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Conference Paper: Prostate Stem Cell Antigen is a genetic indicator for development of gestational trophoblastic neoplasia

TitleProstate Stem Cell Antigen is a genetic indicator for development of gestational trophoblastic neoplasia
Authors
Issue Date2006
PublisherAmerican Association for Cancer Research
Citation
The 97th AACR Annual Meeting, Washington, D.C., 1-5 April 2006. In Cancer Research, 2006, v. 66 n. 8S, p. 216 Abstract no. 915 How to Cite?
AbstractObjectives: Hydatidiform mole (HM) is the most common type of gestational trophoblastic diseases (GTD). HM can be considered as abnormal conceptuses capable of developing persistent disease or gestational trophoblastic neoplasia (GTN) requiring chemotherapy in a portion of cases. Few biological parameters, except serial HCG assays, have been found useful in predicting the progress of HM to GTN. Methods: Differential expression analysis was performed to identifiy genes that may play a role in development of GTN. HM that spontaneously regressed and that subsequently developed metastatic GTN was compared using the Stanford Human cDNA chip (41, 421 cDNA features). Verification by quantitative RNA analysis by Real-time PCR and immunohistochemical analysis was performed in 23 complete HM genotyped by microsatellite analysis and chromosome in situ hybridization analysis. Results: Approximately 70 differentially expressed genes with ratio more than 3 were identified. They were involved in cell growth, substance transport, anti-coagulation, higher invasive potential and lower metabolism. Four genes were chosen for quantitative RNA analysis, including prostate stem cell antigen (PSCA, p=0.037), aquaporin 3 (AQP3, p=0.455), transforming growth factor beta 2 (TGFB2, p=0.164) and retinol binding protein 1 (RBP1, p=0.128). Up-regulation of PSCA in GTN was further confirmed with immunohistochemical analysis (p=0.0273). Conclusion: Over-expression of PSCA was associated with development of GTN. Stem cells may share cellular characteristics of cancer cells such as capacity of self renewal. Further study on PSCA in GTN may provide a better understanding of its pathogenesis. The potential application of PSCA in management of patient with HM may be explored.
Persistent Identifierhttp://hdl.handle.net/10722/95545
ISSN
2014 Impact Factor: 9.329
2013 SCImago Journal Rankings: 5.627

 

DC FieldValueLanguage
dc.contributor.authorFeng, Hen_HK
dc.contributor.authorTsao, GSWen_HK
dc.contributor.authorNgan, HYSen_HK
dc.contributor.authorXue, Wen_HK
dc.contributor.authorChiu, PMen_HK
dc.contributor.authorKwan, HSen_HK
dc.contributor.authorShih, SMen_HK
dc.contributor.authorCheung, ANYen_HK
dc.date.accessioned2010-09-25T16:05:38Z-
dc.date.available2010-09-25T16:05:38Z-
dc.date.issued2006en_HK
dc.identifier.citationThe 97th AACR Annual Meeting, Washington, D.C., 1-5 April 2006. In Cancer Research, 2006, v. 66 n. 8S, p. 216 Abstract no. 915-
dc.identifier.issn0008-5472-
dc.identifier.urihttp://hdl.handle.net/10722/95545-
dc.description.abstractObjectives: Hydatidiform mole (HM) is the most common type of gestational trophoblastic diseases (GTD). HM can be considered as abnormal conceptuses capable of developing persistent disease or gestational trophoblastic neoplasia (GTN) requiring chemotherapy in a portion of cases. Few biological parameters, except serial HCG assays, have been found useful in predicting the progress of HM to GTN. Methods: Differential expression analysis was performed to identifiy genes that may play a role in development of GTN. HM that spontaneously regressed and that subsequently developed metastatic GTN was compared using the Stanford Human cDNA chip (41, 421 cDNA features). Verification by quantitative RNA analysis by Real-time PCR and immunohistochemical analysis was performed in 23 complete HM genotyped by microsatellite analysis and chromosome in situ hybridization analysis. Results: Approximately 70 differentially expressed genes with ratio more than 3 were identified. They were involved in cell growth, substance transport, anti-coagulation, higher invasive potential and lower metabolism. Four genes were chosen for quantitative RNA analysis, including prostate stem cell antigen (PSCA, p=0.037), aquaporin 3 (AQP3, p=0.455), transforming growth factor beta 2 (TGFB2, p=0.164) and retinol binding protein 1 (RBP1, p=0.128). Up-regulation of PSCA in GTN was further confirmed with immunohistochemical analysis (p=0.0273). Conclusion: Over-expression of PSCA was associated with development of GTN. Stem cells may share cellular characteristics of cancer cells such as capacity of self renewal. Further study on PSCA in GTN may provide a better understanding of its pathogenesis. The potential application of PSCA in management of patient with HM may be explored.-
dc.languageengen_HK
dc.publisherAmerican Association for Cancer Research-
dc.relation.ispartofCancer Researchen_HK
dc.titleProstate Stem Cell Antigen is a genetic indicator for development of gestational trophoblastic neoplasiaen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailFeng, H: fengh1@hkucc.hku.hken_HK
dc.identifier.emailTsao, GSW: gswtsao@hkucc.hku.hken_HK
dc.identifier.emailNgan, HYS: hysngan@hkucc.hku.hken_HK
dc.identifier.emailChiu, PM: h9994065@hkusua.hku.hken_HK
dc.identifier.emailCheung, ANY: anycheun@hkucc.hku.hken_HK
dc.identifier.authorityTsao, GSW=rp00399en_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.identifier.hkuros120480en_HK

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