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Conference Paper: Gold(III) compounds as novel cytotoxic agents forhepatocellular carcinoma

TitleGold(III) compounds as novel cytotoxic agents forhepatocellular carcinoma
Authors
Issue Date2006
PublisherWiley-Blackwell Publishing Asia
Citation
Shanghai—Hong Kong International Liver Congress, Shanghai, China, 25–28 March 2006. In Journal of Gastroenterology and Hepatology, 2006, v. 21 n. S2, p. A93-A94 How to Cite?
AbstractToward development of new metal-based anti-tumor agents, gold(III)compounds have received considerable attention. Although somegold(III) compounds are known to exhibit interesting cytotoxicitytoward selected tumor cell lines, their further development is ham-pered by their poor stability under physiological conditions. Here we describe several gold(III) compound (1–3, Scheme 1) containingmacrocyclic N-donor ligands.[1,2,3]All of them are stable in physio-logical relevant conditions and are highly cytotoxic (IC50= 0.1–12 mM) against hepatocellular carcinoma cells; flow cytometric experiments showed that 1 is a potent apoptotic inducer.
Persistent Identifierhttp://hdl.handle.net/10722/96836
ISSN
2015 Impact Factor: 3.322
2015 SCImago Journal Rankings: 1.190

 

DC FieldValueLanguage
dc.contributor.authorSun, RWYen_HK
dc.contributor.authorLum, CTen_HK
dc.contributor.authorLin, MCen_HK
dc.contributor.authorKung, HFen_HK
dc.contributor.authorChe, CMen_HK
dc.date.accessioned2010-09-25T16:46:47Z-
dc.date.available2010-09-25T16:46:47Z-
dc.date.issued2006en_HK
dc.identifier.citationShanghai—Hong Kong International Liver Congress, Shanghai, China, 25–28 March 2006. In Journal of Gastroenterology and Hepatology, 2006, v. 21 n. S2, p. A93-A94en_HK
dc.identifier.issn0815-9319-
dc.identifier.urihttp://hdl.handle.net/10722/96836-
dc.description.abstractToward development of new metal-based anti-tumor agents, gold(III)compounds have received considerable attention. Although somegold(III) compounds are known to exhibit interesting cytotoxicitytoward selected tumor cell lines, their further development is ham-pered by their poor stability under physiological conditions. Here we describe several gold(III) compound (1–3, Scheme 1) containingmacrocyclic N-donor ligands.[1,2,3]All of them are stable in physio-logical relevant conditions and are highly cytotoxic (IC50= 0.1–12 mM) against hepatocellular carcinoma cells; flow cytometric experiments showed that 1 is a potent apoptotic inducer.-
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing Asia-
dc.relation.ispartofJournal of Gastroenterology and Hepatologyen_HK
dc.titleGold(III) compounds as novel cytotoxic agents forhepatocellular carcinomaen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailSun, RWY: rwysun@hku.hken_HK
dc.identifier.emailLum, CT: ctlum@graduate.hku.hken_HK
dc.identifier.emailLin, MC: mcllin@HKUCC.hku.hken_HK
dc.identifier.emailChe, CM: cmche@hku.hken_HK
dc.identifier.authoritySun, RWY=rp00781en_HK
dc.identifier.authorityLin, MC=rp00746en_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1440-1746.2006.04406.x-
dc.identifier.hkuros117878en_HK
dc.identifier.hkuros137053-
dc.identifier.volume21en_HK
dc.identifier.issueS2en_HK
dc.identifier.spage93en_HK
dc.identifier.epage94en_HK

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