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Conference Paper: Studying the role of epidermal growth factor in chondrogenesis

TitleStudying the role of epidermal growth factor in chondrogenesis
Authors
Issue Date2001
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/DGD
Citation
The 14th International Congress of Developmental Biology (ISDB 2001), Kyoto, Japan, 8-12 July 2001. In Development, Growth and Differentiation, 2001, v. 43 n. suppl., p. S148, abstract no. W5-P22 How to Cite?
AbstractIn the growth plate, chondrocytes go through stages of rest, proliferation and hypertrophy. The hypertrophic chondrocytes are important in synthesis of the extracellular matrix. Our previous study has shown that epidermal growth factor (EGF) is expressed mainly in hypertrophic chondrocytes. Widespread overexpression of EGF in transgenic mice resulted in stunted growth and abnormalities in the growth plate. We therefore hypothesize that EGF may play a role in chondrogenesis. In order to test this, we are generating transgenic mice which overexpress EGF specifically in the proliferative zone of the growth plate. We will employ gene targeting to “knock-in” EGF into the Col9a1 locus which encodes collagen IX. Collagen IX is expressed in the proliferating chondrocytes and heterozygous null mutants are phenotypically normal. The phenotypic consequences of overexpression of EGF in proliferating chondrocytes wil be studied using morphometry and molecular markers.
DescriptionThis free journal suppl. entitled: Abstracts of the papers presented at the 14th International Congress of Developmental Biology, Kyoto, 8-12 July 2001.
Persistent Identifierhttp://hdl.handle.net/10722/96004
ISSN
2015 Impact Factor: 2.412
2015 SCImago Journal Rankings: 1.561

 

DC FieldValueLanguage
dc.contributor.authorNg, PKM-
dc.contributor.authorCheah, KSE-
dc.contributor.authorChan, AKW-
dc.contributor.authorWong, RWC-
dc.contributor.authorChan, SY-
dc.date.accessioned2010-09-25T16:20:21Z-
dc.date.available2010-09-25T16:20:21Z-
dc.date.issued2001-
dc.identifier.citationThe 14th International Congress of Developmental Biology (ISDB 2001), Kyoto, Japan, 8-12 July 2001. In Development, Growth and Differentiation, 2001, v. 43 n. suppl., p. S148, abstract no. W5-P22-
dc.identifier.issn0012-1592-
dc.identifier.urihttp://hdl.handle.net/10722/96004-
dc.descriptionThis free journal suppl. entitled: Abstracts of the papers presented at the 14th International Congress of Developmental Biology, Kyoto, 8-12 July 2001.-
dc.description.abstractIn the growth plate, chondrocytes go through stages of rest, proliferation and hypertrophy. The hypertrophic chondrocytes are important in synthesis of the extracellular matrix. Our previous study has shown that epidermal growth factor (EGF) is expressed mainly in hypertrophic chondrocytes. Widespread overexpression of EGF in transgenic mice resulted in stunted growth and abnormalities in the growth plate. We therefore hypothesize that EGF may play a role in chondrogenesis. In order to test this, we are generating transgenic mice which overexpress EGF specifically in the proliferative zone of the growth plate. We will employ gene targeting to “knock-in” EGF into the Col9a1 locus which encodes collagen IX. Collagen IX is expressed in the proliferating chondrocytes and heterozygous null mutants are phenotypically normal. The phenotypic consequences of overexpression of EGF in proliferating chondrocytes wil be studied using morphometry and molecular markers.-
dc.languageeng-
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/DGD-
dc.relation.ispartofDevelopment, Growth and Differentiation-
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.titleStudying the role of epidermal growth factor in chondrogenesis-
dc.typeConference_Paper-
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0012-1592&volume=43&issue=suppl&spage=S148&epage=&date=2001&atitle=Studying+the+role+of+epidermal+growth+factor+in+chondrogenesisen_HK
dc.identifier.emailNg, PKM: phoeben@hkucc.hku.hk-
dc.identifier.emailCheah, KSE: hrmbdkc@hku.hk-
dc.identifier.emailChan, AKW: ankwchan@hkucc.hku.hk-
dc.identifier.emailChan, SY: sychan@hkucc.hku.hk-
dc.identifier.authorityCheah, KSE=rp00342-
dc.identifier.authorityChan, SY=rp00356-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1046/j.1440-169X.2001.00005-Supplement.x-
dc.identifier.hkuros65036-
dc.identifier.volume43-
dc.identifier.issuesuppl.-
dc.identifier.spageS148, abstract no. W5-P22-
dc.identifier.epageS148, abstract no. W5-P22-
dc.publisher.placeAustralia-

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