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Showing results 1 to 8 of 8

	Title	Author(s)	Issue Date
	Design and optimization of (3-aryl-1H-indazol-6-yl)spiro[cyclopropane-1,3′-indolin]-2′-ones as potent PLK4 inhibitors with oral antitumor efficacy Journal:Bioorganic and Medicinal Chemistry Letters	Li, Sze Wan Liu, Yong Sampson, Peter B.Patel, Narendra Kumar Forrest, Bryan T.Edwards, Louise Laufer, Radoslaw Feher, Miklos Ban, Fuqiang Awrey, Donald E.Hodgson, Richard Beletskaya, Irina Mao, Guodong Mason, Jacqueline M.Wei, Xin Luo, Xunyi Kiarash, Reza Green, Erin Mak, Tak W.Pan, Guohua Pauls, Henry W.	2016
	Discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamides as novel, highly potent and selective, orally bioavailable inhibitors of Tyrosine Threonine Kinase, TTK Journal:Bioorganic and Medicinal Chemistry Letters	Laufer, Radoslaw Li, Sze Wan Liu, Yong Ng, Grace Lang, Yunhui Feher, Miklos Brokx, Richard Beletskaya, Irina Hodgson, Richard Mao, Guodong Plotnikova, Olga Awrey, Donald E.Mason, Jacqueline M.Wei, Xin Lin, Dan Chi Chia Che, Yi Kiarash, Reza Madeira, Brian Fletcher, Graham C.Mak, Tak W.Bray, Mark R.Pauls, Henry W.	2016
	Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides Journal:Bioorganic and Medicinal Chemistry	Laufer, Radoslaw Ng, Grace Liu, Yong Patel, Narendra Kumar B.Edwards, Louise G.Lang, Yunhui Li, Sze Wan Feher, Miklos Awrey, Don E.Leung, Genie Beletskaya, Irina Plotnikova, Olga Mason, Jacqueline M.Hodgson, Richard Wei, Xin Mao, Guodong Luo, Xunyi Huang, Ping Green, Erin Kiarash, Reza Lin, Dan Chi Chia Harris-Brandts, Marees Ban, Fuqiang Nadeem, Vincent Mak, Tak W.Pan, Guohua J.Qiu, Wei Chirgadze, Nickolay Y.Pauls, Henry W.	2014
	Discovery of Pyrazolo[1,5-a]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent Journal:ACS Medicinal Chemistry Letters	Liu, Yong Laufer, Radoslaw Patel, Narendra Kumar Ng, Grace Sampson, Peter B.Li, Sze Wan Lang, Yunhui Feher, Miklos Brokx, Richard Beletskaya, Irina Hodgson, Richard Plotnikova, Olga Awrey, Donald E.Qiu, Wei Chirgadze, Nickolay Y.Mason, Jacqueline M.Wei, Xin Lin, Dan Chi Chia Che, Yi Kiarash, Reza Fletcher, Graham C.Mak, Tak W.Bray, Mark R.Pauls, Henry W.	2016
	Functional characterization of CFI-402257, a potent and selective Mps1/TTK kinase inhibitor, for the treatment of cancer Journal:Proceedings of the National Academy of Sciences of the United States of America	Mason, Jacqueline M.Wei, Xin Fletcher, Graham C.Kiarash, Reza Brokx, Richard Hodgson, Richard Beletskaya, Irina Bray, Mark R.Mak, Tak W.	2017
	The discovery of orally bioavailable tyrosine threonine kinase (TTK) inhibitors: 3-(4-(heterocyclyl)phenyl)-1H-indazole-5-carboxamides as anticancer agents Journal:Journal of Medicinal Chemistry	Liu, Yong Lang, Yunhui Patel, Narendra Kumar Ng, Grace Laufer, Radoslaw Li, Sze Wan Edwards, Louise Forrest, Bryan Sampson, Peter B.Feher, Miklos Ban, Fuqiang Awrey, Donald E.Beletskaya, Irina Mao, Guodong Hodgson, Richard Plotnikova, Olga Qiu, Wei Chirgadze, Nickolay Y.Mason, Jacqueline M.Wei, Xin Lin, Dan Chi Chia Che, Yi Kiarash, Reza Madeira, Brian Fletcher, Graham C.Mak, Tak W.Bray, Mark R.Pauls, Henry W.	2015
	The discovery of PLK4 inhibitors: (E)-3-((1H-indazol-6-yl)methylene) indolin-2-ones as novel antiproliferative agents Journal:Journal of Medicinal Chemistry	Laufer, Radoslaw Forrest, Bryan Li, Sze Wan Liu, Yong Sampson, Peter Edwards, Louise Lang, Yunhui Awrey, Donald E.Mao, Guodong Plotnikova, Olga Leung, Genie Hodgson, Richard Beletskaya, Irina Mason, Jacqueline M.Luo, Xunyi Wei, Xin Yao, Yi Feher, Miklos Ban, Fuqiang Kiarash, Reza Green, Erin Mak, Tak W.Pan, Guohua Pauls, Henry W.	2013
	The discovery of polo-like kinase 4 inhibitors: Identification of (1 R,2 S)-2-(3-((E)-4-(((cis)-2,6-Dimethylmorpholino)methyl)styryl)-1 H -indazol-6-yl)-5′-methoxyspiro[cyclopropane-1,3′-indolin]-2′-one (CFI-400945) as a potent, orally active antitumor agent Journal:Journal of Medicinal Chemistry	Sampson, Peter B.Liu, Yong Forrest, Bryan Cumming, Graham Li, Sze Wan Patel, Narendra Kumar Edwards, Louise Laufer, Radoslaw Feher, Miklos Ban, Fuqiang Awrey, Donald E.Mao, Guodong Plotnikova, Olga Hodgson, Richard Beletskaya, Irina Mason, Jacqueline M.Luo, Xunyi Nadeem, Vincent Wei, Xin Kiarash, Reza Madeira, Brian Huang, Ping Mak, Tak W.Pan, Guohua Pauls, Henry W.	2015

Showing results 1 to 8 of 8