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Article: Selective elevation of adiponectin production by the natural compounds derived from a medicinal herb alleviates insulin resistance and glucose intolerance in obese mice

TitleSelective elevation of adiponectin production by the natural compounds derived from a medicinal herb alleviates insulin resistance and glucose intolerance in obese mice
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2009
PublisherThe Endocrine Society. The Journal's web site is located at http://endo.endojournals.org
Citation
Endocrinology, 2009, v. 150 n. 2, p. 625-633 How to Cite?
AbstractAdiponectin is an adipocyte-derived insulin-sensitizing hormone with antidiabetic, antiinflammatory, and antiatherosclerotic properties. A decreased serum level of adiponectin in obesity has been identified as an independent risk factor for diabetes and cardiovascular complications, suggesting that pharmacological intervention aimed at elevating adiponectin production might hold promise for the treatment and/or prevention of these diseases. Here we report the identification of two structurally related natural compounds (astragaloside II and isoastragaloside I) from the medicinal herb Radix Astragali that possess such an activity. Astragaloside II and isoastragaloside I selectively increased adiponectin secretion in primary adipocytes without any obvious effects on a panel of other adipokines. Furthermore, an additive effect on induction of adiponectin production was observed between these two compounds and rosiglitazone, a thiazolidinedione class of insulin-sensitizing drugs. Chronic administration of astragaloside II and isoastragaloside I in both dietary and genetic obese mice significantly elevated serum levels of total adiponectin and selectively increased the composition of its high molecular weight oligomeric complex. These changes were associated with an alleviation of hyperglycemia, glucose intolerance, and insulin resistance. By contrast, the beneficial effects of these two compounds on insulin sensitivity and glucose metabolism were diminished in adiponectin knockout mice. In conclusion, our results suggest that pharmacological elevation of circulating adiponectin alone is sufficient to ameliorate insulin resistance and diabetes and support the use of adiponectin as a biomarker for future drug discovery. The two natural compounds might provide the lead as a novel class of therapeutics for obesity-related diseases. Copyright © 2009 by The Endocrine Society.
Persistent Identifierhttp://hdl.handle.net/10722/91678
ISSN
2015 Impact Factor: 4.159
2015 SCImago Journal Rankings: 2.363
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Council of Hong Kong
National Natural Science Foundation of ChinaN_HKU727/05
30518004
National 973 program of China2006CB503908
University of Hong Kong
U.S. National Institutes of HealthHL-51586
Funding Information:

This work was supported by a joint Research Scheme between the Research Grant Council of Hong Kong and the National Natural Science Foundation of China (Project No. N_HKU727/05 and 30518004), the National 973 program of China (2006CB503908), and its matching funding from the University of Hong Kong. Adiponectin knockout mice were kindly provided by Dr. Lawrence Chan at Baylor College of Medicine, who generated these mice with the support of the U.S. National Institutes of Health Grant HL-51586.

References

 

DC FieldValueLanguage
dc.contributor.authorXu, Aen_HK
dc.contributor.authorWang, Hen_HK
dc.contributor.authorHoo, RLCen_HK
dc.contributor.authorSweeney, Gen_HK
dc.contributor.authorVanhoutte, PMen_HK
dc.contributor.authorWang, Yen_HK
dc.contributor.authorWu, Den_HK
dc.contributor.authorChu, Wen_HK
dc.contributor.authorQin, Gen_HK
dc.contributor.authorLam, KSLen_HK
dc.date.accessioned2010-09-17T10:23:13Z-
dc.date.available2010-09-17T10:23:13Z-
dc.date.issued2009en_HK
dc.identifier.citationEndocrinology, 2009, v. 150 n. 2, p. 625-633en_HK
dc.identifier.issn0013-7227en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91678-
dc.description.abstractAdiponectin is an adipocyte-derived insulin-sensitizing hormone with antidiabetic, antiinflammatory, and antiatherosclerotic properties. A decreased serum level of adiponectin in obesity has been identified as an independent risk factor for diabetes and cardiovascular complications, suggesting that pharmacological intervention aimed at elevating adiponectin production might hold promise for the treatment and/or prevention of these diseases. Here we report the identification of two structurally related natural compounds (astragaloside II and isoastragaloside I) from the medicinal herb Radix Astragali that possess such an activity. Astragaloside II and isoastragaloside I selectively increased adiponectin secretion in primary adipocytes without any obvious effects on a panel of other adipokines. Furthermore, an additive effect on induction of adiponectin production was observed between these two compounds and rosiglitazone, a thiazolidinedione class of insulin-sensitizing drugs. Chronic administration of astragaloside II and isoastragaloside I in both dietary and genetic obese mice significantly elevated serum levels of total adiponectin and selectively increased the composition of its high molecular weight oligomeric complex. These changes were associated with an alleviation of hyperglycemia, glucose intolerance, and insulin resistance. By contrast, the beneficial effects of these two compounds on insulin sensitivity and glucose metabolism were diminished in adiponectin knockout mice. In conclusion, our results suggest that pharmacological elevation of circulating adiponectin alone is sufficient to ameliorate insulin resistance and diabetes and support the use of adiponectin as a biomarker for future drug discovery. The two natural compounds might provide the lead as a novel class of therapeutics for obesity-related diseases. Copyright © 2009 by The Endocrine Society.en_HK
dc.languageengen_HK
dc.publisherThe Endocrine Society. The Journal's web site is located at http://endo.endojournals.orgen_HK
dc.relation.ispartofEndocrinologyen_HK
dc.rightsEndocrinology. Copyright © The Endocrine Society.-
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.titleSelective elevation of adiponectin production by the natural compounds derived from a medicinal herb alleviates insulin resistance and glucose intolerance in obese miceen_HK
dc.typeArticleen_HK
dc.identifier.emailXu, A: amxu@hkucc.hku.hken_HK
dc.identifier.emailHoo, RLC: rubyhoo@hkucc.hku.hken_HK
dc.identifier.emailVanhoutte, PM: vanhoutt@hku.hken_HK
dc.identifier.emailWang, Y: yuwanghk@hku.hken_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.authorityXu, A=rp00485en_HK
dc.identifier.authorityHoo, RLC=rp01334en_HK
dc.identifier.authorityVanhoutte, PM=rp00238en_HK
dc.identifier.authorityWang, Y=rp00239en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1210/en.2008-0999en_HK
dc.identifier.pmid18927219-
dc.identifier.pmcidPMC2732290-
dc.identifier.scopuseid_2-s2.0-59649117072en_HK
dc.identifier.hkuros155052-
dc.identifier.hkuros226343-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-59649117072&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume150en_HK
dc.identifier.issue2en_HK
dc.identifier.spage625en_HK
dc.identifier.epage633en_HK
dc.identifier.isiWOS:000262851200009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridXu, A=7202655409en_HK
dc.identifier.scopusauthoridWang, H=37086554900en_HK
dc.identifier.scopusauthoridHoo, RLC=6602369766en_HK
dc.identifier.scopusauthoridSweeney, G=7102852659en_HK
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_HK
dc.identifier.scopusauthoridWang, Y=34973733700en_HK
dc.identifier.scopusauthoridWu, D=7404297751en_HK
dc.identifier.scopusauthoridChu, W=25622253400en_HK
dc.identifier.scopusauthoridQin, G=7202860696en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK

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