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Conference Paper: Maturation profile of ionotropic glutamate receptors in central vestibular neurons of rats

TitleMaturation profile of ionotropic glutamate receptors in central vestibular neurons of rats
Authors
Issue Date2008
PublisherLippincott Williams & Wilkins
Citation
The 8th Biennial Meeting of Asia-Pacific Society for Neurochemistry, Shanghai, China, 24-26 June 2008. In Journal of Neurochemistry, 2008, v. 106 n. Suppl 1, p. 43-44 How to Cite?
AbstractTo investigate the role of ionotropic glutamate receptors (AMPAR and NMDAR) in the development of central vestibular neurons, whole-cell patch-clamp experiments were performed in spinal vestibular neurons of postnatal (P1 16) Sprague Dawley rats. The profiles of AMPAR- and NMDARmediated EPSCs evoked by electrical stimulation of the ipsilateral vestibular nerve were also studied. From P1 to P3, glutamatergic transmission is primarily mediated by NMDARs. The relative contribution of AMPARs versus NMDARs at vestibular afferent synapses increased during the first two weeks of life. Using minimal stimulation paradigm, we found that silent NMDAR-only synapses were present only up to P5. From P5 to P7, there was a significant increase in the quantal amplitude of AMPAR-mediated eEPSCs, as confirmed with the use of extracellular strontium instead of calcium, thereby increasing the AMPAR/NMDAR ratio. These age-dependent increase of AMPARs towards the end of the first postnatal week coincides with the disappearance of NMDAR-only synapses. Taken together, our findings provide evidence on the developmental shift in AMPAR and NMDAR of glutamatergic synapses, contributing to functional maturation of central vestibular neurons in postnatal rats. Acknowledgment: Supported by HKRGC.
Persistent Identifierhttp://hdl.handle.net/10722/96096
ISSN
2015 Impact Factor: 3.842
2015 SCImago Journal Rankings: 2.021

 

DC FieldValueLanguage
dc.contributor.authorLai, SKen_HK
dc.contributor.authorWong, TPen_HK
dc.contributor.authorYung, WHen_HK
dc.contributor.authorShum, DKYen_HK
dc.contributor.authorChan, YSen_HK
dc.date.accessioned2010-09-25T16:23:15Z-
dc.date.available2010-09-25T16:23:15Z-
dc.date.issued2008en_HK
dc.identifier.citationThe 8th Biennial Meeting of Asia-Pacific Society for Neurochemistry, Shanghai, China, 24-26 June 2008. In Journal of Neurochemistry, 2008, v. 106 n. Suppl 1, p. 43-44-
dc.identifier.issn0022-3042-
dc.identifier.urihttp://hdl.handle.net/10722/96096-
dc.description.abstractTo investigate the role of ionotropic glutamate receptors (AMPAR and NMDAR) in the development of central vestibular neurons, whole-cell patch-clamp experiments were performed in spinal vestibular neurons of postnatal (P1 16) Sprague Dawley rats. The profiles of AMPAR- and NMDARmediated EPSCs evoked by electrical stimulation of the ipsilateral vestibular nerve were also studied. From P1 to P3, glutamatergic transmission is primarily mediated by NMDARs. The relative contribution of AMPARs versus NMDARs at vestibular afferent synapses increased during the first two weeks of life. Using minimal stimulation paradigm, we found that silent NMDAR-only synapses were present only up to P5. From P5 to P7, there was a significant increase in the quantal amplitude of AMPAR-mediated eEPSCs, as confirmed with the use of extracellular strontium instead of calcium, thereby increasing the AMPAR/NMDAR ratio. These age-dependent increase of AMPARs towards the end of the first postnatal week coincides with the disappearance of NMDAR-only synapses. Taken together, our findings provide evidence on the developmental shift in AMPAR and NMDAR of glutamatergic synapses, contributing to functional maturation of central vestibular neurons in postnatal rats. Acknowledgment: Supported by HKRGC.-
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins-
dc.relation.ispartofJournal of Neurochemistryen_HK
dc.titleMaturation profile of ionotropic glutamate receptors in central vestibular neurons of ratsen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLai, SK: estherlai@hkusua.hku.hken_HK
dc.identifier.emailShum, DKY: shumdkhk@hkucc.hku.hken_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityShum, DKY=rp00321en_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1471-4159.2008.05436.x-
dc.identifier.hkuros149865en_HK

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