HKU Scholars Hub: Project

Discovery and Pre-Clinical Evaluation of Promising Metal-Based Anti-Cancer Drug Leads

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Grant Data

Project Title

Discovery and Pre-Clinical Evaluation of Promising Metal-Based Anti-Cancer Drug Leads

Principal Investigator

Professor Che, Chi Ming (Principal Investigator (PI))

Co-Investigator(s)

Dr Ma Dik Lung (Co-Investigator)

Dr Sun Wai Yin Raymond (Deputy project coordinator)

Professor Lau Tai Chu (Co-Investigator)

Professor Wang Yu (Co-Investigator)

Dr Siu Fung Ming Annie (Co-Investigator)

Dr Lau Chi Keung (Co-Investigator)

Professor Lin Marie Chia-Mi (Co-Investigator)

Dr Leung Chung Hang (Co-Investigator)

Duration

Start Date

2010-03-01

Amount

8999900

Conference Title

Discovery and Pre-Clinical Evaluation of Promising Metal-Based Anti-Cancer Drug Leads

Presentation Title

Keywords

Metal-Based Anti-Cancer Drug

Discipline

Pharmacology/Toxicology

Panel

Physical Sciences (P)

HKU Project Code

ITS/134/09FP

Grant Type

Innovation and Technology Support Programme (Tier 2)

Funding Year

2009

Status

Completed

All Publications

Title	Author(s)	Issue Date	Views
Specific blocking of CREB/DNA binding by cyclometalated platinum(II) complexes Journal:Angewandte Chemie - International Edition	Wang, P Leung, CH Ma, DL Sun, RWY Yan, SC Chen, QS Che, CM	2011
Osmium(vi) complexes as a new class of potential anti-cancer agents Journal:Chemical Communications	Ni, WX Man, WL Cheung, MTW Sun, RWY Shu, YL Lam, YW Che, CM Lau, TC	2011
Organoplatinum(II) complexes with nucleobase motifs as inhibitors of human topoisomerase II catalytic activity Journal:Chemistry - An Asian Journal	Wang, P Leung, CH Ma, DL Lu, W Che, CM	2010	148
Luminescent cyclometalated platinum(II) complexes containing N-heterocyclic carbene ligands with potent in vitro and in vivo anti-cancer properties accumulate in cytoplasmic structures of cancer cells Journal:Chemical Science	Sun, RWY Chow, ALF Li, XH Yan, JJ Chui, SSY Che, CM	2011	202
Cyclometalated platinum(ii) complexes as topoisomerase IIα poisons Journal:Chemical Communications	Liu, J Leung, CH Chow, ALF Sun, RWY Yan, SC Che, CM	2011	166
Anticancer gold(I)-phosphine complexes as potent autophagy-inducing agents Journal:Chemical Communications	Tian, S Siu, FM Kui, SCF Lok, CN Che, CM	2011	350
Anticancer dirhodium(ii,ii) carboxylates as potent inhibitors of ubiquitin-proteasome system Journal:Chemical Science	Siu, FM Lin, IWS Yan, K Lok, CN Low, KH Leung, TYC Lam, TL Che, CM	2012	227