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Article: Inflammatory biomarkers associated with obesity and insulin resistance: A focus on lipocalin-2 and adipocyte fatty acid-binding protein

TitleInflammatory biomarkers associated with obesity and insulin resistance: A focus on lipocalin-2 and adipocyte fatty acid-binding protein
Authors
KeywordsAdipocyte fatty acid-binding protein
Adipokine
Cardiovascular disease
Diabetes
Inflammation
Lipocalin-2
Obesity
Issue Date2008
PublisherExpert Reviews Ltd. The Journal's web site is located at http://www.future-drugs.com/loi/eem
Citation
Expert Review Of Endocrinology And Metabolism, 2008, v. 3 n. 1, p. 29-41 How to Cite?
AbstractObesity is an important risk factor for a cluster of metabolic and cardiovascular diseases, oincluding insulin resistance, Type 2 diabetes, nonalcoholic fatty liver disease and atherosclerosis. Systemic low-grade inflammation, characterized by elevated circulating concentrations of proinflammatory factors, has recently been proposed to be a key mediator that links obesity with its medical complications. Adipose tissue is now recognized as the major contributor to systemic inflammation associated with obesity. As obesity develops, adipose tissue is infiltrated with activated macrophages. The 'inflamed' adipose tissue secretes a large number of proinflammatory adipokines and/or cytokines, which can act either in an autocrine manner to perpetuate local inflammation or in an endocrine manner to induce insulin resistance and endothelial dysfunction. In this review, we summarize recent advances in several newly identified adipose tissue-derived inflammatory factors, with the focus on lipocalin-2 and adipocyte fatty acid-binding protein (A-FABP). Both lipocalin-2 and A-FABP possess lipid-binding properties and are important integrators of metabolic and inflammatory pathways. A growing body of evidence from experimental, epidemiological and genetic studies suggests that both lipocalin-2 and A-FABP represent a novel class of serum biomarkers for risk prediction and therapeutic intervention of obesity-related medical complications. © 2008 Future Drugs Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/91616
ISSN
2015 SCImago Journal Rankings: 0.319
References

 

DC FieldValueLanguage
dc.contributor.authorHoo, RLCen_HK
dc.contributor.authorYeung, DCYen_HK
dc.contributor.authorLam, KSLen_HK
dc.contributor.authorXu, Aen_HK
dc.date.accessioned2010-09-17T10:22:15Z-
dc.date.available2010-09-17T10:22:15Z-
dc.date.issued2008en_HK
dc.identifier.citationExpert Review Of Endocrinology And Metabolism, 2008, v. 3 n. 1, p. 29-41en_HK
dc.identifier.issn1744-6651en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91616-
dc.description.abstractObesity is an important risk factor for a cluster of metabolic and cardiovascular diseases, oincluding insulin resistance, Type 2 diabetes, nonalcoholic fatty liver disease and atherosclerosis. Systemic low-grade inflammation, characterized by elevated circulating concentrations of proinflammatory factors, has recently been proposed to be a key mediator that links obesity with its medical complications. Adipose tissue is now recognized as the major contributor to systemic inflammation associated with obesity. As obesity develops, adipose tissue is infiltrated with activated macrophages. The 'inflamed' adipose tissue secretes a large number of proinflammatory adipokines and/or cytokines, which can act either in an autocrine manner to perpetuate local inflammation or in an endocrine manner to induce insulin resistance and endothelial dysfunction. In this review, we summarize recent advances in several newly identified adipose tissue-derived inflammatory factors, with the focus on lipocalin-2 and adipocyte fatty acid-binding protein (A-FABP). Both lipocalin-2 and A-FABP possess lipid-binding properties and are important integrators of metabolic and inflammatory pathways. A growing body of evidence from experimental, epidemiological and genetic studies suggests that both lipocalin-2 and A-FABP represent a novel class of serum biomarkers for risk prediction and therapeutic intervention of obesity-related medical complications. © 2008 Future Drugs Ltd.en_HK
dc.languageengen_HK
dc.publisherExpert Reviews Ltd. The Journal's web site is located at http://www.future-drugs.com/loi/eemen_HK
dc.relation.ispartofExpert Review of Endocrinology and Metabolismen_HK
dc.subjectAdipocyte fatty acid-binding proteinen_HK
dc.subjectAdipokineen_HK
dc.subjectCardiovascular diseaseen_HK
dc.subjectDiabetesen_HK
dc.subjectInflammationen_HK
dc.subjectLipocalin-2en_HK
dc.subjectObesityen_HK
dc.titleInflammatory biomarkers associated with obesity and insulin resistance: A focus on lipocalin-2 and adipocyte fatty acid-binding proteinen_HK
dc.typeArticleen_HK
dc.identifier.emailHoo, RLC:rubyhoo@hkucc.hku.hken_HK
dc.identifier.emailLam, KSL:ksllam@hku.hken_HK
dc.identifier.emailXu, A:amxu@hkucc.hku.hken_HK
dc.identifier.authorityHoo, RLC=rp01334en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.identifier.authorityXu, A=rp00485en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1586/17446651.3.1.29en_HK
dc.identifier.scopuseid_2-s2.0-37549058420en_HK
dc.identifier.hkuros140651-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-37549058420&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume3en_HK
dc.identifier.issue1en_HK
dc.identifier.spage29en_HK
dc.identifier.epage41en_HK
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHoo, RLC=6602369766en_HK
dc.identifier.scopusauthoridYeung, DCY=36869426200en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK
dc.identifier.scopusauthoridXu, A=7202655409en_HK
dc.identifier.citeulike2152684-

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