Article: C-reactive protein is associated with Obstructive sleep apnea independent of visceral obesity
| Title | C-reactive protein is associated with Obstructive sleep apnea independent of visceral obesity | ||||||
|---|---|---|---|---|---|---|---|
| Authors | Lui, MMS3 Lam, JCM3 Mak, HKF1 Xu, A2 Ooi, C1 Lam, DCL3 Mak, JCW3 Khong, PL1 Ip, MSM2 | ||||||
| Keywords | Atherosclerosis C-reactive protein Obesity Obstructive sleep apnea Visceral fat | ||||||
| Issue Date | 2009 | ||||||
| Publisher | American College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.org | ||||||
| Citation | Chest, 2009, v. 135 n. 4, p. 950-956 [How to Cite?] DOI: http://dx.doi.org/10.1378/chest.08-1798 | ||||||
| Abstract | Background: Obstructive sleep apnea (OSA) is associated with adverse cardiovascular outcomes. C-reactive protein (CRP) predicts atherosclerotic complications. Our study evaluates whether OSA is associated with an elevated CRP level, after elimination of known confounders including visceral obesity. Methods: Men without significant chronic medical illness, regular medications, or illness in the preceding 4 weeks were enrolled. Subjects with morbid obesity, newly detected high BP, or fasting glucose were excluded. They underwent polysomnography and MRI of abdomen to quantify visceral fat volume. High-sensitivity CRP levels were measured. Results: 111 men with mean body mass index (BMI) 26.3 ± 3.8 kg/m2 were evaluated. After adjustment for age, smoking, BMI, waist circumference, and sleep efficiency, CRP correlated positively with the apnea-hypopnea index (AHI) [r = 0.35, p < 0.001], duration of O2 saturation < 90% (r = 0.29, p = 0.002), and arousal index (r = 0.32, p = 0.001), and it correlated negatively with minimal O 2 saturation (r =- 0.29, p = 0.002). These correlations were consistent when adjustment was made for MRI visceral fat volume instead of waist circumference. In the regression model, significant predictors of CRP included AHI, waist circumference, and triglyc- erides (adjusted R2, 0.33, p = 0.001, p = 0.002, p = 0.018, respectively). Among the 111 subjects, 32 subjects with no or mild OSA (AHI < 15 events/h) were matched with 32 subjects with moderate-to-severe OSA (AHI ≥ 15 events/h) in MRI visceral fat volume. CRP was higher in subjects with moderate-to-severe OSA (median, 1.32; 0.45 to 2.34 mg/L) when compared to subjects with no or mild OSA (median, 0.54; 0.25 to 0.89 mg/L; p = 0.001). Conclusions: In healthy middle-aged men, elevated CRP level is associated with OSA independent of visceral obesity. Copyright © 2009 American College of Chest Physicians. | ||||||
| ISSN | 0012-3692 2011 Impact Factor: 5.25 2011 SCImago Journal Rankings: 0.497 | ||||||
| DOI | http://dx.doi.org/10.1378/chest.08-1798 | ||||||
| ISI Accession Number ID | WOS:000265113800014
Funding Information: This study is supported by a grant from Lee Wing Tat Cardiorespiratory Fund (20000575.20600.400.01) and Hong Kong Research Grants Council grant award (HKU 7582/06M). | ||||||
| References | References in Scopus | ||||||
| Grants | Endothelial damage and atherosclerosis in obstructive sleep apnea: the role of advanced glycation end products |
| dc.contributor.author | Lui, MMS | ||||||
|---|---|---|---|---|---|---|---|
| dc.contributor.author | Lam, JCM | ||||||
| dc.contributor.author | Mak, HKF | ||||||
| dc.contributor.author | Xu, A | ||||||
| dc.contributor.author | Ooi, C | ||||||
| dc.contributor.author | Lam, DCL | ||||||
| dc.contributor.author | Mak, JCW | ||||||
| dc.contributor.author | Khong, PL | ||||||
| dc.contributor.author | Ip, MSM | ||||||
| dc.date.accessioned | 2010-09-17T10:22:28Z | ||||||
| dc.date.available | 2010-09-17T10:22:28Z | ||||||
| dc.date.issued | 2009 | ||||||
| dc.description.abstract | Background: Obstructive sleep apnea (OSA) is associated with adverse cardiovascular outcomes. C-reactive protein (CRP) predicts atherosclerotic complications. Our study evaluates whether OSA is associated with an elevated CRP level, after elimination of known confounders including visceral obesity. Methods: Men without significant chronic medical illness, regular medications, or illness in the preceding 4 weeks were enrolled. Subjects with morbid obesity, newly detected high BP, or fasting glucose were excluded. They underwent polysomnography and MRI of abdomen to quantify visceral fat volume. High-sensitivity CRP levels were measured. Results: 111 men with mean body mass index (BMI) 26.3 ± 3.8 kg/m2 were evaluated. After adjustment for age, smoking, BMI, waist circumference, and sleep efficiency, CRP correlated positively with the apnea-hypopnea index (AHI) [r = 0.35, p < 0.001], duration of O2 saturation < 90% (r = 0.29, p = 0.002), and arousal index (r = 0.32, p = 0.001), and it correlated negatively with minimal O 2 saturation (r =- 0.29, p = 0.002). These correlations were consistent when adjustment was made for MRI visceral fat volume instead of waist circumference. In the regression model, significant predictors of CRP included AHI, waist circumference, and triglyc- erides (adjusted R2, 0.33, p = 0.001, p = 0.002, p = 0.018, respectively). Among the 111 subjects, 32 subjects with no or mild OSA (AHI < 15 events/h) were matched with 32 subjects with moderate-to-severe OSA (AHI ≥ 15 events/h) in MRI visceral fat volume. CRP was higher in subjects with moderate-to-severe OSA (median, 1.32; 0.45 to 2.34 mg/L) when compared to subjects with no or mild OSA (median, 0.54; 0.25 to 0.89 mg/L; p = 0.001). Conclusions: In healthy middle-aged men, elevated CRP level is associated with OSA independent of visceral obesity. Copyright © 2009 American College of Chest Physicians. | ||||||
| dc.description.grant | Endothelial damage and atherosclerosis in obstructive sleep apnea: the role of advanced glycation end products | ||||||
| dc.description.grantcode | 82607 | ||||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||||
| dc.identifier.citation | Chest, 2009, v. 135 n. 4, p. 950-956 [How to Cite?] DOI: http://dx.doi.org/10.1378/chest.08-1798 | ||||||
| dc.identifier.doi | http://dx.doi.org/10.1378/chest.08-1798 | ||||||
| dc.identifier.eissn | 1931-3543 | ||||||
| dc.identifier.epage | 956 | ||||||
| dc.identifier.isi | WOS:000265113800014
Funding Information: This study is supported by a grant from Lee Wing Tat Cardiorespiratory Fund (20000575.20600.400.01) and Hong Kong Research Grants Council grant award (HKU 7582/06M). | ||||||
| dc.identifier.issn | 0012-3692 2011 Impact Factor: 5.25 2011 SCImago Journal Rankings: 0.497 | ||||||
| dc.identifier.issue | 4 | ||||||
| dc.identifier.pmid | 19225064 | ||||||
| dc.identifier.scopus | eid_2-s2.0-64749097193 | ||||||
| dc.identifier.spage | 950 | ||||||
| dc.identifier.uri | http://hdl.handle.net/10722/91630 | ||||||
| dc.identifier.volume | 135 | ||||||
| dc.language | eng | ||||||
| dc.publisher | American College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.org | ||||||
| dc.publisher.place | United States | ||||||
| dc.relation.ispartof | Chest | ||||||
| dc.relation.references | References in Scopus | ||||||
| dc.subject.mesh | Adult | ||||||
| dc.subject.mesh | Biological Markers - analysis | ||||||
| dc.subject.mesh | Body Mass Index | ||||||
| dc.subject.mesh | C-Reactive Protein - analysis | ||||||
| dc.subject.mesh | Humans | ||||||
| dc.subject.mesh | Intra-Abdominal Fat | ||||||
| dc.subject.mesh | Male | ||||||
| dc.subject.mesh | Middle Aged | ||||||
| dc.subject.mesh | Regression Analysis | ||||||
| dc.subject.mesh | Sensitivity and Specificity | ||||||
| dc.subject.mesh | Sleep Apnea, Obstructive - metabolism | ||||||
| dc.subject.mesh | Waist Circumference | ||||||
| dc.subject | Atherosclerosis | ||||||
| dc.subject | C-reactive protein | ||||||
| dc.subject | Obesity | ||||||
| dc.subject | Obstructive sleep apnea | ||||||
| dc.subject | Visceral fat | ||||||
| dc.title | C-reactive protein is associated with Obstructive sleep apnea independent of visceral obesity | ||||||
| dc.type | Article |
Author Affiliations
- Research Centre of Heart
- The University of Hong Kong
- Departments of Medicine