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Conference Paper: The vasorelaxation effect of osthole, derived from radix angelicae pubescentis, in porcine coronary artery

TitleThe vasorelaxation effect of osthole, derived from radix angelicae pubescentis, in porcine coronary artery
Authors
Issue Date2007
PublisherFederation of American Societies for Experimental Biology
Citation
Experimental Biology 2007, Washington, DC, 28 April–5 May 2007. In The FASEB Journal, 2007, v. 21 n. 6, p. A1165 How to Cite?
AbstractRadix Angelicae Pubescentis is a traditional Chinese medicine used to treat thrombosis. Osthole, a coumarin from Angelica pubescens, possesses antiarrhythmic activity. The vascular effects of Angelica pubescens extract (APE) and osthole, as well as their underlying signaling pathways, were investigated in isolated porcine coronary artery rings contracted with U46619. APE (20–80 μg/ml) dose-dependently relaxed endothelium-intact and endothelium-disrupted arterial rings to a similar extent. Osthole induced relaxation in endothelium-intact rings with a lower threshold concentration (< 10 μM) than in endothelium-disrupted rings (> 10 μM). In the presence of L-NAME (a nitric oxide synthase inhibitor) or ODQ (a soluble guanylyl cyclase inhibitor), relaxation to osthole in endothelium-intact rings was similar to that in endothelium-disrupted rings. Neither APE- nor osthole-induced relaxation was inhibited by SQ22536 (an adenylyl cyclase inhibitor). Our results demonstrated that APE acted directly on vascular smooth muscle to induce relaxation, whereas osthole acted on both endothelium and smooth muscle for relaxation. The endothelium-dependent relaxation of osthole was mediated through nitric oxide-cGMP signaling cascade. Mechanisms other than cAMP signaling pathway appeared to be responsible for endothelium-independent relaxation effect of APE and osthole.
Persistent Identifierhttp://hdl.handle.net/10722/97383
ISSN
2015 Impact Factor: 5.299
2015 SCImago Journal Rankings: 2.775

 

DC FieldValueLanguage
dc.contributor.authorChan, LYen_HK
dc.contributor.authorKeung, WYWen_HK
dc.contributor.authorYeung, KYen_HK
dc.contributor.authorLeung, SWSen_HK
dc.contributor.authorChe, CMen_HK
dc.contributor.authorMan, RYKen_HK
dc.date.accessioned2010-09-25T17:06:57Z-
dc.date.available2010-09-25T17:06:57Z-
dc.date.issued2007en_HK
dc.identifier.citationExperimental Biology 2007, Washington, DC, 28 April–5 May 2007. In The FASEB Journal, 2007, v. 21 n. 6, p. A1165-
dc.identifier.issn0892-6638-
dc.identifier.urihttp://hdl.handle.net/10722/97383-
dc.description.abstractRadix Angelicae Pubescentis is a traditional Chinese medicine used to treat thrombosis. Osthole, a coumarin from Angelica pubescens, possesses antiarrhythmic activity. The vascular effects of Angelica pubescens extract (APE) and osthole, as well as their underlying signaling pathways, were investigated in isolated porcine coronary artery rings contracted with U46619. APE (20–80 μg/ml) dose-dependently relaxed endothelium-intact and endothelium-disrupted arterial rings to a similar extent. Osthole induced relaxation in endothelium-intact rings with a lower threshold concentration (< 10 μM) than in endothelium-disrupted rings (> 10 μM). In the presence of L-NAME (a nitric oxide synthase inhibitor) or ODQ (a soluble guanylyl cyclase inhibitor), relaxation to osthole in endothelium-intact rings was similar to that in endothelium-disrupted rings. Neither APE- nor osthole-induced relaxation was inhibited by SQ22536 (an adenylyl cyclase inhibitor). Our results demonstrated that APE acted directly on vascular smooth muscle to induce relaxation, whereas osthole acted on both endothelium and smooth muscle for relaxation. The endothelium-dependent relaxation of osthole was mediated through nitric oxide-cGMP signaling cascade. Mechanisms other than cAMP signaling pathway appeared to be responsible for endothelium-independent relaxation effect of APE and osthole.-
dc.languageengen_HK
dc.publisherFederation of American Societies for Experimental Biology-
dc.relation.ispartofThe FASEB Journalen_HK
dc.titleThe vasorelaxation effect of osthole, derived from radix angelicae pubescentis, in porcine coronary arteryen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailYeung, KY: dkyyeung@hkucc.hku.hken_HK
dc.identifier.emailLeung, SWS: swsleung@HKUCC.hku.hken_HK
dc.identifier.emailChe, CM: cmche@hku.hken_HK
dc.identifier.emailMan, RYK: rykman@hkucc.hku.hken_HK
dc.identifier.authorityLeung, SWS=rp00235en_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.identifier.authorityMan, RYK=rp00236en_HK
dc.identifier.hkuros136369en_HK

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