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Article: Association of candidate susceptible loci with chronic infection with hepatitis B virus in a Chinese population

TitleAssociation of candidate susceptible loci with chronic infection with hepatitis B virus in a Chinese population
Authors
KeywordsDisease prevalence
Genetic susceptibility
Hepatitis B virus
Multifactor dimensionality reduction
PCR-RFLP
Issue Date2010
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/32763
Citation
Journal Of Medical Virology, 2010, v. 82 n. 3, p. 371-378 How to Cite?
AbstractA number of genetic loci have been proposed to be associated with persistent hepatitis B virus (HBV) infection. This study aimed to evaluate the association and interaction of susceptible genes with HBV persistence in a Chinese population. A total of 17 polymorphisms in 9 candidate genes were studied in 361 Chinese chronic hepatitis B patients and 304 patients who recovered spontaneously. Distributions of susceptible polymorphisms were examined in healthy Chinese and Caucasian populations. Gene-gene interactions were tested by the multifactor dimensionality reduction (MDR) method. The TNF -308 G/G genotype and G allele, IL-10RB codon 47 A allele, and MCP-1 -2518 G/G genotype and G allele were more frequent in patients than controls (P<0.01, after multiple corrections Pc<0.05), while the frequencies of TNF -308 A/G genotype and IL-10 -592 A/A genotype were significantly higher in controls than in the patient group (Pc<0.05). The frequencies of the risk allele MCP-1 -2518 G and CTLA4 6230 G were much higher in Chinese than in the Caucasian groups (P<0.001). An interaction between CCR5-2459, TNFA-863, IL-10RB codon 47, and MCP-1 -2518 was detected by MDR (P=0.001). The results indicate that genetic determinants may affect the outcome of HBV infection in both independent and synergic manners. © 2010 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/91718
ISSN
2015 Impact Factor: 1.998
2015 SCImago Journal Rankings: 1.015
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong
Funding Information:

Grant sponsor: University of Hong Kong (University Development Fund, partial support).

References

 

DC FieldValueLanguage
dc.contributor.authorChen, DQen_HK
dc.contributor.authorZeng, Yen_HK
dc.contributor.authorZhou, Jen_HK
dc.contributor.authorYang, Len_HK
dc.contributor.authorJiang, Sen_HK
dc.contributor.authorHuang, JDen_HK
dc.contributor.authorLu, Len_HK
dc.contributor.authorZheng, BJen_HK
dc.date.accessioned2010-09-17T10:24:16Z-
dc.date.available2010-09-17T10:24:16Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Medical Virology, 2010, v. 82 n. 3, p. 371-378en_HK
dc.identifier.issn0146-6615en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91718-
dc.description.abstractA number of genetic loci have been proposed to be associated with persistent hepatitis B virus (HBV) infection. This study aimed to evaluate the association and interaction of susceptible genes with HBV persistence in a Chinese population. A total of 17 polymorphisms in 9 candidate genes were studied in 361 Chinese chronic hepatitis B patients and 304 patients who recovered spontaneously. Distributions of susceptible polymorphisms were examined in healthy Chinese and Caucasian populations. Gene-gene interactions were tested by the multifactor dimensionality reduction (MDR) method. The TNF -308 G/G genotype and G allele, IL-10RB codon 47 A allele, and MCP-1 -2518 G/G genotype and G allele were more frequent in patients than controls (P<0.01, after multiple corrections Pc<0.05), while the frequencies of TNF -308 A/G genotype and IL-10 -592 A/A genotype were significantly higher in controls than in the patient group (Pc<0.05). The frequencies of the risk allele MCP-1 -2518 G and CTLA4 6230 G were much higher in Chinese than in the Caucasian groups (P<0.001). An interaction between CCR5-2459, TNFA-863, IL-10RB codon 47, and MCP-1 -2518 was detected by MDR (P=0.001). The results indicate that genetic determinants may affect the outcome of HBV infection in both independent and synergic manners. © 2010 Wiley-Liss, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/32763en_HK
dc.relation.ispartofJournal of Medical Virologyen_HK
dc.subjectDisease prevalenceen_HK
dc.subjectGenetic susceptibilityen_HK
dc.subjectHepatitis B virusen_HK
dc.subjectMultifactor dimensionality reductionen_HK
dc.subjectPCR-RFLPen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAsian Continental Ancestry Groupen_HK
dc.subject.meshEuropean Continental Ancestry Groupen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Frequencyen_HK
dc.subject.meshGenetic Predisposition to Diseaseen_HK
dc.subject.meshGenotypeen_HK
dc.subject.meshHepatitis B, Chronic - geneticsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPoint Mutationen_HK
dc.subject.meshPolymorphism, Geneticen_HK
dc.titleAssociation of candidate susceptible loci with chronic infection with hepatitis B virus in a Chinese populationen_HK
dc.typeArticleen_HK
dc.identifier.emailZhou, J:jiezhou@hku.hken_HK
dc.identifier.emailHuang, JD:jdhuang@hkucc.hku.hken_HK
dc.identifier.emailLu, L:liweilu@hkucc.hku.hken_HK
dc.identifier.emailZheng, BJ:bzheng@hkucc.hku.hken_HK
dc.identifier.authorityZhou, J=rp01412en_HK
dc.identifier.authorityHuang, JD=rp00451en_HK
dc.identifier.authorityLu, L=rp00477en_HK
dc.identifier.authorityZheng, BJ=rp00353en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/jmv.21716en_HK
dc.identifier.pmid20087947-
dc.identifier.scopuseid_2-s2.0-75449084025en_HK
dc.identifier.hkuros175100-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-75449084025&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume82en_HK
dc.identifier.issue3en_HK
dc.identifier.spage371en_HK
dc.identifier.epage378en_HK
dc.identifier.eissn1096-9071-
dc.identifier.isiWOS:000273955000003-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChen, DQ=26634742000en_HK
dc.identifier.scopusauthoridZeng, Y=36985939000en_HK
dc.identifier.scopusauthoridZhou, J=7405550443en_HK
dc.identifier.scopusauthoridYang, L=8421266200en_HK
dc.identifier.scopusauthoridJiang, S=7404453146en_HK
dc.identifier.scopusauthoridHuang, JD=8108660600en_HK
dc.identifier.scopusauthoridLu, L=7403963552en_HK
dc.identifier.scopusauthoridZheng, BJ=7201780588en_HK

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