File Download

There are no files associated with this item.

Supplementary

Conference Paper: Extracts from chinese medicinal herb lycium barbarum (gou-qi-zi) as potential neuroprotective agents

TitleExtracts from chinese medicinal herb lycium barbarum (gou-qi-zi) as potential neuroprotective agents
Authors
KeywordsNEUROPROTECTION
BETA AMYLOID
CASPASE-3
ALZHEIMER'S DISEASE
Issue Date2003
PublisherSociety for Neuroscience
Citation
Neuroscience 2003, New Orleans, LA, 8-12 November 2003, Presentation no. 98.6 How to Cite?
AbstractExtracts from many Chinese medicinal herbs have been reported to modulate biological activities. However, only few of them demonstrate neuroprotective effects. Long-term goals of our laboratories are to target novel drugs in therapeutic intervention against neurodegenerative diseases and advance our knowledge of the underlying mechanisms of neuroprotection. Extracts from Lycium barbarum has long been known to nourish liver and exert beneficial effects to eyes. However, little is known about its effects on neurons. Therefore, we aim to study whether extracts from L. barbarum provide NEUROPROTECTION against chemical toxins staurosporine and BETA AMYLOID (Aβ) peptide. In agreement with other reports, human neuroblastoma SH-SY5Y cells exposed to staurosporine and primary cultured rat neurons exposed to Aβ peptide resulted in apoptosis and subsequent necrosis. Pre-treatment of L. barbarum extract from 70°C hot water significantly reduced the release of lactate dehydrogenase (LDH) as well as CASPASE-3 and -2 activities. We have also characterized the chemical composition of the extracts. Polysaccharides play significant roles in neuroprotection. The results suggested that L. barbarum can serve as potential neuroprotection agent against neuronal death in ALZHEIMER'S DISEASE.
Persistent Identifierhttp://hdl.handle.net/10722/95430

 

DC FieldValueLanguage
dc.contributor.authorLeung, SKYen_HK
dc.contributor.authorYu, MSen_HK
dc.contributor.authorYuen, WHen_HK
dc.contributor.authorChe, CMen_HK
dc.contributor.authorFang, Jen_HK
dc.contributor.authorChang, RCCen_HK
dc.date.accessioned2010-09-25T16:02:01Z-
dc.date.available2010-09-25T16:02:01Z-
dc.date.issued2003en_HK
dc.identifier.citationNeuroscience 2003, New Orleans, LA, 8-12 November 2003, Presentation no. 98.6-
dc.identifier.urihttp://hdl.handle.net/10722/95430-
dc.description.abstractExtracts from many Chinese medicinal herbs have been reported to modulate biological activities. However, only few of them demonstrate neuroprotective effects. Long-term goals of our laboratories are to target novel drugs in therapeutic intervention against neurodegenerative diseases and advance our knowledge of the underlying mechanisms of neuroprotection. Extracts from Lycium barbarum has long been known to nourish liver and exert beneficial effects to eyes. However, little is known about its effects on neurons. Therefore, we aim to study whether extracts from L. barbarum provide NEUROPROTECTION against chemical toxins staurosporine and BETA AMYLOID (Aβ) peptide. In agreement with other reports, human neuroblastoma SH-SY5Y cells exposed to staurosporine and primary cultured rat neurons exposed to Aβ peptide resulted in apoptosis and subsequent necrosis. Pre-treatment of L. barbarum extract from 70°C hot water significantly reduced the release of lactate dehydrogenase (LDH) as well as CASPASE-3 and -2 activities. We have also characterized the chemical composition of the extracts. Polysaccharides play significant roles in neuroprotection. The results suggested that L. barbarum can serve as potential neuroprotection agent against neuronal death in ALZHEIMER'S DISEASE.-
dc.languageengen_HK
dc.publisherSociety for Neuroscience-
dc.relation.ispartofSociety for Neuroscience Annual Meetingen_HK
dc.subjectNEUROPROTECTION-
dc.subjectBETA AMYLOID-
dc.subjectCASPASE-3-
dc.subjectALZHEIMER'S DISEASE-
dc.titleExtracts from chinese medicinal herb lycium barbarum (gou-qi-zi) as potential neuroprotective agentsen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLeung, SKY: saranalk@hkucc.hku.hken_HK
dc.identifier.emailYu, MS: ymsmabel@graduate.hku.hken_HK
dc.identifier.emailYuen, WH: whyuen@srpdfond.comen_HK
dc.identifier.emailChe, CM: cmche@hku.hken_HK
dc.identifier.emailChang, RCC: rccchang@hkucc.hku.hken_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.identifier.authorityChang, RCC=rp00470en_HK
dc.identifier.hkuros85225en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats