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Conference Paper: The autocrine sPDZD2 protein is a potential p53 activator

TitleThe autocrine sPDZD2 protein is a potential p53 activator
Authors
Issue Date2007
PublisherAmerican Association for Cancer Research
Citation
The 2007 AACR Centennial Conference, Singapore, 4-8 November 2007. In Clinical Cancer Research, 2007, v. 13 n. 22S, p. B40 How to Cite?
AbstractPDZ domain containing protein 2 (PDZD2) is a ubiquitously expressed six-PDZ domain protein of largely undefined functions. It is cleaved by caspase-3 to form a secreted PDZ domain containing protein 2 (sPDZD2). The sPDZD2 protein has been proposed to function as a potential autocrine prostate tumor suppressor. In this study, we investigated the effects of sPDZD2 on the growth of human prostate, breast and liver cancer cells. The sPDZD2 protein was found to induce senescence of prostate cancer DU145 cells, quiescence of breast cancer MCF-7 and liver cancer Hep-G2 cells, via transcriptional activation of mutant or wild-type p53. Our results indicate that sPDZD2 is worthy of further development as a novel p53 activator for cancer therapy.
DescriptionConference Theme: Translational Cancer Medicine
Persistent Identifierhttp://hdl.handle.net/10722/96639
ISSN
2015 Impact Factor: 8.738
2015 SCImago Journal Rankings: 5.314

 

DC FieldValueLanguage
dc.contributor.authorTam, CWen_HK
dc.contributor.authorLiu, VWSen_HK
dc.contributor.authorLeung, WYen_HK
dc.contributor.authorYao, KMen_HK
dc.contributor.authorShiu, SYWen_HK
dc.date.accessioned2010-09-25T16:40:06Z-
dc.date.available2010-09-25T16:40:06Z-
dc.date.issued2007en_HK
dc.identifier.citationThe 2007 AACR Centennial Conference, Singapore, 4-8 November 2007. In Clinical Cancer Research, 2007, v. 13 n. 22S, p. B40en_HK
dc.identifier.issn1078-0432-
dc.identifier.urihttp://hdl.handle.net/10722/96639-
dc.descriptionConference Theme: Translational Cancer Medicine-
dc.description.abstractPDZ domain containing protein 2 (PDZD2) is a ubiquitously expressed six-PDZ domain protein of largely undefined functions. It is cleaved by caspase-3 to form a secreted PDZ domain containing protein 2 (sPDZD2). The sPDZD2 protein has been proposed to function as a potential autocrine prostate tumor suppressor. In this study, we investigated the effects of sPDZD2 on the growth of human prostate, breast and liver cancer cells. The sPDZD2 protein was found to induce senescence of prostate cancer DU145 cells, quiescence of breast cancer MCF-7 and liver cancer Hep-G2 cells, via transcriptional activation of mutant or wild-type p53. Our results indicate that sPDZD2 is worthy of further development as a novel p53 activator for cancer therapy.-
dc.languageengen_HK
dc.publisherAmerican Association for Cancer Research-
dc.relation.ispartofClinical Cancer Researchen_HK
dc.titleThe autocrine sPDZD2 protein is a potential p53 activatoren_HK
dc.typeConference_Paperen_HK
dc.identifier.emailTam, CW: h9810424@graduate.hku.hken_HK
dc.identifier.emailLiu, VWS: vwsliu@hkusua.hku.hken_HK
dc.identifier.emailYao, KM: kmyao@hkusua.hku.hken_HK
dc.identifier.emailShiu, SYW: sywshiu@hkucc.hku.hken_HK
dc.identifier.authorityLiu, VWS=rp00341en_HK
dc.identifier.authorityYao, KM=rp00344en_HK
dc.identifier.authorityShiu, SYW=rp00384en_HK
dc.identifier.hkuros139211en_HK
dc.identifier.spageB40en_HK
dc.identifier.epageB40-

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