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Article: Association of a polymorphism in the lipin 1 gene with systolic blood pressure in men
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TitleAssociation of a polymorphism in the lipin 1 gene with systolic blood pressure in men
 
AuthorsOng, KL1
Leung, RYH1
Wong, LYF1
Cherny, SS1
Sham, PC1
Lam, TH1
Lam, KSL1
Cheung, BMY1 2
 
Issue Date2008
 
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/amjhyper
 
CitationAmerican Journal Of Hypertension, 2008, v. 21 n. 5, p. 539-545 [How to Cite?]
DOI: http://dx.doi.org/10.1038/ajh.2008.21
 
AbstractBackground: Lipin 1 plays a role in abdominal obesity, insulin resistance, and hypertriglyceridemia. The gene is located at 2p25.1, a susceptibility locus for hypertension. We studied the association of tagging single-nucleotide polymorphisms (SNPs) in the lipin 1 (LPIN1) gene with hypertension and blood pressure. Methods: Twelve tagging SNPs from the HapMap database were genotyped using Sequenom MassArray in 268 hypertensive subjects and 407 normotensive controls, of whom 268 matched the cases in age and sex. Results: None of the tagging SNPs were found to be associated with hypertension after correcting for multiple testing, although carriers of the minor allele of rs10520097 had nominally lower odds for hypertension (P = 0.014). After excluding subjects who were on antihypertensive medications, the minor allele of rs10495584 was nominally associated with lower mean systolic and diastolic blood pressures in men (121.1 ± 14.2 and 76.3 ± 10.2 mm Hg vs. 127.4 ± 15.2 and 80.1 ± 10.5 mm Hg, P = 0.002 and 0.007, respectively), but not in women (P > 0.05). The association of rs10495584 with systolic blood pressure in men remained significant after correcting for multiple testing and adjustment for age, waist circumference, insulin resistance, triglyceride, and high-density lipoprotein (HDL) cholesterol (β = -0.158, P = 0.005). An analysis of statistically similar SNPs (ssSNPs) in the regions surrounding rs10495584 suggested that its effect may be caused by its high linkage disequilibrium (LD) with the SNP, rs11524, in which the major allele forms an exonic splicing silencer sequence. Conclusion: Our study provides further evidence that lipin 1 may play a role in blood pressure regulation, especially in men. © 2008 American Journal of Hypertension, Ltd.
 
ISSN0895-7061
2013 Impact Factor: 3.402
 
DOIhttp://dx.doi.org/10.1038/ajh.2008.21
 
ISI Accession Number IDWOS:000255009000015
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorOng, KL
 
dc.contributor.authorLeung, RYH
 
dc.contributor.authorWong, LYF
 
dc.contributor.authorCherny, SS
 
dc.contributor.authorSham, PC
 
dc.contributor.authorLam, TH
 
dc.contributor.authorLam, KSL
 
dc.contributor.authorCheung, BMY
 
dc.date.accessioned2010-09-17T10:22:40Z
 
dc.date.available2010-09-17T10:22:40Z
 
dc.date.issued2008
 
dc.description.abstractBackground: Lipin 1 plays a role in abdominal obesity, insulin resistance, and hypertriglyceridemia. The gene is located at 2p25.1, a susceptibility locus for hypertension. We studied the association of tagging single-nucleotide polymorphisms (SNPs) in the lipin 1 (LPIN1) gene with hypertension and blood pressure. Methods: Twelve tagging SNPs from the HapMap database were genotyped using Sequenom MassArray in 268 hypertensive subjects and 407 normotensive controls, of whom 268 matched the cases in age and sex. Results: None of the tagging SNPs were found to be associated with hypertension after correcting for multiple testing, although carriers of the minor allele of rs10520097 had nominally lower odds for hypertension (P = 0.014). After excluding subjects who were on antihypertensive medications, the minor allele of rs10495584 was nominally associated with lower mean systolic and diastolic blood pressures in men (121.1 ± 14.2 and 76.3 ± 10.2 mm Hg vs. 127.4 ± 15.2 and 80.1 ± 10.5 mm Hg, P = 0.002 and 0.007, respectively), but not in women (P > 0.05). The association of rs10495584 with systolic blood pressure in men remained significant after correcting for multiple testing and adjustment for age, waist circumference, insulin resistance, triglyceride, and high-density lipoprotein (HDL) cholesterol (β = -0.158, P = 0.005). An analysis of statistically similar SNPs (ssSNPs) in the regions surrounding rs10495584 suggested that its effect may be caused by its high linkage disequilibrium (LD) with the SNP, rs11524, in which the major allele forms an exonic splicing silencer sequence. Conclusion: Our study provides further evidence that lipin 1 may play a role in blood pressure regulation, especially in men. © 2008 American Journal of Hypertension, Ltd.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationAmerican Journal Of Hypertension, 2008, v. 21 n. 5, p. 539-545 [How to Cite?]
DOI: http://dx.doi.org/10.1038/ajh.2008.21
 
dc.identifier.doihttp://dx.doi.org/10.1038/ajh.2008.21
 
dc.identifier.epage545
 
dc.identifier.hkuros142074
 
dc.identifier.hkuros157995
 
dc.identifier.isiWOS:000255009000015
 
dc.identifier.issn0895-7061
2013 Impact Factor: 3.402
 
dc.identifier.issue5
 
dc.identifier.openurl
 
dc.identifier.pmid18437145
 
dc.identifier.scopuseid_2-s2.0-42549092827
 
dc.identifier.spage539
 
dc.identifier.urihttp://hdl.handle.net/10722/91643
 
dc.identifier.volume21
 
dc.languageeng
 
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/amjhyper
 
dc.publisher.placeUnited States
 
dc.relation.ispartofAmerican Journal of Hypertension
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAged
 
dc.subject.meshBlood Pressure - genetics
 
dc.subject.meshHypertension - genetics - physiopathology
 
dc.subject.meshNuclear Proteins - genetics
 
dc.subject.meshPolymorphism, Single Nucleotide
 
dc.titleAssociation of a polymorphism in the lipin 1 gene with systolic blood pressure in men
 
dc.typeArticle
 
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<contributor.author>Sham, PC</contributor.author>
<contributor.author>Lam, TH</contributor.author>
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<contributor.author>Cheung, BMY</contributor.author>
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<description.abstract>Background: Lipin 1 plays a role in abdominal obesity, insulin resistance, and hypertriglyceridemia. The gene is located at 2p25.1, a susceptibility locus for hypertension. We studied the association of tagging single-nucleotide polymorphisms (SNPs) in the lipin 1 (LPIN1) gene with hypertension and blood pressure. Methods: Twelve tagging SNPs from the HapMap database were genotyped using Sequenom MassArray in 268 hypertensive subjects and 407 normotensive controls, of whom 268 matched the cases in age and sex. Results: None of the tagging SNPs were found to be associated with hypertension after correcting for multiple testing, although carriers of the minor allele of rs10520097 had nominally lower odds for hypertension (P = 0.014). After excluding subjects who were on antihypertensive medications, the minor allele of rs10495584 was nominally associated with lower mean systolic and diastolic blood pressures in men (121.1 &#177; 14.2 and 76.3 &#177; 10.2 mm Hg vs. 127.4 &#177; 15.2 and 80.1 &#177; 10.5 mm Hg, P = 0.002 and 0.007, respectively), but not in women (P &gt; 0.05). The association of rs10495584 with systolic blood pressure in men remained significant after correcting for multiple testing and adjustment for age, waist circumference, insulin resistance, triglyceride, and high-density lipoprotein (HDL) cholesterol (&#946; = -0.158, P = 0.005). An analysis of statistically similar SNPs (ssSNPs) in the regions surrounding rs10495584 suggested that its effect may be caused by its high linkage disequilibrium (LD) with the SNP, rs11524, in which the major allele forms an exonic splicing silencer sequence. Conclusion: Our study provides further evidence that lipin 1 may play a role in blood pressure regulation, especially in men. &#169; 2008 American Journal of Hypertension, Ltd.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong
  2. University of Birmingham