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Conference Paper: Change in perineuronal net of rat vestibular nuclear neurons in development and in injury

TitleChange in perineuronal net of rat vestibular nuclear neurons in development and in injury
Authors
Issue Date2006
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/NSG
Citation
The 25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 5-6 December 2005. In Neurosignals, 2006, v. 15 n. 3, p. 147-148 How to Cite?
AbstractPerineuronal net (PN) is a lattice-like extracellular matrix surrounding neurons. With the use of the lectin Wisteria floribunda agglutinin as a cytochemical marker, we studied the expression patterns of PN within the vestibular nuclei in normal postnatal rats (P1 to adult) as well as in adult rats at 5 to 11 days after unilateral labyrinthectomy (UL). In uninjured rats, PN was detectable by P3 in the vestibular nucleus as fuzziness about neuronal cell bodies. From P9 onwards, the fuzzy PN was progressively consolidated into a network organization. The fuzziness was no longer observable after P12. During postnatal development, the number of cell bodies indicating PN was found to increase, reaching adult level by P21. In unilateral labyrinthectometomized rats, the PN on the labyrinth-intact side remained similar to uninjured age-matched rats. On the lesioned side at 5 days after UL, the PN recapitulated the fuzziness of early postnatal stages of uninjured rats. By 11 days after UL, the PN resumed the network pattern. Taken together, our findings suggest that the PN plays a crucial role in modulating the pericellular environment of vestibular nuclear neurons both during postnatal development of normal rats as well as in adult rats following destruction of the ipsilateral inner ear.
Persistent Identifierhttp://hdl.handle.net/10722/96435
ISSN
2015 Impact Factor: 1.593
2015 SCImago Journal Rankings: 0.763

 

DC FieldValueLanguage
dc.contributor.authorMa, CWen_HK
dc.contributor.authorLai, SKen_HK
dc.contributor.authorShum, DKYen_HK
dc.contributor.authorChan, YSen_HK
dc.date.accessioned2010-09-25T16:33:43Z-
dc.date.available2010-09-25T16:33:43Z-
dc.date.issued2006en_HK
dc.identifier.citationThe 25th Annual Scientific Meeting of the Hong Kong Society of Neurosciences, Hong Kong, 5-6 December 2005. In Neurosignals, 2006, v. 15 n. 3, p. 147-148en_HK
dc.identifier.issn1424-862Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/96435-
dc.description.abstractPerineuronal net (PN) is a lattice-like extracellular matrix surrounding neurons. With the use of the lectin Wisteria floribunda agglutinin as a cytochemical marker, we studied the expression patterns of PN within the vestibular nuclei in normal postnatal rats (P1 to adult) as well as in adult rats at 5 to 11 days after unilateral labyrinthectomy (UL). In uninjured rats, PN was detectable by P3 in the vestibular nucleus as fuzziness about neuronal cell bodies. From P9 onwards, the fuzzy PN was progressively consolidated into a network organization. The fuzziness was no longer observable after P12. During postnatal development, the number of cell bodies indicating PN was found to increase, reaching adult level by P21. In unilateral labyrinthectometomized rats, the PN on the labyrinth-intact side remained similar to uninjured age-matched rats. On the lesioned side at 5 days after UL, the PN recapitulated the fuzziness of early postnatal stages of uninjured rats. By 11 days after UL, the PN resumed the network pattern. Taken together, our findings suggest that the PN plays a crucial role in modulating the pericellular environment of vestibular nuclear neurons both during postnatal development of normal rats as well as in adult rats following destruction of the ipsilateral inner ear.-
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/NSGen_HK
dc.relation.ispartofNeurosignalsen_HK
dc.rightsNeurosignals. Copyright © S Karger AG.en_HK
dc.titleChange in perineuronal net of rat vestibular nuclear neurons in development and in injuryen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1424-862X&volume=15&spage=147&epage=148&date=2006&atitle=Change+in+perineuronal+net+of+rat+vestibular+nuclear+neurons+in+development+and+in+injuryen_HK
dc.identifier.emailMa, CW: h0494175@hkusua.hku.hken_HK
dc.identifier.emailLai, SK: estherlai@hkusua.hku.hken_HK
dc.identifier.emailShum, DKY: shumdkhk@hkucc.hku.hken_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityShum, DKY=rp00321en_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000095356-
dc.identifier.hkuros129734en_HK
dc.identifier.volume15en_HK
dc.identifier.spage147en_HK
dc.identifier.epage148en_HK

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