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Conference Paper: The control of stem cells in the brain and spinal cord by extracellular nanomatrix system

TitleThe control of stem cells in the brain and spinal cord by extracellular nanomatrix system
Authors
KeywordsRegeneration
CNS
Neural stem cells
Issue Date2009
PublisherSociety for Neuroscience.
Citation
Neuroscience 2009, Chicago, IL, 17-21 October 2009, p. Abstract no. 607.18/A51 How to Cite?
AbstractThe control of cell proliferation, differentiation, propagation and reconstruction is a crucial factor for regenerative medicine. This is particularly the case in the central nervous system where neuronal cells are most resistant to re-growth. There is an ever demanding methodology for controlling the cells implanted in the injury sites of the CNS to avoid detrimental outcomes. We hypothesized that a nano environment of self-assembled nanofiber scaffold (SAPNS) made of natural amino acids could provide a favorable cell living condition which enables better control of stem cell activities. Groups of PC12 cells and neural precursor cells (NPCs) were grown in vitro in a nano environment of SAPNS under different controlled conditions; their physical activities and behavior were monitored and analyzed. We are able to show that altering 1) the cell density; 2) matrix density of SAPNS; and 3) the local nano environment surrounding the PC12 cells and NPCs, is likely to influence cell proliferation, elongation, differentiation and maturation in vitro.
Persistent Identifierhttp://hdl.handle.net/10722/95320

 

DC FieldValueLanguage
dc.contributor.authorEllis-Behnke, RG-
dc.contributor.authorCheung, WH-
dc.contributor.authorTay, DKC-
dc.contributor.authorLiang, Y-
dc.contributor.authorLui Kau, KWF-
dc.contributor.authorSchneider, GE-
dc.contributor.authorSo, KF-
dc.date.accessioned2010-09-25T15:58:29Z-
dc.date.available2010-09-25T15:58:29Z-
dc.date.issued2009-
dc.identifier.citationNeuroscience 2009, Chicago, IL, 17-21 October 2009, p. Abstract no. 607.18/A51-
dc.identifier.urihttp://hdl.handle.net/10722/95320-
dc.description.abstractThe control of cell proliferation, differentiation, propagation and reconstruction is a crucial factor for regenerative medicine. This is particularly the case in the central nervous system where neuronal cells are most resistant to re-growth. There is an ever demanding methodology for controlling the cells implanted in the injury sites of the CNS to avoid detrimental outcomes. We hypothesized that a nano environment of self-assembled nanofiber scaffold (SAPNS) made of natural amino acids could provide a favorable cell living condition which enables better control of stem cell activities. Groups of PC12 cells and neural precursor cells (NPCs) were grown in vitro in a nano environment of SAPNS under different controlled conditions; their physical activities and behavior were monitored and analyzed. We are able to show that altering 1) the cell density; 2) matrix density of SAPNS; and 3) the local nano environment surrounding the PC12 cells and NPCs, is likely to influence cell proliferation, elongation, differentiation and maturation in vitro.-
dc.languageeng-
dc.publisherSociety for Neuroscience. -
dc.relation.ispartofThe Annual Meeting of Society for Neuroscience-
dc.rightsThe Annual Meeting of Society for Neuroscience. Copyright © Society for Neuroscience.-
dc.subjectRegeneration-
dc.subjectCNS-
dc.subjectNeural stem cells-
dc.titleThe control of stem cells in the brain and spinal cord by extracellular nanomatrix system-
dc.typeConference_Paper-
dc.identifier.emailEllis-Behnke, RG: rutledge@HKUCC.hku.hk-
dc.identifier.emailCheung, WH: sunnycwh@hku.hk-
dc.identifier.emailTay, DKC: dkctay@hkucc.hku.hk-
dc.identifier.emailLiang, Y: yxliang@HKUCC.hku.hk-
dc.identifier.emailLui Kau, KWF: kwflui@HKUCC-COM.hku.hk-
dc.identifier.emailSo, KF: hrmaskf@hkucc.hku.hk-
dc.identifier.authorityEllis-Behnke, RG=rp00252-
dc.identifier.authorityCheung, WH=rp00246-
dc.identifier.authorityTay, DKC=rp00336-
dc.identifier.authorityLiang, Y=rp00510-
dc.identifier.authoritySo, KF=rp00329-
dc.identifier.hkuros162723-
dc.identifier.spageAbstract no. 607.18/A51-
dc.identifier.epageAbstract no. 607.18/A51-
dc.publisher.placeChicago, IL-

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