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obesity is hallmarked by endoplasmic reticulum (er) stress, chronic inflammation and metabolic dysfunctions. the control of obesity is the key to preventing the onset of non-alcoholic fatty liver disease, diabetes, cerebro-cardiovascular diseases and cancers. as a promising anti-obesity drug, plant-derived celastrol is challenged by poor water solubility and low oral bioavailability in clinical applications. the present study was designed to develop a biocompatible albumin-based nanoparticle carrier system for the controlled release of celastrol in diet-induced obese mice. celastrol was loaded into bovine serum albumin (bsa) nanoparticles to yield celastrol-bsa-nps by high pressure homogenization. celastrol-bsa-nps exhibited spherical morphology, narrow size distribution with a diameter of 125.6 ± 2.2 nm, satisfactory drug-loading efficiency at 13.88 ± 0.12% and a sustained-release profile over a period of 168 h. compared with free celastrol, celastrol-bsa-nps effectively improved cellular uptake, intestinal absorption and hepatic deposition. in animal experiments, celastrol-bsa-nps outperformed free celastrol in lowering lipid accumulation, improving insulin sensitivity, and reducing inflammation in diet-induced obesity. collectively, celastrol-bsa-nps exhibited better bioavailability and in vivo efficacy in the treatment of diet-induced obesity. importantly, such albumin-based nanoparticles may be a general biocompatible drug carrier system for the controlled release of hydrophobic compounds (e.g., celastrol) for the treatment of obesity and non-alcoholic fatty liver disease.

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the best for phd thesis in the faculties of arts, architecture, business & economics, education, law and social sciences (universityof hong kong), li ka shing prize, 2006-2007

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the best m.phil thesis in the faculties of dentistry, engineering, medicine and science (university of hong kong), li ka shing prize, 2001-2003.

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the best m.phil thesis in the faculties of dentistry, engineering, medicine and science (university of hong kong), li ka shing prize,1991-1993

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the best m.phil thesis in the faculties of dentistry, engineering, medicine and science (university of hong kong), li ka shing prize,1993-1995

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the best m.phil thesis in the faculties of dentistry, engineering, medicine and science (university of hong kong), li ka shing prize,1995-1997

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the best m.phil thesis in the faculties of dentistry, engineering, medicine and science (university of hong kong), li ka shing prize,1997-1999

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the best m.phil thesis in the faculties of dentistry, engineering, medicine and science (university of hong kong), li ka shing prize,2005-2006

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the best master's thesis award of the hong kong section, american society of civil engineers (2005-06)

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the best mphil thesis in the faculties of architecture, arts, business & economics, education, law and social sciences (university of hong kong), li ka shing prize, 2008-2009.

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the best mphil thesis in the faculties of architecture, arts, business & economics, education, law and social sciences (university of hong kong), li ka shing prize, 2010-11.

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the best mphil thesis in the faculties of architecture, arts, business & economics, education, law and social sciences (university of hong kong), li ka shing prize, 1993-1995.

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the best mphil thesis in the faculties of architecture, arts, business & economics, education, law and social sciences (university of hong kong), li ka shing prize, 1995-1997.

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the best mphil thesis in the faculties of architecture, arts, business & economics, education, law and social sciences (university of hong kong), li ka shing prize, 2001-2003.

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the best mphil thesis in the faculties of architecture, arts, business & economics, education, law and social sciences (university of hong kong), li ka shing prize, 2003-2005.

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the best mphil thesis in the faculties of architecture, arts, business& economics, education, law and social sciences (university of hongkong), li ka shing prize, 2009-2010

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the best mphil thesis in the faculties of architecture, arts, business& economics, education, law and social sciences (university of hongkong), li ka shing prize

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the best mphil thesis in the faculties of architecture, arts, business& economics, education, law and social sciences (university of hongkong), li ka shing prize, 1991-1993

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the best mphil thesis in the faculties of architecture, arts, business& economics, education, law and social sciences (university of hongkong), li ka shing prize, 1995-1997

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the best mphil thesis in the faculties of architecture, arts, business& economics, education, law and social sciences (university of hongkong), li ka shing prize, 1997-1999

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Showing results 49 to 68 of 100 < previous next >