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Article: Elevated plasma level of soluble F11 receptor/junctional adhesion molecule-A(F11R/JAM-A) in hypertension

TitleElevated plasma level of soluble F11 receptor/junctional adhesion molecule-A(F11R/JAM-A) in hypertension
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2009
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajh/index.html
Citation
American Journal Of Hypertension, 2009, v. 22 n. 5, p. 500-505 How to Cite?
AbstractBackground: The F11 receptor (F11R, also known as junctional adhesion molecule A (JAM-A)) plays a role in the development of hypertension in rat. Genetic variants in the human F11R gene were demonstrated to influence systolic blood pressure. In the present study, we investigated the relationship between F11R and hypertension by examining the levels of a circulating soluble form of F11R (sF11R) in hypertensive patients.MethodsPlasma sF11R was measured by enzyme-linked immunosorbent assay in 152 hypertensive and 166 normotensive subjects in whom seven tagging single-nucleotide polymorphisms (SNPs) in the F11R gene had been genotyped.ResultsPlasma sF11R levels were significantly higher in hypertensive subjects than in normotensive subjects (median (interquartile) range): 162.8 (85.5-293.2) vs. 116.5 (74.1-194.8) pg/ml, P ≤ 0.004), which remained significantly higher after adjusting for age, sex, body mass index (BMI), and homeostasis model assessment of insulin resistance (HOMA-IR) (P ≤ 0.028). In stepwise multiple logistic regression, sF11R level (log-transformed) (P ≤ 0.040), triglycerides (log-transformed) (P ≤ 0.024), and HOMA-IR (log-transformed) (P < 0.001) were independently associated with hypertension. Plasma sF11R level correlated with systolic and diastolic blood pressures (r ≤ 0.15, P < 0.001, and r ≤ 0.13, P ≤ 0.024, respectively). In stepwise multiple linear regression, hypertension (P ≤ 0.013) and fibrinogen levels (P ≤ 0.027) were significant independent predictors of sF11R level. A seven-locus haplotype, present in 2.1% of the subjects, was associated with higher sF11R level (P ≤ 0.024).ConclusionsThese results further support a role of F11 receptor in the pathophysiology of human hypertension. © 2009 American Journal of Hypertension, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/91504
ISSN
2014 Impact Factor: 2.852
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grants Council7229/01M
7626/07M
Sun Chieh Yeh Heart Foundation
Funding Information:

The Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS2) was supported by a Hong Kong Research Grants Council Grant (#7229/01M) and the Sun Chieh Yeh Heart Foundation. The study of SNPs was supported by a Hong Kong Research Grants Council Grant (#7626/07M).

References

 

DC FieldValueLanguage
dc.contributor.authorOng, KLen_HK
dc.contributor.authorLeung, RYHen_HK
dc.contributor.authorBabinska, Aen_HK
dc.contributor.authorSalifu, MOen_HK
dc.contributor.authorEhrlich, YHen_HK
dc.contributor.authorKornecki, Een_HK
dc.contributor.authorWong, LYFen_HK
dc.contributor.authorTso, AWKen_HK
dc.contributor.authorCherny, SSen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorLam, KSLen_HK
dc.contributor.authorCheung, BMYen_HK
dc.date.accessioned2010-09-17T10:20:28Z-
dc.date.available2010-09-17T10:20:28Z-
dc.date.issued2009en_HK
dc.identifier.citationAmerican Journal Of Hypertension, 2009, v. 22 n. 5, p. 500-505en_HK
dc.identifier.issn0895-7061en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91504-
dc.description.abstractBackground: The F11 receptor (F11R, also known as junctional adhesion molecule A (JAM-A)) plays a role in the development of hypertension in rat. Genetic variants in the human F11R gene were demonstrated to influence systolic blood pressure. In the present study, we investigated the relationship between F11R and hypertension by examining the levels of a circulating soluble form of F11R (sF11R) in hypertensive patients.MethodsPlasma sF11R was measured by enzyme-linked immunosorbent assay in 152 hypertensive and 166 normotensive subjects in whom seven tagging single-nucleotide polymorphisms (SNPs) in the F11R gene had been genotyped.ResultsPlasma sF11R levels were significantly higher in hypertensive subjects than in normotensive subjects (median (interquartile) range): 162.8 (85.5-293.2) vs. 116.5 (74.1-194.8) pg/ml, P ≤ 0.004), which remained significantly higher after adjusting for age, sex, body mass index (BMI), and homeostasis model assessment of insulin resistance (HOMA-IR) (P ≤ 0.028). In stepwise multiple logistic regression, sF11R level (log-transformed) (P ≤ 0.040), triglycerides (log-transformed) (P ≤ 0.024), and HOMA-IR (log-transformed) (P < 0.001) were independently associated with hypertension. Plasma sF11R level correlated with systolic and diastolic blood pressures (r ≤ 0.15, P < 0.001, and r ≤ 0.13, P ≤ 0.024, respectively). In stepwise multiple linear regression, hypertension (P ≤ 0.013) and fibrinogen levels (P ≤ 0.027) were significant independent predictors of sF11R level. A seven-locus haplotype, present in 2.1% of the subjects, was associated with higher sF11R level (P ≤ 0.024).ConclusionsThese results further support a role of F11 receptor in the pathophysiology of human hypertension. © 2009 American Journal of Hypertension, Ltd.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajh/index.htmlen_HK
dc.relation.ispartofAmerican Journal of Hypertensionen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.subject.meshAgeden_HK
dc.subject.meshBlood Pressure - geneticsen_HK
dc.subject.meshCell Adhesion Molecules - blooden_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHypertension - blood - geneticsen_HK
dc.subject.meshInsulin Resistance - geneticsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPolymorphism, Single Nucleotideen_HK
dc.subject.meshReceptors, Cell Surface - blooden_HK
dc.subject.meshRegression Analysisen_HK
dc.titleElevated plasma level of soluble F11 receptor/junctional adhesion molecule-A(F11R/JAM-A) in hypertensionen_HK
dc.typeArticleen_HK
dc.identifier.emailTso, AWK: awk.tso@gmail.comen_HK
dc.identifier.emailCherny, SS: cherny@hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hken_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.emailCheung, BMY: mycheung@hku.hken_HK
dc.identifier.authorityTso, AWK=rp00535en_HK
dc.identifier.authorityCherny, SS=rp00232en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/ajh.2009.23en_HK
dc.identifier.pmid19214165en_HK
dc.identifier.scopuseid_2-s2.0-67349151136en_HK
dc.identifier.hkuros155399-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67349151136&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume22en_HK
dc.identifier.issue5en_HK
dc.identifier.spage500en_HK
dc.identifier.epage505en_HK
dc.identifier.isiWOS:000265335100011-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridOng, KL=8340854000en_HK
dc.identifier.scopusauthoridLeung, RYH=7101876102en_HK
dc.identifier.scopusauthoridBabinska, A=36895783800en_HK
dc.identifier.scopusauthoridSalifu, MO=6602696129en_HK
dc.identifier.scopusauthoridEhrlich, YH=7006966496en_HK
dc.identifier.scopusauthoridKornecki, E=7003962788en_HK
dc.identifier.scopusauthoridWong, LYF=24476809800en_HK
dc.identifier.scopusauthoridTso, AWK=6701371436en_HK
dc.identifier.scopusauthoridCherny, SS=7004670001en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK

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