Article: Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese

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TitlePopulation differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese
AuthorsYang, W1
Ng, P1
Zhao, M1
Hirankarn, N3
Lau, CS1
Mok, CC2
Chan, TM1
Wong, RWS1
Lee, KW4
Mok, MY1
Wong, SN2
Avihingsanon, Y3
Lee, TL1
Ho, MHK1
Lee, PPW1
Wong, WHS1
Lau, YL1
Issue Date2009
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/gene
CitationGenes And Immunity, 2009, v. 10 n. 3, p. 219-226 [How to Cite?]
DOI: http://dx.doi.org/10.1038/gene.2009.1
AbstractIn this study, we compared the association of several newly discovered susceptibility genes for systemic lupus erythematosus (SLE) between populations of European origin and two Asian populations. Using 910 SLE patients and 1440 healthy controls from Chinese living in Hong Kong, and 278 SLE patients and 383 controls in Thailand, we studied association of STAT4, BLK and PXK with the disease. Our data confirmed association of STAT4 (rs7574865, odds ratio (OR) =1.71, P=3.55 × 10-23) and BLK (rs13277113, OR=0.77, P=1.34 × 10-5) with SLE. It was showed that rs7574865 of STAT4 is also linked to hematologic disorders and potentially some other subphenotypes of the disease. More than one genetic variant in STAT4 were found to be associated with the disease independently in our populations (rs7601754, OR=0.59, P=1.39 × 10-9, and P=0.00034 when controlling the effect of rs7574865). With the same set of samples, however, our study did not detect any significant disease association for PXK, a risk factor for populations of European origin (rs6445975, joint P=0.36, OR=1.06, 95% confidence interval: 0.93-1.21). Our study indicates that some of the susceptibility genes for this disease may be population specific.
ISSN1466-4879
2011 Impact Factor: 3.872
2011 SCImago Journal Rankings: 0.631
DOIhttp://dx.doi.org/10.1038/gene.2009.1
ReferencesReferences in Scopus
GrantsAssociation of Gene Copy Number Variations (CNV) in the FCGR locus with Systemic Lupus Erythematosus (SLE)
DC Field
Value
dc.contributor.authorYang, W
dc.contributor.authorNg, P
dc.contributor.authorZhao, M
dc.contributor.authorHirankarn, N
dc.contributor.authorLau, CS
dc.contributor.authorMok, CC
dc.contributor.authorChan, TM
dc.contributor.authorWong, RWS
dc.contributor.authorLee, KW
dc.contributor.authorMok, MY
dc.contributor.authorWong, SN
dc.contributor.authorAvihingsanon, Y
dc.contributor.authorLee, TL
dc.contributor.authorHo, MHK
dc.contributor.authorLee, PPW
dc.contributor.authorWong, WHS
dc.contributor.authorLau, YL
dc.date.accessioned2010-09-17T10:22:02Z
dc.date.available2010-09-17T10:22:02Z
dc.date.issued2009
dc.description.abstractIn this study, we compared the association of several newly discovered susceptibility genes for systemic lupus erythematosus (SLE) between populations of European origin and two Asian populations. Using 910 SLE patients and 1440 healthy controls from Chinese living in Hong Kong, and 278 SLE patients and 383 controls in Thailand, we studied association of STAT4, BLK and PXK with the disease. Our data confirmed association of STAT4 (rs7574865, odds ratio (OR) =1.71, P=3.55 × 10-23) and BLK (rs13277113, OR=0.77, P=1.34 × 10-5) with SLE. It was showed that rs7574865 of STAT4 is also linked to hematologic disorders and potentially some other subphenotypes of the disease. More than one genetic variant in STAT4 were found to be associated with the disease independently in our populations (rs7601754, OR=0.59, P=1.39 × 10-9, and P=0.00034 when controlling the effect of rs7574865). With the same set of samples, however, our study did not detect any significant disease association for PXK, a risk factor for populations of European origin (rs6445975, joint P=0.36, OR=1.06, 95% confidence interval: 0.93-1.21). Our study indicates that some of the susceptibility genes for this disease may be population specific.
dc.description.grantAssociation of Gene Copy Number Variations (CNV) in the FCGR locus with Systemic Lupus Erythematosus (SLE)
dc.description.grantcode97946
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationGenes And Immunity, 2009, v. 10 n. 3, p. 219-226 [How to Cite?]
DOI: http://dx.doi.org/10.1038/gene.2009.1
dc.identifier.citeulike4089029
dc.identifier.doihttp://dx.doi.org/10.1038/gene.2009.1
dc.identifier.eissn1476-5470
dc.identifier.epage226
dc.identifier.hkuros155947
dc.identifier.hkuros162918
dc.identifier.isiWOS:000265961300003
Funding AgencyGrant Number
Shun Tak District Min Yuen Tong of Hong Kong
Edward Sai Kim Hotung Paediatric Education and Research Fund
University Postgraduate Studentship
UGC
UHK200711159155
Funding Information:

This study was partially supported by the Shun Tak District Min Yuen Tong of Hong Kong. PN and MZ were supported by Edward Sai Kim Hotung Paediatric Education and Research Fund, and University Postgraduate Studentship. WY acknowledges support from UGC, UHK (200711159155).

dc.identifier.issn1466-4879
2011 Impact Factor: 3.872
2011 SCImago Journal Rankings: 0.631
dc.identifier.issue3
dc.identifier.pmid19225526
dc.identifier.scopuseid_2-s2.0-67349113436
dc.identifier.spage219
dc.identifier.urihttp://hdl.handle.net/10722/91602
dc.identifier.volume10
dc.languageeng
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/gene
dc.publisher.placeUnited Kingdom
dc.relation.ispartofGenes and Immunity
dc.relation.referencesReferences in Scopus
dc.subject.meshAdult
dc.subject.meshFemale
dc.subject.meshGenetic Predisposition to Disease
dc.subject.meshGenotype
dc.subject.meshHong Kong
dc.subject.meshHumans
dc.subject.meshIntracellular Signaling Peptides and Proteins - genetics
dc.subject.meshLinkage Disequilibrium
dc.subject.meshLupus Erythematosus, Systemic - genetics
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshNerve Tissue Proteins - genetics
dc.subject.meshPolymorphism, Single Nucleotide - genetics
dc.subject.meshProtein-Serine-Threonine Kinases - genetics
dc.subject.meshSTAT4 Transcription Factor - genetics
dc.titlePopulation differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. Tuen Mun Hospital
  3. Chulalongkorn University
  4. Pamela Youde Nethersole Eastern Hospital