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Article: Association of F11 receptor gene polymorphisms with central obesity and blood pressure
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TitleAssociation of F11 receptor gene polymorphisms with central obesity and blood pressure
 
AuthorsOng, KL1
Leung, RYH1
Wong, LYF1
Cherny, SS1
Sham, PC1
Lam, TH1
Lam, KSL1
Cheung, BMY1 2
 
KeywordsCell adhesion molecules
F11 receptor
Gene polymorphism
Hypertension
Obesity
 
Issue Date2008
 
PublisherBlackwell Publishing Ltd
 
CitationJournal Of Internal Medicine, 2008, v. 263 n. 3, p. 322-332 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1365-2796.2007.01886.x
 
AbstractObjectives. F11 receptor, also known as junctional adhesion molecule-1, in the autonomic nervous system is implicated in the development of hypertension in spontaneous hypertensive rats. We investigated the association of single nucleotide polymorphisms (SNPs) in the F11 receptor gene (F11R) with hypertension and central obesity in Hong Kong Chinese. Methods. Seven tagging SNPs were identified in the HapMap database. Genotyping was performed using Sequenom MassArray in 263 hypertensive subjects and 393 normotensive controls, of whom 263 matched the cases in age and sex. Results. When subjects on anti-hypertensive medication were excluded, rs790056 and rs2774276 were associated with lower systolic blood pressure (TT:124.8 ± 18.3 mmHg vs. TC + CC: 120.2 ± 15.5 mmHg, P = 0.004 and CC: 124.7 ± 18.5 mmHg vs. CG+GG: 120.5 ± 15.1 mmHg, P = 0.007 respectively). Comparing 213 subjects with central obesity with 213 controls matched for sex and age, rs2481084 and rs3737787 were associated with lower odds of central obesity (odds ratio = 0.516, P = 0.002 and odds ratio = 0.540, P = 0.005 respectively). All these associations remained significant after correction for multiple testing. Analysis of statistically similar SNPs suggested that the causative variants for systolic blood pressure were located in F11R, whilst those for central obesity could be due to causative variants in the transcription factor 1 gene immediately upstream. Conclusions. F11 receptor plays a role in blood pressure regulation, not only in rats but also in man. The link between F11 receptor and central obesity merits further investigation. © 2007 Blackwell Publishing Ltd.
 
ISSN0954-6820
2013 Impact Factor: 5.785
 
DOIhttp://dx.doi.org/10.1111/j.1365-2796.2007.01886.x
 
ISI Accession Number IDWOS:000252930400010
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorOng, KL
 
dc.contributor.authorLeung, RYH
 
dc.contributor.authorWong, LYF
 
dc.contributor.authorCherny, SS
 
dc.contributor.authorSham, PC
 
dc.contributor.authorLam, TH
 
dc.contributor.authorLam, KSL
 
dc.contributor.authorCheung, BMY
 
dc.date.accessioned2010-09-17T10:21:35Z
 
dc.date.available2010-09-17T10:21:35Z
 
dc.date.issued2008
 
dc.description.abstractObjectives. F11 receptor, also known as junctional adhesion molecule-1, in the autonomic nervous system is implicated in the development of hypertension in spontaneous hypertensive rats. We investigated the association of single nucleotide polymorphisms (SNPs) in the F11 receptor gene (F11R) with hypertension and central obesity in Hong Kong Chinese. Methods. Seven tagging SNPs were identified in the HapMap database. Genotyping was performed using Sequenom MassArray in 263 hypertensive subjects and 393 normotensive controls, of whom 263 matched the cases in age and sex. Results. When subjects on anti-hypertensive medication were excluded, rs790056 and rs2774276 were associated with lower systolic blood pressure (TT:124.8 ± 18.3 mmHg vs. TC + CC: 120.2 ± 15.5 mmHg, P = 0.004 and CC: 124.7 ± 18.5 mmHg vs. CG+GG: 120.5 ± 15.1 mmHg, P = 0.007 respectively). Comparing 213 subjects with central obesity with 213 controls matched for sex and age, rs2481084 and rs3737787 were associated with lower odds of central obesity (odds ratio = 0.516, P = 0.002 and odds ratio = 0.540, P = 0.005 respectively). All these associations remained significant after correction for multiple testing. Analysis of statistically similar SNPs suggested that the causative variants for systolic blood pressure were located in F11R, whilst those for central obesity could be due to causative variants in the transcription factor 1 gene immediately upstream. Conclusions. F11 receptor plays a role in blood pressure regulation, not only in rats but also in man. The link between F11 receptor and central obesity merits further investigation. © 2007 Blackwell Publishing Ltd.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Internal Medicine, 2008, v. 263 n. 3, p. 322-332 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1365-2796.2007.01886.x
 
dc.identifier.citeulike2351260
 
dc.identifier.doihttp://dx.doi.org/10.1111/j.1365-2796.2007.01886.x
 
dc.identifier.eissn1365-2796
 
dc.identifier.epage332
 
dc.identifier.isiWOS:000252930400010
 
dc.identifier.issn0954-6820
2013 Impact Factor: 5.785
 
dc.identifier.issue3
 
dc.identifier.pmid18067551
 
dc.identifier.scopuseid_2-s2.0-38849155809
 
dc.identifier.spage322
 
dc.identifier.urihttp://hdl.handle.net/10722/91573
 
dc.identifier.volume263
 
dc.languageeng
 
dc.publisherBlackwell Publishing Ltd
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofJournal of Internal Medicine
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdult
 
dc.subject.meshAged
 
dc.subject.meshAsian Continental Ancestry Group - genetics
 
dc.subject.meshCase-Control Studies
 
dc.subject.meshCell Adhesion Molecules - genetics
 
dc.subject.meshCohort Studies
 
dc.subject.meshFemale
 
dc.subject.meshHong Kong
 
dc.subject.meshHumans
 
dc.subject.meshHypertension - ethnology - genetics
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshObesity - ethnology - genetics
 
dc.subject.meshPolymorphism, Single Nucleotide - genetics
 
dc.subject.meshReceptors, Cell Surface - genetics
 
dc.subjectCell adhesion molecules
 
dc.subjectF11 receptor
 
dc.subjectGene polymorphism
 
dc.subjectHypertension
 
dc.subjectObesity
 
dc.titleAssociation of F11 receptor gene polymorphisms with central obesity and blood pressure
 
dc.typeArticle
 
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<contributor.author>Cherny, SS</contributor.author>
<contributor.author>Sham, PC</contributor.author>
<contributor.author>Lam, TH</contributor.author>
<contributor.author>Lam, KSL</contributor.author>
<contributor.author>Cheung, BMY</contributor.author>
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<description.abstract>Objectives. F11 receptor, also known as junctional adhesion molecule-1, in the autonomic nervous system is implicated in the development of hypertension in spontaneous hypertensive rats. We investigated the association of single nucleotide polymorphisms (SNPs) in the F11 receptor gene (F11R) with hypertension and central obesity in Hong Kong Chinese. Methods. Seven tagging SNPs were identified in the HapMap database. Genotyping was performed using Sequenom MassArray in 263 hypertensive subjects and 393 normotensive controls, of whom 263 matched the cases in age and sex. Results. When subjects on anti-hypertensive medication were excluded, rs790056 and rs2774276 were associated with lower systolic blood pressure (TT:124.8 &#177; 18.3 mmHg vs. TC + CC: 120.2 &#177; 15.5 mmHg, P = 0.004 and CC: 124.7 &#177; 18.5 mmHg vs. CG+GG: 120.5 &#177; 15.1 mmHg, P = 0.007 respectively). Comparing 213 subjects with central obesity with 213 controls matched for sex and age, rs2481084 and rs3737787 were associated with lower odds of central obesity (odds ratio = 0.516, P = 0.002 and odds ratio = 0.540, P = 0.005 respectively). All these associations remained significant after correction for multiple testing. Analysis of statistically similar SNPs suggested that the causative variants for systolic blood pressure were located in F11R, whilst those for central obesity could be due to causative variants in the transcription factor 1 gene immediately upstream. Conclusions. F11 receptor plays a role in blood pressure regulation, not only in rats but also in man. The link between F11 receptor and central obesity merits further investigation. &#169; 2007 Blackwell Publishing Ltd.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong
  2. University of Birmingham