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Conference Paper: Modifications in perineuronal nets of rat vestibular nuclear neurons during postnatal development and in injury

TitleModifications in perineuronal nets of rat vestibular nuclear neurons during postnatal development and in injury
Authors
Issue Date2007
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neures
Citation
The 30th Annual Meeting of the Japan Neuroscience Society, Yokohama, Japan, 10–12 September 2007. In Neuroscience Research, 2007, v. 58 n. S1, p. S98 How to Cite?
AbstractPerineuronal net (PN), the extracellular matrix around neurons, has been shown to be involved in neural plasticity. To determine if PN in the vestibular nuclei (VN) plays any role on plastic change of central vestibular network, we studied PN in two states of functional modifications in the vestibular system which are postnatal development of VN and compensation of VN neuronal activity after unilateral labyrinthectomy (UL). Staining with lectin WFA was used to identify PN around VN neurons. In postnatal VN, fuzzy PN was detectable by P3. They became consolidated from P9 onwards. The number of VN neurons with PN also increased with age, reaching adult level by P21. With UL, the PN on the lesioned side of adult rats became fuzzy at 3–5 days post-lesion but resumed normal by 11–14 days after UL. PN on the labyrinth-intact side, however, showed the compact network. Our findings suggest that structural changes of PN around VN neurons contribute to plasticity of central vestibular system.
Persistent Identifierhttp://hdl.handle.net/10722/96255
ISSN
2015 Impact Factor: 2.004
2015 SCImago Journal Rankings: 0.985

 

DC FieldValueLanguage
dc.contributor.authorMa, CWen_HK
dc.contributor.authorLai, CHen_HK
dc.contributor.authorShum, DKYen_HK
dc.contributor.authorChan, YSen_HK
dc.date.accessioned2010-09-25T16:28:10Z-
dc.date.available2010-09-25T16:28:10Z-
dc.date.issued2007en_HK
dc.identifier.citationThe 30th Annual Meeting of the Japan Neuroscience Society, Yokohama, Japan, 10–12 September 2007. In Neuroscience Research, 2007, v. 58 n. S1, p. S98en_HK
dc.identifier.issn0168-0102-
dc.identifier.urihttp://hdl.handle.net/10722/96255-
dc.description.abstractPerineuronal net (PN), the extracellular matrix around neurons, has been shown to be involved in neural plasticity. To determine if PN in the vestibular nuclei (VN) plays any role on plastic change of central vestibular network, we studied PN in two states of functional modifications in the vestibular system which are postnatal development of VN and compensation of VN neuronal activity after unilateral labyrinthectomy (UL). Staining with lectin WFA was used to identify PN around VN neurons. In postnatal VN, fuzzy PN was detectable by P3. They became consolidated from P9 onwards. The number of VN neurons with PN also increased with age, reaching adult level by P21. With UL, the PN on the lesioned side of adult rats became fuzzy at 3–5 days post-lesion but resumed normal by 11–14 days after UL. PN on the labyrinth-intact side, however, showed the compact network. Our findings suggest that structural changes of PN around VN neurons contribute to plasticity of central vestibular system.-
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neures-
dc.relation.ispartofNeuroscience Researchen_HK
dc.titleModifications in perineuronal nets of rat vestibular nuclear neurons during postnatal development and in injuryen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLai, CH: chlaib@HKUSUA.hku.hken_HK
dc.identifier.emailShum, DKY: shumdkhk@hkucc.hku.hken_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityLai, CH=rp00396en_HK
dc.identifier.authorityShum, DKY=rp00321en_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.neures.2007.06.1141-
dc.identifier.hkuros149736en_HK
dc.identifier.volume58en_HK
dc.identifier.spage98en_HK

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