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Conference Paper: Genome-wide study of the anti-tumor effect of gold-1a, a novel chemo-cytotoxic agent forhepatocellular carcinoma (HCC)

TitleGenome-wide study of the anti-tumor effect of gold-1a, a novel chemo-cytotoxic agent forhepatocellular carcinoma (HCC)
Authors
Issue Date2006
PublisherWiley-Blackwell Publishing Asia
Citation
Shanghai—Hong Kong International Liver Congress, Shanghai, China, 25–28 March 2006. In Journal of Gastroenterology and Hepatology, 2006, v. 21 n. S2, p. A159 How to Cite?
AbstractHepatocellular Carcinoma (HCC) is often diagnosed at an advancedstage that it is no longer surgically resectable. Therefore, novel andeffective chemotherapy agents are urgently needed. We have recentlyshown that gold (III) meso-tetraarylporphyrin 1a (gold-1a) is a poten-tially promising chemotherapeutic drug to treat HCC (Lum et al., IntJ Cancer, in press). Here, we investigate the molecular mechanism ofthe anti-tumor effect of gold-1a by genome-wide cDNA microarrayand bioinformatic approaches. In rat hepatoma McA-RH7777 cells,Gold-1a treatment induced apoptosis through the expressions ofCaspase 3, 6, and 12. It up-regulated pathways in G1 phase cell cyclecontrol through Myc and SMAD 4,7 signaling, and promote DNArepair through Gadd34 and Gadd153 (members of the growth arrestand DNA-damage-inducible family). Furthermore, Gold-1a sup-pressed the expression of an angiogenesis gene Serpine1 and inhib-ited microvessel endothelial cell proliferation and microvessel tubeformation. Consistent with results from the genome wide in vitrostudies, we showed that Gold-1a treatment not only enhanced tumorapoptosis and necrosis, but also reduced microvessel density in tumortissues in an in vivo study in a rat orthotopic HCC model. Based onthe expression data and the known protein-protein interaction, weelucidated the global signal transduction pathways that lead to thepotent anti-tumor effect of Gold-1a.
Persistent Identifierhttp://hdl.handle.net/10722/97464
ISSN
2015 Impact Factor: 3.322
2015 SCImago Journal Rankings: 1.190

 

DC FieldValueLanguage
dc.contributor.authorLi, HYen_HK
dc.contributor.authorLum, CTen_HK
dc.contributor.authorKung, HFen_HK
dc.contributor.authorChe, CMen_HK
dc.contributor.authorLin, MCen_HK
dc.date.accessioned2010-09-25T17:09:58Z-
dc.date.available2010-09-25T17:09:58Z-
dc.date.issued2006en_HK
dc.identifier.citationShanghai—Hong Kong International Liver Congress, Shanghai, China, 25–28 March 2006. In Journal of Gastroenterology and Hepatology, 2006, v. 21 n. S2, p. A159en_HK
dc.identifier.issn0815-9319-
dc.identifier.urihttp://hdl.handle.net/10722/97464-
dc.description.abstractHepatocellular Carcinoma (HCC) is often diagnosed at an advancedstage that it is no longer surgically resectable. Therefore, novel andeffective chemotherapy agents are urgently needed. We have recentlyshown that gold (III) meso-tetraarylporphyrin 1a (gold-1a) is a poten-tially promising chemotherapeutic drug to treat HCC (Lum et al., IntJ Cancer, in press). Here, we investigate the molecular mechanism ofthe anti-tumor effect of gold-1a by genome-wide cDNA microarrayand bioinformatic approaches. In rat hepatoma McA-RH7777 cells,Gold-1a treatment induced apoptosis through the expressions ofCaspase 3, 6, and 12. It up-regulated pathways in G1 phase cell cyclecontrol through Myc and SMAD 4,7 signaling, and promote DNArepair through Gadd34 and Gadd153 (members of the growth arrestand DNA-damage-inducible family). Furthermore, Gold-1a sup-pressed the expression of an angiogenesis gene Serpine1 and inhib-ited microvessel endothelial cell proliferation and microvessel tubeformation. Consistent with results from the genome wide in vitrostudies, we showed that Gold-1a treatment not only enhanced tumorapoptosis and necrosis, but also reduced microvessel density in tumortissues in an in vivo study in a rat orthotopic HCC model. Based onthe expression data and the known protein-protein interaction, weelucidated the global signal transduction pathways that lead to thepotent anti-tumor effect of Gold-1a.-
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing Asia-
dc.relation.ispartofJournal of Gastroenterology and Hepatologyen_HK
dc.titleGenome-wide study of the anti-tumor effect of gold-1a, a novel chemo-cytotoxic agent forhepatocellular carcinoma (HCC)en_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLum, CT: ctlum@graduate.hku.hken_HK
dc.identifier.emailChe, CM: cmche@hku.hken_HK
dc.identifier.emailLin, MC: mcllin@HKUCC.hku.hken_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.identifier.authorityLin, MC=rp00746en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1440-1746.2006.04414.x-
dc.identifier.hkuros114894en_HK
dc.identifier.hkuros137054-
dc.identifier.volume21en_HK
dc.identifier.issueS2en_HK
dc.identifier.spage159en_HK

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