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Article: Elevated plasma level of soluble F11 receptor/junctional adhesion molecule-A(F11R/JAM-A) in hypertension
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TitleElevated plasma level of soluble F11 receptor/junctional adhesion molecule-A(F11R/JAM-A) in hypertension
 
AuthorsOng, KL1
Leung, RYH1
Babinska, A4
Salifu, MO4
Ehrlich, YH2
Kornecki, E4
Wong, LYF1
Tso, AWK1
Cherny, SS1
Sham, PC1
Lam, TH1
Lam, KSL1
Cheung, BMY3
 
KeywordsChemicals And Cas Registry Numbers
 
Issue Date2009
 
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajh/index.html
 
CitationAmerican Journal Of Hypertension, 2009, v. 22 n. 5, p. 500-505 [How to Cite?]
DOI: http://dx.doi.org/10.1038/ajh.2009.23
 
AbstractBackground: The F11 receptor (F11R, also known as junctional adhesion molecule A (JAM-A)) plays a role in the development of hypertension in rat. Genetic variants in the human F11R gene were demonstrated to influence systolic blood pressure. In the present study, we investigated the relationship between F11R and hypertension by examining the levels of a circulating soluble form of F11R (sF11R) in hypertensive patients.MethodsPlasma sF11R was measured by enzyme-linked immunosorbent assay in 152 hypertensive and 166 normotensive subjects in whom seven tagging single-nucleotide polymorphisms (SNPs) in the F11R gene had been genotyped.ResultsPlasma sF11R levels were significantly higher in hypertensive subjects than in normotensive subjects (median (interquartile) range): 162.8 (85.5-293.2) vs. 116.5 (74.1-194.8) pg/ml, P ≤ 0.004), which remained significantly higher after adjusting for age, sex, body mass index (BMI), and homeostasis model assessment of insulin resistance (HOMA-IR) (P ≤ 0.028). In stepwise multiple logistic regression, sF11R level (log-transformed) (P ≤ 0.040), triglycerides (log-transformed) (P ≤ 0.024), and HOMA-IR (log-transformed) (P < 0.001) were independently associated with hypertension. Plasma sF11R level correlated with systolic and diastolic blood pressures (r ≤ 0.15, P < 0.001, and r ≤ 0.13, P ≤ 0.024, respectively). In stepwise multiple linear regression, hypertension (P ≤ 0.013) and fibrinogen levels (P ≤ 0.027) were significant independent predictors of sF11R level. A seven-locus haplotype, present in 2.1% of the subjects, was associated with higher sF11R level (P ≤ 0.024).ConclusionsThese results further support a role of F11 receptor in the pathophysiology of human hypertension. © 2009 American Journal of Hypertension, Ltd.
 
ISSN0895-7061
2012 Impact Factor: 3.665
2012 SCImago Journal Rankings: 1.268
 
DOIhttp://dx.doi.org/10.1038/ajh.2009.23
 
ISI Accession Number IDWOS:000265335100011
Funding AgencyGrant Number
Hong Kong Research Grants Council7229/01M
7626/07M
Sun Chieh Yeh Heart Foundation
Funding Information:

The Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS2) was supported by a Hong Kong Research Grants Council Grant (#7229/01M) and the Sun Chieh Yeh Heart Foundation. The study of SNPs was supported by a Hong Kong Research Grants Council Grant (#7626/07M).

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorOng, KL
 
dc.contributor.authorLeung, RYH
 
dc.contributor.authorBabinska, A
 
dc.contributor.authorSalifu, MO
 
dc.contributor.authorEhrlich, YH
 
dc.contributor.authorKornecki, E
 
dc.contributor.authorWong, LYF
 
dc.contributor.authorTso, AWK
 
dc.contributor.authorCherny, SS
 
dc.contributor.authorSham, PC
 
dc.contributor.authorLam, TH
 
dc.contributor.authorLam, KSL
 
dc.contributor.authorCheung, BMY
 
dc.date.accessioned2010-09-17T10:20:28Z
 
dc.date.available2010-09-17T10:20:28Z
 
dc.date.issued2009
 
dc.description.abstractBackground: The F11 receptor (F11R, also known as junctional adhesion molecule A (JAM-A)) plays a role in the development of hypertension in rat. Genetic variants in the human F11R gene were demonstrated to influence systolic blood pressure. In the present study, we investigated the relationship between F11R and hypertension by examining the levels of a circulating soluble form of F11R (sF11R) in hypertensive patients.MethodsPlasma sF11R was measured by enzyme-linked immunosorbent assay in 152 hypertensive and 166 normotensive subjects in whom seven tagging single-nucleotide polymorphisms (SNPs) in the F11R gene had been genotyped.ResultsPlasma sF11R levels were significantly higher in hypertensive subjects than in normotensive subjects (median (interquartile) range): 162.8 (85.5-293.2) vs. 116.5 (74.1-194.8) pg/ml, P ≤ 0.004), which remained significantly higher after adjusting for age, sex, body mass index (BMI), and homeostasis model assessment of insulin resistance (HOMA-IR) (P ≤ 0.028). In stepwise multiple logistic regression, sF11R level (log-transformed) (P ≤ 0.040), triglycerides (log-transformed) (P ≤ 0.024), and HOMA-IR (log-transformed) (P < 0.001) were independently associated with hypertension. Plasma sF11R level correlated with systolic and diastolic blood pressures (r ≤ 0.15, P < 0.001, and r ≤ 0.13, P ≤ 0.024, respectively). In stepwise multiple linear regression, hypertension (P ≤ 0.013) and fibrinogen levels (P ≤ 0.027) were significant independent predictors of sF11R level. A seven-locus haplotype, present in 2.1% of the subjects, was associated with higher sF11R level (P ≤ 0.024).ConclusionsThese results further support a role of F11 receptor in the pathophysiology of human hypertension. © 2009 American Journal of Hypertension, Ltd.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationAmerican Journal Of Hypertension, 2009, v. 22 n. 5, p. 500-505 [How to Cite?]
DOI: http://dx.doi.org/10.1038/ajh.2009.23
 
dc.identifier.doihttp://dx.doi.org/10.1038/ajh.2009.23
 
dc.identifier.epage505
 
dc.identifier.hkuros155399
 
dc.identifier.isiWOS:000265335100011
Funding AgencyGrant Number
Hong Kong Research Grants Council7229/01M
7626/07M
Sun Chieh Yeh Heart Foundation
Funding Information:

The Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS2) was supported by a Hong Kong Research Grants Council Grant (#7229/01M) and the Sun Chieh Yeh Heart Foundation. The study of SNPs was supported by a Hong Kong Research Grants Council Grant (#7626/07M).

 
dc.identifier.issn0895-7061
2012 Impact Factor: 3.665
2012 SCImago Journal Rankings: 1.268
 
dc.identifier.issue5
 
dc.identifier.pmid19214165
 
dc.identifier.scopuseid_2-s2.0-67349151136
 
dc.identifier.spage500
 
dc.identifier.urihttp://hdl.handle.net/10722/91504
 
dc.identifier.volume22
 
dc.languageeng
 
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajh/index.html
 
dc.publisher.placeUnited States
 
dc.relation.ispartofAmerican Journal of Hypertension
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAged
 
dc.subject.meshBlood Pressure - genetics
 
dc.subject.meshCell Adhesion Molecules - blood
 
dc.subject.meshFemale
 
dc.subject.meshHumans
 
dc.subject.meshHypertension - blood - genetics
 
dc.subject.meshInsulin Resistance - genetics
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshPolymorphism, Single Nucleotide
 
dc.subject.meshReceptors, Cell Surface - blood
 
dc.subject.meshRegression Analysis
 
dc.subjectChemicals And Cas Registry Numbers
 
dc.titleElevated plasma level of soluble F11 receptor/junctional adhesion molecule-A(F11R/JAM-A) in hypertension
 
dc.typeArticle
 
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<contributor.author>Ehrlich, YH</contributor.author>
<contributor.author>Kornecki, E</contributor.author>
<contributor.author>Wong, LYF</contributor.author>
<contributor.author>Tso, AWK</contributor.author>
<contributor.author>Cherny, SS</contributor.author>
<contributor.author>Sham, PC</contributor.author>
<contributor.author>Lam, TH</contributor.author>
<contributor.author>Lam, KSL</contributor.author>
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<description.abstract>Background: The F11 receptor (F11R, also known as junctional adhesion molecule A (JAM-A)) plays a role in the development of hypertension in rat. Genetic variants in the human F11R gene were demonstrated to influence systolic blood pressure. In the present study, we investigated the relationship between F11R and hypertension by examining the levels of a circulating soluble form of F11R (sF11R) in hypertensive patients.MethodsPlasma sF11R was measured by enzyme-linked immunosorbent assay in 152 hypertensive and 166 normotensive subjects in whom seven tagging single-nucleotide polymorphisms (SNPs) in the F11R gene had been genotyped.ResultsPlasma sF11R levels were significantly higher in hypertensive subjects than in normotensive subjects (median (interquartile) range): 162.8 (85.5-293.2) vs. 116.5 (74.1-194.8) pg/ml, P &#8804; 0.004), which remained significantly higher after adjusting for age, sex, body mass index (BMI), and homeostasis model assessment of insulin resistance (HOMA-IR) (P &#8804; 0.028). In stepwise multiple logistic regression, sF11R level (log-transformed) (P &#8804; 0.040), triglycerides (log-transformed) (P &#8804; 0.024), and HOMA-IR (log-transformed) (P &lt; 0.001) were independently associated with hypertension. Plasma sF11R level correlated with systolic and diastolic blood pressures (r &#8804; 0.15, P &lt; 0.001, and r &#8804; 0.13, P &#8804; 0.024, respectively). In stepwise multiple linear regression, hypertension (P &#8804; 0.013) and fibrinogen levels (P &#8804; 0.027) were significant independent predictors of sF11R level. A seven-locus haplotype, present in 2.1% of the subjects, was associated with higher sF11R level (P &#8804; 0.024).ConclusionsThese results further support a role of F11 receptor in the pathophysiology of human hypertension. &#169; 2009 American Journal of Hypertension, Ltd.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong
  2. City University of New York
  3. University of Birmingham
  4. SUNY Downstate Medical Center