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Conference Paper: Knocking down interferon induced transmembrane protein 1 (IFITM1) inhibited cell proliferation and invasion in glioma cells

TitleKnocking down interferon induced transmembrane protein 1 (IFITM1) inhibited cell proliferation and invasion in glioma cells
Authors
Issue Date2010
PublisherFederation of American Societies for Experimental Biology. Meeting abstracts can be accessed via http://www.fasebj.org/search.dtl
Citation
Experimental Biology 2010, Anaheim, CA, 24-28 April 2010. In The FASEB Journal, 2010, v. 24 n. 1S, p. 674.2 How to Cite?
AbstractHere we investigated the role of Interferon Induced Transmembrane Protein 1 (IFITM1) in glioma carcinogenesis. We determined the expression levels of IFITM1 in different glioma cell lines, examined its role in cell proliferation/cell migration & invasion, and the corresponding molecular mechanism in glioma cells. Our results showed that IFITM1 mRNA level was elevated in four of five widely used glioma cell lines and positively correlated with their tumorigenic abilities. Suppression of IFITM1 by siIFITM1 inhibited the proliferation of U-373 MG and U-87 MG glioma cells lines in a time dependent manner. The growth inhibition effect of siIFITM1 was mediated not by apoptosis but G1 to S phase cell cycle arrest, which are mediated via decreased G1/S-specific cylin-D1, cyclin-dependent kinase 2 (CDK2) and increased cyclin-dependent kinase inhibitor 1B (p27kip1). Furthermore, IFITM1 knockdown significantly inhibit the migration and invasion of U-373 MG and U-87 MG cells, which was mediated by decreased MMP9 expression and activity. Taken together, these results suggested IFITM1 might be a potential candidate oncogene in glioma.
DescriptionPoster Session: Biochemistry and Molecular Biology: no. 674. Membrane Proteins as Drug Targets: B121 abstract no. 674.2
Persistent Identifierhttp://hdl.handle.net/10722/97237
ISSN
2015 Impact Factor: 5.299
2015 SCImago Journal Rankings: 2.775

 

DC FieldValueLanguage
dc.contributor.authorLin, MCen_HK
dc.contributor.authorYu, Fen_HK
dc.contributor.authorNg, SMen_HK
dc.contributor.authorKung, HFen_HK
dc.date.accessioned2010-09-25T17:01:32Z-
dc.date.available2010-09-25T17:01:32Z-
dc.date.issued2010en_HK
dc.identifier.citationExperimental Biology 2010, Anaheim, CA, 24-28 April 2010. In The FASEB Journal, 2010, v. 24 n. 1S, p. 674.2-
dc.identifier.issn0892-6638-
dc.identifier.urihttp://hdl.handle.net/10722/97237-
dc.descriptionPoster Session: Biochemistry and Molecular Biology: no. 674. Membrane Proteins as Drug Targets: B121 abstract no. 674.2-
dc.description.abstractHere we investigated the role of Interferon Induced Transmembrane Protein 1 (IFITM1) in glioma carcinogenesis. We determined the expression levels of IFITM1 in different glioma cell lines, examined its role in cell proliferation/cell migration & invasion, and the corresponding molecular mechanism in glioma cells. Our results showed that IFITM1 mRNA level was elevated in four of five widely used glioma cell lines and positively correlated with their tumorigenic abilities. Suppression of IFITM1 by siIFITM1 inhibited the proliferation of U-373 MG and U-87 MG glioma cells lines in a time dependent manner. The growth inhibition effect of siIFITM1 was mediated not by apoptosis but G1 to S phase cell cycle arrest, which are mediated via decreased G1/S-specific cylin-D1, cyclin-dependent kinase 2 (CDK2) and increased cyclin-dependent kinase inhibitor 1B (p27kip1). Furthermore, IFITM1 knockdown significantly inhibit the migration and invasion of U-373 MG and U-87 MG cells, which was mediated by decreased MMP9 expression and activity. Taken together, these results suggested IFITM1 might be a potential candidate oncogene in glioma.-
dc.languageengen_HK
dc.publisherFederation of American Societies for Experimental Biology. Meeting abstracts can be accessed via http://www.fasebj.org/search.dtl-
dc.relation.ispartofThe FASEB Journalen_HK
dc.titleKnocking down interferon induced transmembrane protein 1 (IFITM1) inhibited cell proliferation and invasion in glioma cellsen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLin, MC: mcllin@HKUCC.hku.hken_HK
dc.identifier.emailNg, SM: ssmng@hku.hken_HK
dc.identifier.authorityLin, MC=rp00746en_HK
dc.identifier.authorityNg, SM=rp00767en_HK
dc.identifier.hkuros169014en_HK
dc.publisher.placeUnited States-
dc.description.otherExperimental Biology 2010, Anaheim, California, USA, 24-28 April 2010, Poster Session: Biochemistry and Molecular Biology: no. 674. Membrane Proteins as Drug Targets: B121 abstract no. 674.2. In The FASEB Journal, 2010, v. 24 Meeting Abstract Suppl., abstract no. 674.2-

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