status
Completed
Objectives
1 To determine the kinetics of CD137/CD137L expression in human gammadelta-T cells and influenza virus-infected cells. 2 To determine whether CD137 signal can stimulate the activation and expansion of human gammadelta-T cells in vitro. 3 To determine whether CD137 signal can increase the antiviral activity of human gammadelta-T cells against influenza virus in vitro. 4 To determine whether CD137 signal can stimulate the activation and expansion of human gammadelta-T cells in vivo. 5 To determine whether CD137 signal can enhance antiviral activity of human gammadelta-T cells against influenza virus in vivo.