File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Serum adipocyte-fatty acid binding protein level is elevated in severe OSA and correlates with insulin resistance
  • Basic View
  • Metadata View
  • XML View
TitleSerum adipocyte-fatty acid binding protein level is elevated in severe OSA and correlates with insulin resistance
 
AuthorsLam, DCL1
Xu, A1
Lam, KSL1
Lam, B1
Lam, JCM1
Lui, MMS1
Ip, MSM1
 
KeywordsChemicals And Cas Registry Numbers
 
Issue Date2009
 
PublisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com
 
CitationEuropean Respiratory Journal, 2009, v. 33 n. 2, p. 346-351 [How to Cite?]
DOI: http://dx.doi.org/10.1183/09031936.50075408
 
AbstractObstructive sleep apnoea (OSA) is associated with insulin resistance and metabolic syndrome. There is evidence that adipocyte-fatty acid binding protein (A-FABP) may be involved in the development of cardiometabolic dysfunction. The present authors hypothesise that A-FABP is upregulated in OSA. A total of 124 males without hypertension, diabetes mellitus, hyperlipidaemia or cardiovascular disease were recruited and underwent polysomnography. Serum A-FABP levels showed significant positive correlations with duration of oxygen desaturation and minimal oxygen saturation, fasting insulin and insulin resistance index by homeostasis model assessment. When subjects were divided into tertiles according to apnoea/hypopnoea index (AHI), serum A-FABP levels were significantly higher in the group with AHI ≥34.4 eventsh-1 than the groups with AHI 13.2-34.4 eventsh-1 or with AHI <13.2 eventsh-1. Serum A-FABP levels were significantly higher in the AHI ≥34.4 group than obesity-matched subjects with AHI <34.4 eventsh-1. Serum adipocyte-fatty acid binding protein levels correlated with obstructive sleep apnoea and insulin resistance, independently of obesity, and were significantly higher in severe obstructive sleep apnoea. Adipocyte-fatty acid binding protein may play a role in obstructive sleep apnoea and metabolic dysfunction. Copyright © ERS Journals Ltd 2009.
 
ISSN0903-1936
2013 Impact Factor: 7.125
 
DOIhttp://dx.doi.org/10.1183/09031936.50075408
 
ISI Accession Number IDWOS:000263709300018
Funding AgencyGrant Number
Research Grants Council (RGC) Earmarked Competitive Grant award7667/07M
RGC Central AllocationHKU 2/07C
Lee Wing Tat Cardiorespiratory Research Fund
Funding Information:

This study was jointly supported by the Research Grants Council (RGC) Earmarked Competitive Grant award 7667/07M, the RGC Central Allocation Grant (HKU 2/07C) and the Lee Wing Tat Cardiorespiratory Research Fund.

 
ReferencesReferences in Scopus
 
GrantsVascular dysfunction in obesity and diabetes: from risk prediction to therapeutic intervention
 
DC FieldValue
dc.contributor.authorLam, DCL
 
dc.contributor.authorXu, A
 
dc.contributor.authorLam, KSL
 
dc.contributor.authorLam, B
 
dc.contributor.authorLam, JCM
 
dc.contributor.authorLui, MMS
 
dc.contributor.authorIp, MSM
 
dc.date.accessioned2010-09-17T10:20:03Z
 
dc.date.available2010-09-17T10:20:03Z
 
dc.date.issued2009
 
dc.description.abstractObstructive sleep apnoea (OSA) is associated with insulin resistance and metabolic syndrome. There is evidence that adipocyte-fatty acid binding protein (A-FABP) may be involved in the development of cardiometabolic dysfunction. The present authors hypothesise that A-FABP is upregulated in OSA. A total of 124 males without hypertension, diabetes mellitus, hyperlipidaemia or cardiovascular disease were recruited and underwent polysomnography. Serum A-FABP levels showed significant positive correlations with duration of oxygen desaturation and minimal oxygen saturation, fasting insulin and insulin resistance index by homeostasis model assessment. When subjects were divided into tertiles according to apnoea/hypopnoea index (AHI), serum A-FABP levels were significantly higher in the group with AHI ≥34.4 eventsh-1 than the groups with AHI 13.2-34.4 eventsh-1 or with AHI <13.2 eventsh-1. Serum A-FABP levels were significantly higher in the AHI ≥34.4 group than obesity-matched subjects with AHI <34.4 eventsh-1. Serum adipocyte-fatty acid binding protein levels correlated with obstructive sleep apnoea and insulin resistance, independently of obesity, and were significantly higher in severe obstructive sleep apnoea. Adipocyte-fatty acid binding protein may play a role in obstructive sleep apnoea and metabolic dysfunction. Copyright © ERS Journals Ltd 2009.
 
dc.description.natureLink_to_OA_fulltext
 
dc.identifier.citationEuropean Respiratory Journal, 2009, v. 33 n. 2, p. 346-351 [How to Cite?]
DOI: http://dx.doi.org/10.1183/09031936.50075408
 
dc.identifier.doihttp://dx.doi.org/10.1183/09031936.50075408
 
dc.identifier.eissn1399-3003
 
dc.identifier.epage351
 
dc.identifier.hkuros155048
 
dc.identifier.isiWOS:000263709300018
Funding AgencyGrant Number
Research Grants Council (RGC) Earmarked Competitive Grant award7667/07M
RGC Central AllocationHKU 2/07C
Lee Wing Tat Cardiorespiratory Research Fund
Funding Information:

This study was jointly supported by the Research Grants Council (RGC) Earmarked Competitive Grant award 7667/07M, the RGC Central Allocation Grant (HKU 2/07C) and the Lee Wing Tat Cardiorespiratory Research Fund.

 
dc.identifier.issn0903-1936
2013 Impact Factor: 7.125
 
dc.identifier.issue2
 
dc.identifier.pmid19181913
 
dc.identifier.scopuseid_2-s2.0-59649105053
 
dc.identifier.spage346
 
dc.identifier.urihttp://hdl.handle.net/10722/91477
 
dc.identifier.volume33
 
dc.languageeng
 
dc.publisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com
 
dc.publisher.placeSwitzerland
 
dc.relation.ispartofEuropean Respiratory Journal
 
dc.relation.projectVascular dysfunction in obesity and diabetes: from risk prediction to therapeutic intervention
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdult
 
dc.subject.meshAnthropometry - methods
 
dc.subject.meshBody Mass Index
 
dc.subject.meshCohort Studies
 
dc.subject.meshFatty Acid-Binding Proteins - blood
 
dc.subject.meshGene Expression Regulation
 
dc.subject.meshHumans
 
dc.subject.meshInsulin - metabolism
 
dc.subject.meshInsulin Resistance
 
dc.subject.meshMale
 
dc.subject.meshMetabolic Syndrome X - metabolism
 
dc.subject.meshMiddle Aged
 
dc.subject.meshOxygen - metabolism
 
dc.subject.meshPolysomnography - methods
 
dc.subject.meshSleep Apnea, Obstructive - blood - diagnosis
 
dc.subjectChemicals And Cas Registry Numbers
 
dc.titleSerum adipocyte-fatty acid binding protein level is elevated in severe OSA and correlates with insulin resistance
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Lam, DCL</contributor.author>
<contributor.author>Xu, A</contributor.author>
<contributor.author>Lam, KSL</contributor.author>
<contributor.author>Lam, B</contributor.author>
<contributor.author>Lam, JCM</contributor.author>
<contributor.author>Lui, MMS</contributor.author>
<contributor.author>Ip, MSM</contributor.author>
<date.accessioned>2010-09-17T10:20:03Z</date.accessioned>
<date.available>2010-09-17T10:20:03Z</date.available>
<date.issued>2009</date.issued>
<identifier.citation>European Respiratory Journal, 2009, v. 33 n. 2, p. 346-351</identifier.citation>
<identifier.issn>0903-1936</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/91477</identifier.uri>
<description.abstract>Obstructive sleep apnoea (OSA) is associated with insulin resistance and metabolic syndrome. There is evidence that adipocyte-fatty acid binding protein (A-FABP) may be involved in the development of cardiometabolic dysfunction. The present authors hypothesise that A-FABP is upregulated in OSA. A total of 124 males without hypertension, diabetes mellitus, hyperlipidaemia or cardiovascular disease were recruited and underwent polysomnography. Serum A-FABP levels showed significant positive correlations with duration of oxygen desaturation and minimal oxygen saturation, fasting insulin and insulin resistance index by homeostasis model assessment. When subjects were divided into tertiles according to apnoea/hypopnoea index (AHI), serum A-FABP levels were significantly higher in the group with AHI &#8805;34.4 eventsh-1 than the groups with AHI 13.2-34.4 eventsh-1 or with AHI &lt;13.2 eventsh-1. Serum A-FABP levels were significantly higher in the AHI &#8805;34.4 group than obesity-matched subjects with AHI &lt;34.4 eventsh-1. Serum adipocyte-fatty acid binding protein levels correlated with obstructive sleep apnoea and insulin resistance, independently of obesity, and were significantly higher in severe obstructive sleep apnoea. Adipocyte-fatty acid binding protein may play a role in obstructive sleep apnoea and metabolic dysfunction. Copyright &#169; ERS Journals Ltd 2009.</description.abstract>
<language>eng</language>
<publisher>European Respiratory Society. The Journal&apos;s web site is located at http://erj.ersjournals.com</publisher>
<relation.ispartof>European Respiratory Journal</relation.ispartof>
<subject>Chemicals And Cas Registry Numbers</subject>
<subject.mesh>Adult</subject.mesh>
<subject.mesh>Anthropometry - methods</subject.mesh>
<subject.mesh>Body Mass Index</subject.mesh>
<subject.mesh>Cohort Studies</subject.mesh>
<subject.mesh>Fatty Acid-Binding Proteins - blood</subject.mesh>
<subject.mesh>Gene Expression Regulation</subject.mesh>
<subject.mesh>Humans</subject.mesh>
<subject.mesh>Insulin - metabolism</subject.mesh>
<subject.mesh>Insulin Resistance</subject.mesh>
<subject.mesh>Male</subject.mesh>
<subject.mesh>Metabolic Syndrome X - metabolism</subject.mesh>
<subject.mesh>Middle Aged</subject.mesh>
<subject.mesh>Oxygen - metabolism</subject.mesh>
<subject.mesh>Polysomnography - methods</subject.mesh>
<subject.mesh>Sleep Apnea, Obstructive - blood - diagnosis</subject.mesh>
<title>Serum adipocyte-fatty acid binding protein level is elevated in severe OSA and correlates with insulin resistance</title>
<type>Article</type>
<description.nature>Link_to_OA_fulltext</description.nature>
<identifier.doi>10.1183/09031936.50075408</identifier.doi>
<identifier.pmid>19181913</identifier.pmid>
<identifier.scopus>eid_2-s2.0-59649105053</identifier.scopus>
<identifier.hkuros>155048</identifier.hkuros>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-59649105053&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>33</identifier.volume>
<identifier.issue>2</identifier.issue>
<identifier.spage>346</identifier.spage>
<identifier.epage>351</identifier.epage>
<identifier.eissn>1399-3003</identifier.eissn>
<identifier.isi>WOS:000263709300018</identifier.isi>
<publisher.place>Switzerland</publisher.place>
<relation.project>Vascular dysfunction in obesity and diabetes: from risk prediction to therapeutic intervention</relation.project>
<bitstream.url>http://hub.hku.hk/bitstream/10722/91477/1/re01.htm</bitstream.url>
</item>
Author Affiliations
  1. The University of Hong Kong