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Conference Paper: Anticancer effect of gold (III) porphyrin in nasopharyngeal carcinoma

TitleAnticancer effect of gold (III) porphyrin in nasopharyngeal carcinoma
Authors
Issue Date2006
PublisherAmerican Association for Cancer Research
Citation
AACR 97th Annual Meeting, Washington, DC, 1–5 April 2006. In Cancer Research, 2006, v. 66 n. 8S, p. 1159-1160 Abstract no. 4937 How to Cite?
AbstractChinese population, especially in southern China, has the highest incidence of nasopharyngeal carcinoma (NPC) in the world. Current treatment modalities include radiotherapy and chemotherapy, in which cisplatin is commonly used. Cisplatin-resistance, however, occurs in about 30-40% of treated individuals. Newer drugs with more potent effectiveness are therefore in need. Gold(III) porphyrin has been shown to inhibit survival of various cancer cells in vitro (Che CM et al, 2003). Here we report that from MTT assay, gold(III) porphyrin effectively inhibited growth of NPC cell lines, cisplatin-sensitive SUNE1 cells and cisplatin-resistant CNE2 cells, with an IC50 0.12±0.02 μM and 0.14±0.01 μM respectively, both of which are 100 fold more potent compared with that of cisplatin (16.5±1.04μM for SUNE1 and 89.3±5.21 μM for CNE2). Annex-V/PI staining indicated that gold(III) porphyrin-indiced growth inhibition of NPC cell lines in vitro is due to induction of apoptosis. In tumour-implanted mice, we also showed that administration of 3 mg/kg/wk gold(III) porphyrin compound induces significant inhibition of tumour growth, compared to treatment with vehicle control or cisplatin. Of note, such a treatment was not associated with body weight loss or noticeable side effects. Immunohistology study confirmed that gold(III) porphyrin induced apoptosis of tumour cells through intrinsic pathway with an increase of caspase 9 expression. Gold(III) porphyrin, therefore, may become a potential chemotherapeutic agent for NPC.
Persistent Identifierhttp://hdl.handle.net/10722/97668
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372

 

DC FieldValueLanguage
dc.contributor.authorTo, YFen_HK
dc.contributor.authorSun, RWYen_HK
dc.contributor.authorTam, PKHen_HK
dc.contributor.authorChe, CMen_HK
dc.contributor.authorLin, CLen_HK
dc.date.accessioned2010-09-25T17:17:40Z-
dc.date.available2010-09-25T17:17:40Z-
dc.date.issued2006en_HK
dc.identifier.citationAACR 97th Annual Meeting, Washington, DC, 1–5 April 2006. In Cancer Research, 2006, v. 66 n. 8S, p. 1159-1160 Abstract no. 4937-
dc.identifier.issn0008-5472-
dc.identifier.urihttp://hdl.handle.net/10722/97668-
dc.description.abstractChinese population, especially in southern China, has the highest incidence of nasopharyngeal carcinoma (NPC) in the world. Current treatment modalities include radiotherapy and chemotherapy, in which cisplatin is commonly used. Cisplatin-resistance, however, occurs in about 30-40% of treated individuals. Newer drugs with more potent effectiveness are therefore in need. Gold(III) porphyrin has been shown to inhibit survival of various cancer cells in vitro (Che CM et al, 2003). Here we report that from MTT assay, gold(III) porphyrin effectively inhibited growth of NPC cell lines, cisplatin-sensitive SUNE1 cells and cisplatin-resistant CNE2 cells, with an IC50 0.12±0.02 μM and 0.14±0.01 μM respectively, both of which are 100 fold more potent compared with that of cisplatin (16.5±1.04μM for SUNE1 and 89.3±5.21 μM for CNE2). Annex-V/PI staining indicated that gold(III) porphyrin-indiced growth inhibition of NPC cell lines in vitro is due to induction of apoptosis. In tumour-implanted mice, we also showed that administration of 3 mg/kg/wk gold(III) porphyrin compound induces significant inhibition of tumour growth, compared to treatment with vehicle control or cisplatin. Of note, such a treatment was not associated with body weight loss or noticeable side effects. Immunohistology study confirmed that gold(III) porphyrin induced apoptosis of tumour cells through intrinsic pathway with an increase of caspase 9 expression. Gold(III) porphyrin, therefore, may become a potential chemotherapeutic agent for NPC.-
dc.languageengen_HK
dc.publisherAmerican Association for Cancer Research-
dc.relation.ispartofCancer Researchen_HK
dc.titleAnticancer effect of gold (III) porphyrin in nasopharyngeal carcinomaen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailSun, RWY: rwysun@hku.hken_HK
dc.identifier.emailTam, PKH: paultam@hkucc.hku.hken_HK
dc.identifier.emailChe, CM: cmche@hku.hken_HK
dc.identifier.emailLiu, CL: clliu@hkucc.hku.hken_HK
dc.identifier.authoritySun, RWY=rp00781en_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.identifier.hkuros116371en_HK

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