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Conference Paper: Secretin is widely expressed during mouse embryonic development

TitleSecretin is widely expressed during mouse embryonic development
Authors
Issue Date2005
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/regpep
Citation
The 7th International Symposium on VIP, PACAP and Related Peptides. Rouen, France, 11-14 September 2005. In Regulatory Peptides, 2005, v. 130 n. 3, p. 176 How to Cite?
AbstractThe brain-gut peptide secretin has drawn increasing attentions due to its neuroactivities in the brain. In previous prenatal studies, secretin expression was reported after day 17 of gestation in the rat duodenum. Other than this, information on its expression pattern in developing organs and prenatal roles remains unclear. By in situ hybridization and immunohistochemical staining of E10.5, E12.5, E14.5 and E16.5 mouse embryos, secretin transcript and peptide are widely detected during development. They are expressed in several developing brain regions such as cephalic mesenchyme, cerebellar primordium and choroid plexus. Our findings on secretin expression in the cerebellar primordium are consistent with previous reports that both secretin transcript and peptide were detected in the cerebellum in adult rodents. In the developing intestine, however, secretin expression is different from previous report that the peptide is formed in the inner circular muscle rather than in the epithelial villi lining. Other than these organs, secretin is also detected in the developing heart including the ventricular epicardium and myocardium and certain structures of the developing kidney like ureteric bud, collecting duct and glomerulus. Localizations of secretin in distinct cell-types within the developing heart and kidney have provided novel information which RT – PCR and Northern blot analyses were unable to demonstrate in the past. In summary, the wide distribution of secretin in developing embryos strongly suggests for its functional role of in embryonic development.
Persistent Identifierhttp://hdl.handle.net/10722/95994
ISSN
2015 Impact Factor: 1.813
2015 SCImago Journal Rankings: 0.915

 

DC FieldValueLanguage
dc.contributor.authorSiu, KYen_HK
dc.contributor.authorSham, MHen_HK
dc.contributor.authorChow, BKCen_HK
dc.date.accessioned2010-09-25T16:20:02Z-
dc.date.available2010-09-25T16:20:02Z-
dc.date.issued2005en_HK
dc.identifier.citationThe 7th International Symposium on VIP, PACAP and Related Peptides. Rouen, France, 11-14 September 2005. In Regulatory Peptides, 2005, v. 130 n. 3, p. 176en_HK
dc.identifier.issn0167-0115en_HK
dc.identifier.urihttp://hdl.handle.net/10722/95994-
dc.description.abstractThe brain-gut peptide secretin has drawn increasing attentions due to its neuroactivities in the brain. In previous prenatal studies, secretin expression was reported after day 17 of gestation in the rat duodenum. Other than this, information on its expression pattern in developing organs and prenatal roles remains unclear. By in situ hybridization and immunohistochemical staining of E10.5, E12.5, E14.5 and E16.5 mouse embryos, secretin transcript and peptide are widely detected during development. They are expressed in several developing brain regions such as cephalic mesenchyme, cerebellar primordium and choroid plexus. Our findings on secretin expression in the cerebellar primordium are consistent with previous reports that both secretin transcript and peptide were detected in the cerebellum in adult rodents. In the developing intestine, however, secretin expression is different from previous report that the peptide is formed in the inner circular muscle rather than in the epithelial villi lining. Other than these organs, secretin is also detected in the developing heart including the ventricular epicardium and myocardium and certain structures of the developing kidney like ureteric bud, collecting duct and glomerulus. Localizations of secretin in distinct cell-types within the developing heart and kidney have provided novel information which RT – PCR and Northern blot analyses were unable to demonstrate in the past. In summary, the wide distribution of secretin in developing embryos strongly suggests for its functional role of in embryonic development.-
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/regpepen_HK
dc.relation.ispartofRegulatory Peptidesen_HK
dc.rightsRegulatory Peptides. Copyright © Elsevier BV.en_HK
dc.titleSecretin is widely expressed during mouse embryonic developmenten_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0167-0115&volume=130&issue=3&spage=176&epage=&date=2006&atitle=Secretin+is+widely+expressed+during+mouse+embryonic+developmenten_HK
dc.identifier.emailSham, MH: mhsham@hkucc.hku.hken_HK
dc.identifier.emailChow, BKC: bkcc@hkusua.hku.hken_HK
dc.identifier.authoritySham, MH=rp00380en_HK
dc.identifier.authorityChow, BKC=rp00681en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.regpep.2005.06.011-
dc.identifier.hkuros123598en_HK
dc.identifier.hkuros157548-
dc.identifier.hkuros103156-
dc.identifier.volume130en_HK
dc.identifier.issue3en_HK
dc.identifier.spage176en_HK

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