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Article: C-reactive protein is associated with Obstructive sleep apnea independent of visceral obesity

TitleC-reactive protein is associated with Obstructive sleep apnea independent of visceral obesity
Authors
KeywordsAtherosclerosis
C-reactive protein
Obesity
Obstructive sleep apnea
Visceral fat
Issue Date2009
PublisherAmerican College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.org
Citation
Chest, 2009, v. 135 n. 4, p. 950-956 How to Cite?
AbstractBackground: Obstructive sleep apnea (OSA) is associated with adverse cardiovascular outcomes. C-reactive protein (CRP) predicts atherosclerotic complications. Our study evaluates whether OSA is associated with an elevated CRP level, after elimination of known confounders including visceral obesity. Methods: Men without significant chronic medical illness, regular medications, or illness in the preceding 4 weeks were enrolled. Subjects with morbid obesity, newly detected high BP, or fasting glucose were excluded. They underwent polysomnography and MRI of abdomen to quantify visceral fat volume. High-sensitivity CRP levels were measured. Results: 111 men with mean body mass index (BMI) 26.3 ± 3.8 kg/m2 were evaluated. After adjustment for age, smoking, BMI, waist circumference, and sleep efficiency, CRP correlated positively with the apnea-hypopnea index (AHI) [r = 0.35, p < 0.001], duration of O2 saturation < 90% (r = 0.29, p = 0.002), and arousal index (r = 0.32, p = 0.001), and it correlated negatively with minimal O 2 saturation (r =- 0.29, p = 0.002). These correlations were consistent when adjustment was made for MRI visceral fat volume instead of waist circumference. In the regression model, significant predictors of CRP included AHI, waist circumference, and triglyc- erides (adjusted R2, 0.33, p = 0.001, p = 0.002, p = 0.018, respectively). Among the 111 subjects, 32 subjects with no or mild OSA (AHI < 15 events/h) were matched with 32 subjects with moderate-to-severe OSA (AHI ≥ 15 events/h) in MRI visceral fat volume. CRP was higher in subjects with moderate-to-severe OSA (median, 1.32; 0.45 to 2.34 mg/L) when compared to subjects with no or mild OSA (median, 0.54; 0.25 to 0.89 mg/L; p = 0.001). Conclusions: In healthy middle-aged men, elevated CRP level is associated with OSA independent of visceral obesity. Copyright © 2009 American College of Chest Physicians.
Persistent Identifierhttp://hdl.handle.net/10722/91630
ISSN
2014 Impact Factor: 7.483
2013 SCImago Journal Rankings: 3.432
ISI Accession Number ID
Funding AgencyGrant Number
Lee Wing Tat Cardiorespiratory Fund20000575.20600.400.01
Hong Kong Research Grants CouncilHKU 7582/06M
Funding Information:

This study is supported by a grant from Lee Wing Tat Cardiorespiratory Fund (20000575.20600.400.01) and Hong Kong Research Grants Council grant award (HKU 7582/06M).

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorLui, MMSen_HK
dc.contributor.authorLam, JCMen_HK
dc.contributor.authorMak, HKFen_HK
dc.contributor.authorXu, Aen_HK
dc.contributor.authorOoi, Cen_HK
dc.contributor.authorLam, DCLen_HK
dc.contributor.authorMak, JCWen_HK
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorIp, MSMen_HK
dc.date.accessioned2010-09-17T10:22:28Z-
dc.date.available2010-09-17T10:22:28Z-
dc.date.issued2009en_HK
dc.identifier.citationChest, 2009, v. 135 n. 4, p. 950-956en_HK
dc.identifier.issn0012-3692en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91630-
dc.description.abstractBackground: Obstructive sleep apnea (OSA) is associated with adverse cardiovascular outcomes. C-reactive protein (CRP) predicts atherosclerotic complications. Our study evaluates whether OSA is associated with an elevated CRP level, after elimination of known confounders including visceral obesity. Methods: Men without significant chronic medical illness, regular medications, or illness in the preceding 4 weeks were enrolled. Subjects with morbid obesity, newly detected high BP, or fasting glucose were excluded. They underwent polysomnography and MRI of abdomen to quantify visceral fat volume. High-sensitivity CRP levels were measured. Results: 111 men with mean body mass index (BMI) 26.3 ± 3.8 kg/m2 were evaluated. After adjustment for age, smoking, BMI, waist circumference, and sleep efficiency, CRP correlated positively with the apnea-hypopnea index (AHI) [r = 0.35, p < 0.001], duration of O2 saturation < 90% (r = 0.29, p = 0.002), and arousal index (r = 0.32, p = 0.001), and it correlated negatively with minimal O 2 saturation (r =- 0.29, p = 0.002). These correlations were consistent when adjustment was made for MRI visceral fat volume instead of waist circumference. In the regression model, significant predictors of CRP included AHI, waist circumference, and triglyc- erides (adjusted R2, 0.33, p = 0.001, p = 0.002, p = 0.018, respectively). Among the 111 subjects, 32 subjects with no or mild OSA (AHI < 15 events/h) were matched with 32 subjects with moderate-to-severe OSA (AHI ≥ 15 events/h) in MRI visceral fat volume. CRP was higher in subjects with moderate-to-severe OSA (median, 1.32; 0.45 to 2.34 mg/L) when compared to subjects with no or mild OSA (median, 0.54; 0.25 to 0.89 mg/L; p = 0.001). Conclusions: In healthy middle-aged men, elevated CRP level is associated with OSA independent of visceral obesity. Copyright © 2009 American College of Chest Physicians.en_HK
dc.languageengen_HK
dc.publisherAmerican College of Chest Physicians. The Journal's web site is located at http://www.chestjournal.orgen_HK
dc.relation.ispartofChesten_HK
dc.subjectAtherosclerosisen_HK
dc.subjectC-reactive proteinen_HK
dc.subjectObesityen_HK
dc.subjectObstructive sleep apneaen_HK
dc.subjectVisceral faten_HK
dc.subject.meshAdulten_HK
dc.subject.meshBiological Markers - analysisen_HK
dc.subject.meshBody Mass Indexen_HK
dc.subject.meshC-Reactive Protein - analysisen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIntra-Abdominal Faten_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshRegression Analysisen_HK
dc.subject.meshSensitivity and Specificityen_HK
dc.subject.meshSleep Apnea, Obstructive - metabolismen_HK
dc.subject.meshWaist Circumferenceen_HK
dc.titleC-reactive protein is associated with Obstructive sleep apnea independent of visceral obesityen_HK
dc.typeArticleen_HK
dc.identifier.emailMak, HKF:makkf@hkucc.hku.hken_HK
dc.identifier.emailXu, A:amxu@hkucc.hku.hken_HK
dc.identifier.emailLam, DCL:lamcl@hkucc.hku.hken_HK
dc.identifier.emailMak, JCW:judymak@hku.hken_HK
dc.identifier.emailKhong, PL:plkhong@hkucc.hku.hken_HK
dc.identifier.emailIp, MSM:msmip@hku.hken_HK
dc.identifier.authorityMak, HKF=rp00533en_HK
dc.identifier.authorityXu, A=rp00485en_HK
dc.identifier.authorityLam, DCL=rp01345en_HK
dc.identifier.authorityMak, JCW=rp00352en_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.identifier.authorityIp, MSM=rp00347en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1378/chest.08-1798en_HK
dc.identifier.pmid19225064en_HK
dc.identifier.scopuseid_2-s2.0-64749097193en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-64749097193&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume135en_HK
dc.identifier.issue4en_HK
dc.identifier.spage950en_HK
dc.identifier.epage956en_HK
dc.identifier.eissn1931-3543-
dc.identifier.isiWOS:000265113800014-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectEndothelial damage and atherosclerosis in obstructive sleep apnea: the role of advanced glycation end products-
dc.identifier.scopusauthoridLui, MMS=26027035000en_HK
dc.identifier.scopusauthoridLam, JCM=25923453500en_HK
dc.identifier.scopusauthoridMak, HKF=7004699149en_HK
dc.identifier.scopusauthoridXu, A=7202655409en_HK
dc.identifier.scopusauthoridOoi, C=7007084909en_HK
dc.identifier.scopusauthoridLam, DCL=7201749615en_HK
dc.identifier.scopusauthoridMak, JCW=7103323094en_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK
dc.identifier.scopusauthoridIp, MSM=7102423259en_HK

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