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Conference Paper: Asymptomatic members with SOD1 mutation in a large kindred with familial amyotrophic lateral sclerosis have abnormal water diffusion characterisitcs

TitleAsymptomatic members with SOD1 mutation in a large kindred with familial amyotrophic lateral sclerosis have abnormal water diffusion characterisitcs
Authors
Issue Date2006
PublisherThe International Society for Magnetic Resonance in Medicine (ISMRM)
Citation
The 14th Scientific Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006), Seattle, WA., 6-12 May 2006, p. 726 How to Cite?
AbstractDTI was carried out in FALS/SALS patients and familial members with SOD1 mutation (AFALS) who may be in a pre-symptomatic phase of ALS. The changes in FA and TT were investigated in CBT/CST and in whole brain. In FALS/SALS, diffusion pattern changes were found in cerebral peduncle, internal capsule, sub-cortical white matter, cerebellum and frontal lobe while in AFALS, abnormal pattern could also be detected in the cerebral peduncle, cerebellum and frontal lobe but with a smaller extent. Our study indicates that DTI can show early diffusion changes in members with SOD1 mutation in FALS prior to symptom-onset.
Persistent Identifierhttp://hdl.handle.net/10722/96302

 

DC FieldValueLanguage
dc.contributor.authorNg, MCen_HK
dc.contributor.authorHo, JTen_HK
dc.contributor.authorHo, SLen_HK
dc.contributor.authorLee, Ren_HK
dc.contributor.authorLi, Gen_HK
dc.contributor.authorSong, Yen_HK
dc.contributor.authorChan, KHen_HK
dc.contributor.authorCheng, TSen_HK
dc.contributor.authorYang, ESen_HK
dc.contributor.authorLeong, LYen_HK
dc.date.accessioned2010-09-25T16:29:38Z-
dc.date.available2010-09-25T16:29:38Z-
dc.date.issued2006en_HK
dc.identifier.citationThe 14th Scientific Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2006), Seattle, WA., 6-12 May 2006, p. 726-
dc.identifier.urihttp://hdl.handle.net/10722/96302-
dc.description.abstractDTI was carried out in FALS/SALS patients and familial members with SOD1 mutation (AFALS) who may be in a pre-symptomatic phase of ALS. The changes in FA and TT were investigated in CBT/CST and in whole brain. In FALS/SALS, diffusion pattern changes were found in cerebral peduncle, internal capsule, sub-cortical white matter, cerebellum and frontal lobe while in AFALS, abnormal pattern could also be detected in the cerebral peduncle, cerebellum and frontal lobe but with a smaller extent. Our study indicates that DTI can show early diffusion changes in members with SOD1 mutation in FALS prior to symptom-onset.-
dc.languageengen_HK
dc.publisherThe International Society for Magnetic Resonance in Medicine (ISMRM)-
dc.relation.ispartofISMRM 2006 Scientific Meeting & Exhibitionen_HK
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleAsymptomatic members with SOD1 mutation in a large kindred with familial amyotrophic lateral sclerosis have abnormal water diffusion characterisitcsen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailHo, SL: slho@hku.hken_HK
dc.identifier.emailSong, Y: songy@hkucc.hku.hken_HK
dc.identifier.authoritySong, Y=rp00488en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.hkuros120391en_HK

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