Article: Serum adipocyte-fatty acid binding protein level is elevated in severe OSA and correlates with insulin resistance

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TitleSerum adipocyte-fatty acid binding protein level is elevated in severe OSA and correlates with insulin resistance
AuthorsLam, DCL1
Xu, A1
Lam, KSL1
Lam, B1
Lam, JCM1
Lui, MMS1
Ip, MSM1
KeywordsChemicals And Cas Registry Numbers
Issue Date2009
PublisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com
CitationEuropean Respiratory Journal, 2009, v. 33 n. 2, p. 346-351 [How to Cite?]
DOI: http://dx.doi.org/10.1183/09031936.50075408
AbstractObstructive sleep apnoea (OSA) is associated with insulin resistance and metabolic syndrome. There is evidence that adipocyte-fatty acid binding protein (A-FABP) may be involved in the development of cardiometabolic dysfunction. The present authors hypothesise that A-FABP is upregulated in OSA. A total of 124 males without hypertension, diabetes mellitus, hyperlipidaemia or cardiovascular disease were recruited and underwent polysomnography. Serum A-FABP levels showed significant positive correlations with duration of oxygen desaturation and minimal oxygen saturation, fasting insulin and insulin resistance index by homeostasis model assessment. When subjects were divided into tertiles according to apnoea/hypopnoea index (AHI), serum A-FABP levels were significantly higher in the group with AHI ≥34.4 eventsh-1 than the groups with AHI 13.2-34.4 eventsh-1 or with AHI <13.2 eventsh-1. Serum A-FABP levels were significantly higher in the AHI ≥34.4 group than obesity-matched subjects with AHI <34.4 eventsh-1. Serum adipocyte-fatty acid binding protein levels correlated with obstructive sleep apnoea and insulin resistance, independently of obesity, and were significantly higher in severe obstructive sleep apnoea. Adipocyte-fatty acid binding protein may play a role in obstructive sleep apnoea and metabolic dysfunction. Copyright © ERS Journals Ltd 2009.
ISSN0903-1936
2011 Impact Factor: 5.895
2011 SCImago Journal Rankings: 0.466
DOIhttp://dx.doi.org/10.1183/09031936.50075408
ISI Accession Number IDWOS:000263709300018
Funding AgencyGrant Number
Research Grants Council (RGC) Earmarked Competitive Grant award7667/07M
RGC Central AllocationHKU 2/07C
Lee Wing Tat Cardiorespiratory Research Fund
Funding Information:

This study was jointly supported by the Research Grants Council (RGC) Earmarked Competitive Grant award 7667/07M, the RGC Central Allocation Grant (HKU 2/07C) and the Lee Wing Tat Cardiorespiratory Research Fund.

ReferencesReferences in Scopus
GrantsVascular dysfunction in obesity and diabetes: from risk prediction to therapeutic intervention
DC Field
Value
dc.contributor.authorLam, DCL
dc.contributor.authorXu, A
dc.contributor.authorLam, KSL
dc.contributor.authorLam, B
dc.contributor.authorLam, JCM
dc.contributor.authorLui, MMS
dc.contributor.authorIp, MSM
dc.date.accessioned2010-09-17T10:20:03Z
dc.date.available2010-09-17T10:20:03Z
dc.date.issued2009
dc.description.abstractObstructive sleep apnoea (OSA) is associated with insulin resistance and metabolic syndrome. There is evidence that adipocyte-fatty acid binding protein (A-FABP) may be involved in the development of cardiometabolic dysfunction. The present authors hypothesise that A-FABP is upregulated in OSA. A total of 124 males without hypertension, diabetes mellitus, hyperlipidaemia or cardiovascular disease were recruited and underwent polysomnography. Serum A-FABP levels showed significant positive correlations with duration of oxygen desaturation and minimal oxygen saturation, fasting insulin and insulin resistance index by homeostasis model assessment. When subjects were divided into tertiles according to apnoea/hypopnoea index (AHI), serum A-FABP levels were significantly higher in the group with AHI ≥34.4 eventsh-1 than the groups with AHI 13.2-34.4 eventsh-1 or with AHI <13.2 eventsh-1. Serum A-FABP levels were significantly higher in the AHI ≥34.4 group than obesity-matched subjects with AHI <34.4 eventsh-1. Serum adipocyte-fatty acid binding protein levels correlated with obstructive sleep apnoea and insulin resistance, independently of obesity, and were significantly higher in severe obstructive sleep apnoea. Adipocyte-fatty acid binding protein may play a role in obstructive sleep apnoea and metabolic dysfunction. Copyright © ERS Journals Ltd 2009.
dc.description.grantVascular dysfunction in obesity and diabetes: from risk prediction to therapeutic intervention
dc.description.grantcode97656
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationEuropean Respiratory Journal, 2009, v. 33 n. 2, p. 346-351 [How to Cite?]
DOI: http://dx.doi.org/10.1183/09031936.50075408
dc.identifier.doihttp://dx.doi.org/10.1183/09031936.50075408
dc.identifier.eissn1399-3003
dc.identifier.epage351
dc.identifier.isiWOS:000263709300018
Funding AgencyGrant Number
Research Grants Council (RGC) Earmarked Competitive Grant award7667/07M
RGC Central AllocationHKU 2/07C
Lee Wing Tat Cardiorespiratory Research Fund
Funding Information:

This study was jointly supported by the Research Grants Council (RGC) Earmarked Competitive Grant award 7667/07M, the RGC Central Allocation Grant (HKU 2/07C) and the Lee Wing Tat Cardiorespiratory Research Fund.

dc.identifier.issn0903-1936
2011 Impact Factor: 5.895
2011 SCImago Journal Rankings: 0.466
dc.identifier.issue2
dc.identifier.pmid19181913
dc.identifier.scopuseid_2-s2.0-59649105053
dc.identifier.spage346
dc.identifier.urihttp://hdl.handle.net/10722/91477
dc.identifier.volume33
dc.languageeng
dc.publisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com
dc.publisher.placeSwitzerland
dc.relation.ispartofEuropean Respiratory Journal
dc.relation.referencesReferences in Scopus
dc.subject.meshAdult
dc.subject.meshAnthropometry - methods
dc.subject.meshBody Mass Index
dc.subject.meshCohort Studies
dc.subject.meshFatty Acid-Binding Proteins - blood
dc.subject.meshGene Expression Regulation
dc.subject.meshHumans
dc.subject.meshInsulin - metabolism
dc.subject.meshInsulin Resistance
dc.subject.meshMale
dc.subject.meshMetabolic Syndrome X - metabolism
dc.subject.meshMiddle Aged
dc.subject.meshOxygen - metabolism
dc.subject.meshPolysomnography - methods
dc.subject.meshSleep Apnea, Obstructive - blood - diagnosis
dc.subjectChemicals And Cas Registry Numbers
dc.titleSerum adipocyte-fatty acid binding protein level is elevated in severe OSA and correlates with insulin resistance
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong