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Conference Paper: Developing vestibular neurons display altered commissural projections with depletion of chondroitin sulfates of the hindbrain matrix

TitleDeveloping vestibular neurons display altered commissural projections with depletion of chondroitin sulfates of the hindbrain matrix
Authors
Issue Date2005
PublisherJapan Neuroscience Society
Citation
The 28th Annual Meeting of the Japan Neuroscience Society, Yokohama, Japan, 26-28 July 2005. In Neuroscience Research, 2005, v. 52 n. S1, p. S179 Abstract no. P3–037 How to Cite?
AbstractChondroitin sulfate (CS) proteoglycans are involved in matrix interactions that restrict neuronal populations and their processes. To assess vestibular commissural projections in environments depleted of CS moieties, chondroitinase ABC was delivered into the 4th ventricles of rat embryos (E11.5–E13.5) in culture and DiI tracing was performed from the vestibular nuclear complex near the VIIIth cranial nerve entry zone. Enzyme treatment in E11.5 resulted in robust outgrowths that extended more than half-way towards the midline. Enzyme treatments in E12.5 and E13.5 resulted in defasciculation and divergence of outgrowths from the course of the pioneers. These results provide in vivo evidence for contributions of CS to limit stray outgrowth and foster axonal fasciculation as vestibular neurons project across the midline towards the contralateral target.
Persistent Identifierhttp://hdl.handle.net/10722/96749
ISSN
2015 Impact Factor: 2.004
2015 SCImago Journal Rankings: 0.985

 

DC FieldValueLanguage
dc.contributor.authorLau, JWKen_HK
dc.contributor.authorKwok, JCFen_HK
dc.contributor.authorNg, KYen_HK
dc.contributor.authorChan, YSen_HK
dc.contributor.authorShum, DKYen_HK
dc.date.accessioned2010-09-25T16:43:29Z-
dc.date.available2010-09-25T16:43:29Z-
dc.date.issued2005en_HK
dc.identifier.citationThe 28th Annual Meeting of the Japan Neuroscience Society, Yokohama, Japan, 26-28 July 2005. In Neuroscience Research, 2005, v. 52 n. S1, p. S179 Abstract no. P3–037en_HK
dc.identifier.issn0168-0102-
dc.identifier.urihttp://hdl.handle.net/10722/96749-
dc.description.abstractChondroitin sulfate (CS) proteoglycans are involved in matrix interactions that restrict neuronal populations and their processes. To assess vestibular commissural projections in environments depleted of CS moieties, chondroitinase ABC was delivered into the 4th ventricles of rat embryos (E11.5–E13.5) in culture and DiI tracing was performed from the vestibular nuclear complex near the VIIIth cranial nerve entry zone. Enzyme treatment in E11.5 resulted in robust outgrowths that extended more than half-way towards the midline. Enzyme treatments in E12.5 and E13.5 resulted in defasciculation and divergence of outgrowths from the course of the pioneers. These results provide in vivo evidence for contributions of CS to limit stray outgrowth and foster axonal fasciculation as vestibular neurons project across the midline towards the contralateral target.-
dc.languageengen_HK
dc.publisherJapan Neuroscience Society-
dc.relation.ispartofNeuroscience Researchen_HK
dc.titleDeveloping vestibular neurons display altered commissural projections with depletion of chondroitin sulfates of the hindbrain matrixen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLau, JWK: jaegerlau@yahoo.com.hken_HK
dc.identifier.emailKwok, JCF: h9600218@hkusua.hku.hken_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.emailShum, DKY: shumdkhk@hkucc.hku.hken_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.identifier.authorityShum, DKY=rp00321en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.neures.2005.04.001-
dc.identifier.hkuros121762en_HK
dc.identifier.spageS179en_HK

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