File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese
  • Basic View
  • Metadata View
  • XML View
TitlePopulation differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese
 
AuthorsYang, W1
Ng, P1
Zhao, M1
Hirankarn, N3
Lau, CS1
Mok, CC2
Chan, TM1
Wong, RWS1
Lee, KW4
Mok, MY1
Wong, SN2
Avihingsanon, Y3
Lee, TL1
Ho, MHK1
Lee, PPW1
Wong, WHS1
Lau, YL1
 
Issue Date2009
 
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/gene
 
CitationGenes And Immunity, 2009, v. 10 n. 3, p. 219-226 [How to Cite?]
DOI: http://dx.doi.org/10.1038/gene.2009.1
 
AbstractIn this study, we compared the association of several newly discovered susceptibility genes for systemic lupus erythematosus (SLE) between populations of European origin and two Asian populations. Using 910 SLE patients and 1440 healthy controls from Chinese living in Hong Kong, and 278 SLE patients and 383 controls in Thailand, we studied association of STAT4, BLK and PXK with the disease. Our data confirmed association of STAT4 (rs7574865, odds ratio (OR) =1.71, P=3.55 × 10-23) and BLK (rs13277113, OR=0.77, P=1.34 × 10-5) with SLE. It was showed that rs7574865 of STAT4 is also linked to hematologic disorders and potentially some other subphenotypes of the disease. More than one genetic variant in STAT4 were found to be associated with the disease independently in our populations (rs7601754, OR=0.59, P=1.39 × 10-9, and P=0.00034 when controlling the effect of rs7574865). With the same set of samples, however, our study did not detect any significant disease association for PXK, a risk factor for populations of European origin (rs6445975, joint P=0.36, OR=1.06, 95% confidence interval: 0.93-1.21). Our study indicates that some of the susceptibility genes for this disease may be population specific.
 
ISSN1466-4879
2013 Impact Factor: 3.789
 
DOIhttp://dx.doi.org/10.1038/gene.2009.1
 
ISI Accession Number IDWOS:000265961300003
Funding AgencyGrant Number
Shun Tak District Min Yuen Tong of Hong Kong
Edward Sai Kim Hotung Paediatric Education and Research Fund
University Postgraduate Studentship
UGC
UHK200711159155
Funding Information:

This study was partially supported by the Shun Tak District Min Yuen Tong of Hong Kong. PN and MZ were supported by Edward Sai Kim Hotung Paediatric Education and Research Fund, and University Postgraduate Studentship. WY acknowledges support from UGC, UHK (200711159155).

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorYang, W
 
dc.contributor.authorNg, P
 
dc.contributor.authorZhao, M
 
dc.contributor.authorHirankarn, N
 
dc.contributor.authorLau, CS
 
dc.contributor.authorMok, CC
 
dc.contributor.authorChan, TM
 
dc.contributor.authorWong, RWS
 
dc.contributor.authorLee, KW
 
dc.contributor.authorMok, MY
 
dc.contributor.authorWong, SN
 
dc.contributor.authorAvihingsanon, Y
 
dc.contributor.authorLee, TL
 
dc.contributor.authorHo, MHK
 
dc.contributor.authorLee, PPW
 
dc.contributor.authorWong, WHS
 
dc.contributor.authorLau, YL
 
dc.date.accessioned2010-09-17T10:22:02Z
 
dc.date.available2010-09-17T10:22:02Z
 
dc.date.issued2009
 
dc.description.abstractIn this study, we compared the association of several newly discovered susceptibility genes for systemic lupus erythematosus (SLE) between populations of European origin and two Asian populations. Using 910 SLE patients and 1440 healthy controls from Chinese living in Hong Kong, and 278 SLE patients and 383 controls in Thailand, we studied association of STAT4, BLK and PXK with the disease. Our data confirmed association of STAT4 (rs7574865, odds ratio (OR) =1.71, P=3.55 × 10-23) and BLK (rs13277113, OR=0.77, P=1.34 × 10-5) with SLE. It was showed that rs7574865 of STAT4 is also linked to hematologic disorders and potentially some other subphenotypes of the disease. More than one genetic variant in STAT4 were found to be associated with the disease independently in our populations (rs7601754, OR=0.59, P=1.39 × 10-9, and P=0.00034 when controlling the effect of rs7574865). With the same set of samples, however, our study did not detect any significant disease association for PXK, a risk factor for populations of European origin (rs6445975, joint P=0.36, OR=1.06, 95% confidence interval: 0.93-1.21). Our study indicates that some of the susceptibility genes for this disease may be population specific.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationGenes And Immunity, 2009, v. 10 n. 3, p. 219-226 [How to Cite?]
DOI: http://dx.doi.org/10.1038/gene.2009.1
 
dc.identifier.citeulike4089029
 
dc.identifier.doihttp://dx.doi.org/10.1038/gene.2009.1
 
dc.identifier.eissn1476-5470
 
dc.identifier.epage226
 
dc.identifier.hkuros155947
 
dc.identifier.hkuros162918
 
dc.identifier.isiWOS:000265961300003
Funding AgencyGrant Number
Shun Tak District Min Yuen Tong of Hong Kong
Edward Sai Kim Hotung Paediatric Education and Research Fund
University Postgraduate Studentship
UGC
UHK200711159155
Funding Information:

This study was partially supported by the Shun Tak District Min Yuen Tong of Hong Kong. PN and MZ were supported by Edward Sai Kim Hotung Paediatric Education and Research Fund, and University Postgraduate Studentship. WY acknowledges support from UGC, UHK (200711159155).

 
dc.identifier.issn1466-4879
2013 Impact Factor: 3.789
 
dc.identifier.issue3
 
dc.identifier.pmid19225526
 
dc.identifier.scopuseid_2-s2.0-67349113436
 
dc.identifier.spage219
 
dc.identifier.urihttp://hdl.handle.net/10722/91602
 
dc.identifier.volume10
 
dc.languageeng
 
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/gene
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofGenes and Immunity
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdult
 
dc.subject.meshFemale
 
dc.subject.meshGenetic Predisposition to Disease
 
dc.subject.meshGenotype
 
dc.subject.meshHong Kong
 
dc.subject.meshHumans
 
dc.subject.meshIntracellular Signaling Peptides and Proteins - genetics
 
dc.subject.meshLinkage Disequilibrium
 
dc.subject.meshLupus Erythematosus, Systemic - genetics
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshNerve Tissue Proteins - genetics
 
dc.subject.meshPolymorphism, Single Nucleotide - genetics
 
dc.subject.meshProtein-Serine-Threonine Kinases - genetics
 
dc.subject.meshSTAT4 Transcription Factor - genetics
 
dc.titlePopulation differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Yang, W</contributor.author>
<contributor.author>Ng, P</contributor.author>
<contributor.author>Zhao, M</contributor.author>
<contributor.author>Hirankarn, N</contributor.author>
<contributor.author>Lau, CS</contributor.author>
<contributor.author>Mok, CC</contributor.author>
<contributor.author>Chan, TM</contributor.author>
<contributor.author>Wong, RWS</contributor.author>
<contributor.author>Lee, KW</contributor.author>
<contributor.author>Mok, MY</contributor.author>
<contributor.author>Wong, SN</contributor.author>
<contributor.author>Avihingsanon, Y</contributor.author>
<contributor.author>Lee, TL</contributor.author>
<contributor.author>Ho, MHK</contributor.author>
<contributor.author>Lee, PPW</contributor.author>
<contributor.author>Wong, WHS</contributor.author>
<contributor.author>Lau, YL</contributor.author>
<date.accessioned>2010-09-17T10:22:02Z</date.accessioned>
<date.available>2010-09-17T10:22:02Z</date.available>
<date.issued>2009</date.issued>
<identifier.citation>Genes And Immunity, 2009, v. 10 n. 3, p. 219-226</identifier.citation>
<identifier.issn>1466-4879</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/91602</identifier.uri>
<description.abstract>In this study, we compared the association of several newly discovered susceptibility genes for systemic lupus erythematosus (SLE) between populations of European origin and two Asian populations. Using 910 SLE patients and 1440 healthy controls from Chinese living in Hong Kong, and 278 SLE patients and 383 controls in Thailand, we studied association of STAT4, BLK and PXK with the disease. Our data confirmed association of STAT4 (rs7574865, odds ratio (OR) =1.71, P=3.55 &#215; 10-23) and BLK (rs13277113, OR=0.77, P=1.34 &#215; 10-5) with SLE. It was showed that rs7574865 of STAT4 is also linked to hematologic disorders and potentially some other subphenotypes of the disease. More than one genetic variant in STAT4 were found to be associated with the disease independently in our populations (rs7601754, OR=0.59, P=1.39 &#215; 10-9, and P=0.00034 when controlling the effect of rs7574865). With the same set of samples, however, our study did not detect any significant disease association for PXK, a risk factor for populations of European origin (rs6445975, joint P=0.36, OR=1.06, 95% confidence interval: 0.93-1.21). Our study indicates that some of the susceptibility genes for this disease may be population specific.</description.abstract>
<language>eng</language>
<publisher>Nature Publishing Group. The Journal&apos;s web site is located at http://www.nature.com/gene</publisher>
<relation.ispartof>Genes and Immunity</relation.ispartof>
<subject.mesh>Adult</subject.mesh>
<subject.mesh>Female</subject.mesh>
<subject.mesh>Genetic Predisposition to Disease</subject.mesh>
<subject.mesh>Genotype</subject.mesh>
<subject.mesh>Hong Kong</subject.mesh>
<subject.mesh>Humans</subject.mesh>
<subject.mesh>Intracellular Signaling Peptides and Proteins - genetics</subject.mesh>
<subject.mesh>Linkage Disequilibrium</subject.mesh>
<subject.mesh>Lupus Erythematosus, Systemic - genetics</subject.mesh>
<subject.mesh>Male</subject.mesh>
<subject.mesh>Middle Aged</subject.mesh>
<subject.mesh>Nerve Tissue Proteins - genetics</subject.mesh>
<subject.mesh>Polymorphism, Single Nucleotide - genetics</subject.mesh>
<subject.mesh>Protein-Serine-Threonine Kinases - genetics</subject.mesh>
<subject.mesh>STAT4 Transcription Factor - genetics</subject.mesh>
<title>Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese</title>
<type>Article</type>
<description.nature>Link_to_subscribed_fulltext</description.nature>
<identifier.doi>10.1038/gene.2009.1</identifier.doi>
<identifier.pmid>19225526</identifier.pmid>
<identifier.scopus>eid_2-s2.0-67349113436</identifier.scopus>
<identifier.hkuros>155947</identifier.hkuros>
<identifier.hkuros>162918</identifier.hkuros>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-67349113436&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>10</identifier.volume>
<identifier.issue>3</identifier.issue>
<identifier.spage>219</identifier.spage>
<identifier.epage>226</identifier.epage>
<identifier.eissn>1476-5470</identifier.eissn>
<identifier.isi>WOS:000265961300003</identifier.isi>
<publisher.place>United Kingdom</publisher.place>
<identifier.citeulike>4089029</identifier.citeulike>
</item>
Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. Tuen Mun Hospital
  3. Chulalongkorn University
  4. Pamela Youde Nethersole Eastern Hospital