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Article: A genetic variant in the gene encoding fibrinogen beta chain predicted development of hypertension in Chinese men

TitleA genetic variant in the gene encoding fibrinogen beta chain predicted development of hypertension in Chinese men
Authors
KeywordsFibrinogen
Hypertension
Single nucleotide polymorphisms
Issue Date2010
PublisherSchattauer GmbH. The Journal's web site is located at http://www.thrombosis-online.com
Citation
Thrombosis And Haemostasis, 2010, v. 103 n. 4, p. 728-735 How to Cite?
AbstractFibrinogen, a major determinant of blood viscosity, is an acute phase protein associated with cardiovascular disease. We studied the association of hypertension with single nucleotide polymorphisms (SNPs) in the gene encoding the fibrinogen β chain (FGB). Three tagging SNPs (rs1025154, rs4220 and rs1044291) were selected from the HapMap database on Han Chinese. Genotypes were determined in 1,294 unrelated subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study cohort. There were 199 hypertensive subjects at baseline. Among 1,095 subjects normotensive at baseline, 178 developed hypertension during a median follow-up period of 6.4 years. Among the three tagging SNPs, rs4220 showed significant association with hypertension at both baseline (odds ratio [OR]=1.49, p=0.004) and at follow-up (OR=1.32, p=0.013). The minor A allele of this SNP was associated with higher plasma fibrinogen level (β=0.144, p<0.001 at baseline and β=0.130, p<0.001 at follow-up). Among subjects normotensive at baseline, this SNP was also associated with the development of hypertension in men (OR=1.52, p=0.022), but not in women. The SNP rs4220 in FGB, which leads to the substitution of arginine by lysine at position 448, is independently associated with plasma fibrinogen level and hypertension in Hong Kong Chinese. This suggests a possible causal role of fibrinogen in hypertension development, especially in men. © Schattauer 2010.
Persistent Identifierhttp://hdl.handle.net/10722/91478
ISSN
2015 Impact Factor: 5.255
2015 SCImago Journal Rankings: 2.089
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grant CouncilHKU7229/01M
HKU7626/07M
Sun Chieh Yeh Heart Foundation
National Natural Science Foundation of China/Research Grants Council of Hong Kong Joint Research Scheme30518001/CO301070202
HKU720/05
Funding Information:

The Hong Kong Cardiovascular Risk Factor Prevalence Study-2 was funded by Hong Kong Research Grant Council grants (HKU7229/01M and HKU7626/07M), and the Sun Chieh Yeh Heart Foundation. The genotyping of SNPs in the FGB gene was supported by a grant from the National Natural Science Foundation of China/Research Grants Council of Hong Kong Joint Research Scheme (30518001/CO301070202 and HKU720/05).

References

 

DC FieldValueLanguage
dc.contributor.authorOng, KLen_HK
dc.contributor.authorTso, AWKen_HK
dc.contributor.authorCherny, SSen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorLam, KSLen_HK
dc.contributor.authorJiang, CQen_HK
dc.contributor.authorThomas, GNen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorCheung, BMYen_HK
dc.date.accessioned2010-09-17T10:20:04Z-
dc.date.available2010-09-17T10:20:04Z-
dc.date.issued2010en_HK
dc.identifier.citationThrombosis And Haemostasis, 2010, v. 103 n. 4, p. 728-735en_HK
dc.identifier.issn0340-6245en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91478-
dc.description.abstractFibrinogen, a major determinant of blood viscosity, is an acute phase protein associated with cardiovascular disease. We studied the association of hypertension with single nucleotide polymorphisms (SNPs) in the gene encoding the fibrinogen β chain (FGB). Three tagging SNPs (rs1025154, rs4220 and rs1044291) were selected from the HapMap database on Han Chinese. Genotypes were determined in 1,294 unrelated subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study cohort. There were 199 hypertensive subjects at baseline. Among 1,095 subjects normotensive at baseline, 178 developed hypertension during a median follow-up period of 6.4 years. Among the three tagging SNPs, rs4220 showed significant association with hypertension at both baseline (odds ratio [OR]=1.49, p=0.004) and at follow-up (OR=1.32, p=0.013). The minor A allele of this SNP was associated with higher plasma fibrinogen level (β=0.144, p<0.001 at baseline and β=0.130, p<0.001 at follow-up). Among subjects normotensive at baseline, this SNP was also associated with the development of hypertension in men (OR=1.52, p=0.022), but not in women. The SNP rs4220 in FGB, which leads to the substitution of arginine by lysine at position 448, is independently associated with plasma fibrinogen level and hypertension in Hong Kong Chinese. This suggests a possible causal role of fibrinogen in hypertension development, especially in men. © Schattauer 2010.en_HK
dc.languageengen_HK
dc.publisherSchattauer GmbH. The Journal's web site is located at http://www.thrombosis-online.comen_HK
dc.relation.ispartofThrombosis and Haemostasisen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectFibrinogenen_HK
dc.subjectHypertensionen_HK
dc.subjectSingle nucleotide polymorphismsen_HK
dc.subject.meshAmino Acid Substitution-
dc.subject.meshAsian Continental Ancestry Group - genetics-
dc.subject.meshFibrinogen - genetics - metabolism-
dc.subject.meshHypertension - blood - ethnology - genetics - physiopathology-
dc.subject.meshPolymorphism, Single Nucleotide-
dc.titleA genetic variant in the gene encoding fibrinogen beta chain predicted development of hypertension in Chinese menen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0340-6245&volume=103&issue=4&spage=728&epage=735&date=2010&atitle=A+genetic+variant+in+the+gene+encoding+fibrinogen+beta+chain+predicted+development+of+hypertension+in+Chinese+men-
dc.identifier.emailTso, AWK: awk.tso@gmail.comen_HK
dc.identifier.emailCherny, SS: cherny@hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hken_HK
dc.identifier.emailCheung, BMY: mycheung@hku.hken_HK
dc.identifier.authorityTso, AWK=rp00535en_HK
dc.identifier.authorityCherny, SS=rp00232en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1160/TH09-10-0692en_HK
dc.identifier.pmid20135074-
dc.identifier.scopuseid_2-s2.0-77952061965en_HK
dc.identifier.hkuros173147-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77952061965&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume103en_HK
dc.identifier.issue4en_HK
dc.identifier.spage728en_HK
dc.identifier.epage735en_HK
dc.identifier.isiWOS:000277031700009-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridOng, KL=8340854000en_HK
dc.identifier.scopusauthoridTso, AWK=6701371436en_HK
dc.identifier.scopusauthoridCherny, SS=7004670001en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK
dc.identifier.scopusauthoridJiang, CQ=10639500500en_HK
dc.identifier.scopusauthoridThomas, GN=35465269900en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK

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