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Article: C-reactive protein is associated with Obstructive sleep apnea independent of visceral obesity
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TitleC-reactive protein is associated with Obstructive sleep apnea independent of visceral obesity
 
AuthorsLui, MMS3
Lam, JCM3
Mak, HKF1
Xu, A2
Ooi, C1
Lam, DCL3
Mak, JCW3
Khong, PL1
Ip, MSM2 2
 
KeywordsAtherosclerosis
C-reactive protein
Obesity
Obstructive sleep apnea
Visceral fat
 
Issue Date2009
 
PublisherAmerican College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.org
 
CitationChest, 2009, v. 135 n. 4, p. 950-956 [How to Cite?]
DOI: http://dx.doi.org/10.1378/chest.08-1798
 
AbstractBackground: Obstructive sleep apnea (OSA) is associated with adverse cardiovascular outcomes. C-reactive protein (CRP) predicts atherosclerotic complications. Our study evaluates whether OSA is associated with an elevated CRP level, after elimination of known confounders including visceral obesity. Methods: Men without significant chronic medical illness, regular medications, or illness in the preceding 4 weeks were enrolled. Subjects with morbid obesity, newly detected high BP, or fasting glucose were excluded. They underwent polysomnography and MRI of abdomen to quantify visceral fat volume. High-sensitivity CRP levels were measured. Results: 111 men with mean body mass index (BMI) 26.3 ± 3.8 kg/m2 were evaluated. After adjustment for age, smoking, BMI, waist circumference, and sleep efficiency, CRP correlated positively with the apnea-hypopnea index (AHI) [r = 0.35, p < 0.001], duration of O2 saturation < 90% (r = 0.29, p = 0.002), and arousal index (r = 0.32, p = 0.001), and it correlated negatively with minimal O 2 saturation (r =- 0.29, p = 0.002). These correlations were consistent when adjustment was made for MRI visceral fat volume instead of waist circumference. In the regression model, significant predictors of CRP included AHI, waist circumference, and triglyc- erides (adjusted R2, 0.33, p = 0.001, p = 0.002, p = 0.018, respectively). Among the 111 subjects, 32 subjects with no or mild OSA (AHI < 15 events/h) were matched with 32 subjects with moderate-to-severe OSA (AHI ≥ 15 events/h) in MRI visceral fat volume. CRP was higher in subjects with moderate-to-severe OSA (median, 1.32; 0.45 to 2.34 mg/L) when compared to subjects with no or mild OSA (median, 0.54; 0.25 to 0.89 mg/L; p = 0.001). Conclusions: In healthy middle-aged men, elevated CRP level is associated with OSA independent of visceral obesity. Copyright © 2009 American College of Chest Physicians.
 
ISSN0012-3692
2012 Impact Factor: 5.854
2012 SCImago Journal Rankings: 2.031
 
DOIhttp://dx.doi.org/10.1378/chest.08-1798
 
ISI Accession Number IDWOS:000265113800014
Funding AgencyGrant Number
Lee Wing Tat Cardiorespiratory Fund20000575.20600.400.01
Hong Kong Research Grants CouncilHKU 7582/06M
Funding Information:

This study is supported by a grant from Lee Wing Tat Cardiorespiratory Fund (20000575.20600.400.01) and Hong Kong Research Grants Council grant award (HKU 7582/06M).

 
ReferencesReferences in Scopus
 
GrantsEndothelial damage and atherosclerosis in obstructive sleep apnea: the role of advanced glycation end products
 
DC FieldValue
dc.contributor.authorLui, MMS
 
dc.contributor.authorLam, JCM
 
dc.contributor.authorMak, HKF
 
dc.contributor.authorXu, A
 
dc.contributor.authorOoi, C
 
dc.contributor.authorLam, DCL
 
dc.contributor.authorMak, JCW
 
dc.contributor.authorKhong, PL
 
dc.contributor.authorIp, MSM
 
dc.date.accessioned2010-09-17T10:22:28Z
 
dc.date.available2010-09-17T10:22:28Z
 
dc.date.issued2009
 
dc.description.abstractBackground: Obstructive sleep apnea (OSA) is associated with adverse cardiovascular outcomes. C-reactive protein (CRP) predicts atherosclerotic complications. Our study evaluates whether OSA is associated with an elevated CRP level, after elimination of known confounders including visceral obesity. Methods: Men without significant chronic medical illness, regular medications, or illness in the preceding 4 weeks were enrolled. Subjects with morbid obesity, newly detected high BP, or fasting glucose were excluded. They underwent polysomnography and MRI of abdomen to quantify visceral fat volume. High-sensitivity CRP levels were measured. Results: 111 men with mean body mass index (BMI) 26.3 ± 3.8 kg/m2 were evaluated. After adjustment for age, smoking, BMI, waist circumference, and sleep efficiency, CRP correlated positively with the apnea-hypopnea index (AHI) [r = 0.35, p < 0.001], duration of O2 saturation < 90% (r = 0.29, p = 0.002), and arousal index (r = 0.32, p = 0.001), and it correlated negatively with minimal O 2 saturation (r =- 0.29, p = 0.002). These correlations were consistent when adjustment was made for MRI visceral fat volume instead of waist circumference. In the regression model, significant predictors of CRP included AHI, waist circumference, and triglyc- erides (adjusted R2, 0.33, p = 0.001, p = 0.002, p = 0.018, respectively). Among the 111 subjects, 32 subjects with no or mild OSA (AHI < 15 events/h) were matched with 32 subjects with moderate-to-severe OSA (AHI ≥ 15 events/h) in MRI visceral fat volume. CRP was higher in subjects with moderate-to-severe OSA (median, 1.32; 0.45 to 2.34 mg/L) when compared to subjects with no or mild OSA (median, 0.54; 0.25 to 0.89 mg/L; p = 0.001). Conclusions: In healthy middle-aged men, elevated CRP level is associated with OSA independent of visceral obesity. Copyright © 2009 American College of Chest Physicians.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationChest, 2009, v. 135 n. 4, p. 950-956 [How to Cite?]
DOI: http://dx.doi.org/10.1378/chest.08-1798
 
dc.identifier.doihttp://dx.doi.org/10.1378/chest.08-1798
 
dc.identifier.eissn1931-3543
 
dc.identifier.epage956
 
dc.identifier.isiWOS:000265113800014
Funding AgencyGrant Number
Lee Wing Tat Cardiorespiratory Fund20000575.20600.400.01
Hong Kong Research Grants CouncilHKU 7582/06M
Funding Information:

This study is supported by a grant from Lee Wing Tat Cardiorespiratory Fund (20000575.20600.400.01) and Hong Kong Research Grants Council grant award (HKU 7582/06M).

 
dc.identifier.issn0012-3692
2012 Impact Factor: 5.854
2012 SCImago Journal Rankings: 2.031
 
dc.identifier.issue4
 
dc.identifier.pmid19225064
 
dc.identifier.scopuseid_2-s2.0-64749097193
 
dc.identifier.spage950
 
dc.identifier.urihttp://hdl.handle.net/10722/91630
 
dc.identifier.volume135
 
dc.languageeng
 
dc.publisherAmerican College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.org
 
dc.publisher.placeUnited States
 
dc.relation.ispartofChest
 
dc.relation.projectEndothelial damage and atherosclerosis in obstructive sleep apnea: the role of advanced glycation end products
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdult
 
dc.subject.meshBiological Markers - analysis
 
dc.subject.meshBody Mass Index
 
dc.subject.meshC-Reactive Protein - analysis
 
dc.subject.meshHumans
 
dc.subject.meshIntra-Abdominal Fat
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshRegression Analysis
 
dc.subject.meshSensitivity and Specificity
 
dc.subject.meshSleep Apnea, Obstructive - metabolism
 
dc.subject.meshWaist Circumference
 
dc.subjectAtherosclerosis
 
dc.subjectC-reactive protein
 
dc.subjectObesity
 
dc.subjectObstructive sleep apnea
 
dc.subjectVisceral fat
 
dc.titleC-reactive protein is associated with Obstructive sleep apnea independent of visceral obesity
 
dc.typeArticle
 
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<contributor.author>Lam, DCL</contributor.author>
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<description.abstract>Background: Obstructive sleep apnea (OSA) is associated with adverse cardiovascular outcomes. C-reactive protein (CRP) predicts atherosclerotic complications. Our study evaluates whether OSA is associated with an elevated CRP level, after elimination of known confounders including visceral obesity. Methods: Men without significant chronic medical illness, regular medications, or illness in the preceding 4 weeks were enrolled. Subjects with morbid obesity, newly detected high BP, or fasting glucose were excluded. They underwent polysomnography and MRI of abdomen to quantify visceral fat volume. High-sensitivity CRP levels were measured. Results: 111 men with mean body mass index (BMI) 26.3 &#177; 3.8 kg/m2 were evaluated. After adjustment for age, smoking, BMI, waist circumference, and sleep efficiency, CRP correlated positively with the apnea-hypopnea index (AHI) [r = 0.35, p &lt; 0.001], duration of O2 saturation &lt; 90% (r = 0.29, p = 0.002), and arousal index (r = 0.32, p = 0.001), and it correlated negatively with minimal O 2 saturation (r =- 0.29, p = 0.002). These correlations were consistent when adjustment was made for MRI visceral fat volume instead of waist circumference. In the regression model, significant predictors of CRP included AHI, waist circumference, and triglyc- erides (adjusted R2, 0.33, p = 0.001, p = 0.002, p = 0.018, respectively). Among the 111 subjects, 32 subjects with no or mild OSA (AHI &lt; 15 events/h) were matched with 32 subjects with moderate-to-severe OSA (AHI &#8805; 15 events/h) in MRI visceral fat volume. CRP was higher in subjects with moderate-to-severe OSA (median, 1.32; 0.45 to 2.34 mg/L) when compared to subjects with no or mild OSA (median, 0.54; 0.25 to 0.89 mg/L; p = 0.001). Conclusions: In healthy middle-aged men, elevated CRP level is associated with OSA independent of visceral obesity. Copyright &#169; 2009 American College of Chest Physicians.</description.abstract>
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Author Affiliations
  1. Research Centre of Heart
  2. The University of Hong Kong
  3. Departments of Medicine