File Download

There are no files associated with this item.

Supplementary

Conference Paper: Determination of solution structures of loloatins and tyrocidine-A by NMR spectroscopy

TitleDetermination of solution structures of loloatins and tyrocidine-A by NMR spectroscopy
Authors
Issue Date2005
Citation
Croucher Foundation Advanced Study Institute: Advances in Protein Sciences, Biochemistry Department, The Chinese University of Hong Kong, Hong Kong, 15-17 December 2005 , p. 46, abstract no. PO-30 How to Cite?
AbstractCultured marine microorganisms represent a promising new source of bioactive metabolites with potential for development into drugs for treating human disease. One area where new drugs are desperately needed is in the treatment of antibiotic-resistant strains of human bacterial pathogens. Loloatins A to D is a family of cyclic decapeptides originally isolated from laboratory cultures of a tropical marine bacterium collected from the Great Barrier Reef at the southern coast of Papua New Guinea. The loloatins exhibit potent antibiotic activity against several resistant gram-positive and gram-negative bacteria, including methicillin-resistant Staphyloccoccus aureus, vancomycin-resistant enterococci, and drug-resistant Streptococcus pneumoniae. Therefore they are promising templates for the development of new antibiotics. We have employed NMR spectroscopy combined with molecular simulation using CNS/ARIA to determine the solution structures of loloatins A, B, C as well as another well-know cyclic decapeptide, Tyrocidine-A.
Persistent Identifierhttp://hdl.handle.net/10722/97334

 

DC FieldValueLanguage
dc.contributor.authorYang, Yen_HK
dc.contributor.authorGuan, Xen_HK
dc.contributor.authorTse, MKen_HK
dc.contributor.authorSze, KHen_HK
dc.contributor.authorHaynes, RKen_HK
dc.date.accessioned2010-09-25T17:05:07Z-
dc.date.available2010-09-25T17:05:07Z-
dc.date.issued2005en_HK
dc.identifier.citationCroucher Foundation Advanced Study Institute: Advances in Protein Sciences, Biochemistry Department, The Chinese University of Hong Kong, Hong Kong, 15-17 December 2005 , p. 46, abstract no. PO-30en_HK
dc.identifier.urihttp://hdl.handle.net/10722/97334-
dc.description.abstractCultured marine microorganisms represent a promising new source of bioactive metabolites with potential for development into drugs for treating human disease. One area where new drugs are desperately needed is in the treatment of antibiotic-resistant strains of human bacterial pathogens. Loloatins A to D is a family of cyclic decapeptides originally isolated from laboratory cultures of a tropical marine bacterium collected from the Great Barrier Reef at the southern coast of Papua New Guinea. The loloatins exhibit potent antibiotic activity against several resistant gram-positive and gram-negative bacteria, including methicillin-resistant Staphyloccoccus aureus, vancomycin-resistant enterococci, and drug-resistant Streptococcus pneumoniae. Therefore they are promising templates for the development of new antibiotics. We have employed NMR spectroscopy combined with molecular simulation using CNS/ARIA to determine the solution structures of loloatins A, B, C as well as another well-know cyclic decapeptide, Tyrocidine-A.-
dc.languageengen_HK
dc.relation.ispartofCroucher Foundation Advanced Study Institute: Advances in Protein Sciences, Biochemistry Department, The Chinese University of Hong Kong, Hong Kong, 15-17 December 2005en_HK
dc.titleDetermination of solution structures of loloatins and tyrocidine-A by NMR spectroscopyen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailSze, KH: khsze@hku.hken_HK
dc.identifier.authoritySze, KH=rp00785en_HK
dc.identifier.hkuros122700en_HK
dc.identifier.spage46-
dc.identifier.epage46en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats