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Article: Serum adipocyte-fatty acid binding protein level is elevated in severe OSA and correlates with insulin resistance

TitleSerum adipocyte-fatty acid binding protein level is elevated in severe OSA and correlates with insulin resistance
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2009
PublisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com
Citation
European Respiratory Journal, 2009, v. 33 n. 2, p. 346-351 How to Cite?
Abstract
Obstructive sleep apnoea (OSA) is associated with insulin resistance and metabolic syndrome. There is evidence that adipocyte-fatty acid binding protein (A-FABP) may be involved in the development of cardiometabolic dysfunction. The present authors hypothesise that A-FABP is upregulated in OSA. A total of 124 males without hypertension, diabetes mellitus, hyperlipidaemia or cardiovascular disease were recruited and underwent polysomnography. Serum A-FABP levels showed significant positive correlations with duration of oxygen desaturation and minimal oxygen saturation, fasting insulin and insulin resistance index by homeostasis model assessment. When subjects were divided into tertiles according to apnoea/hypopnoea index (AHI), serum A-FABP levels were significantly higher in the group with AHI ≥34.4 eventsh-1 than the groups with AHI 13.2-34.4 eventsh-1 or with AHI <13.2 eventsh-1. Serum A-FABP levels were significantly higher in the AHI ≥34.4 group than obesity-matched subjects with AHI <34.4 eventsh-1. Serum adipocyte-fatty acid binding protein levels correlated with obstructive sleep apnoea and insulin resistance, independently of obesity, and were significantly higher in severe obstructive sleep apnoea. Adipocyte-fatty acid binding protein may play a role in obstructive sleep apnoea and metabolic dysfunction. Copyright © ERS Journals Ltd 2009.
Persistent Identifierhttp://hdl.handle.net/10722/91477
ISSN
2013 Impact Factor: 7.125
ISI Accession Number ID
Funding AgencyGrant Number
Research Grants Council (RGC) Earmarked Competitive Grant award7667/07M
RGC Central AllocationHKU 2/07C
Lee Wing Tat Cardiorespiratory Research Fund
Funding Information:

This study was jointly supported by the Research Grants Council (RGC) Earmarked Competitive Grant award 7667/07M, the RGC Central Allocation Grant (HKU 2/07C) and the Lee Wing Tat Cardiorespiratory Research Fund.

References
Grants

 

Author Affiliations
  1. The University of Hong Kong
DC FieldValueLanguage
dc.contributor.authorLam, DCLen_HK
dc.contributor.authorXu, Aen_HK
dc.contributor.authorLam, KSLen_HK
dc.contributor.authorLam, Ben_HK
dc.contributor.authorLam, JCMen_HK
dc.contributor.authorLui, MMSen_HK
dc.contributor.authorIp, MSMen_HK
dc.date.accessioned2010-09-17T10:20:03Z-
dc.date.available2010-09-17T10:20:03Z-
dc.date.issued2009en_HK
dc.identifier.citationEuropean Respiratory Journal, 2009, v. 33 n. 2, p. 346-351en_HK
dc.identifier.issn0903-1936en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91477-
dc.description.abstractObstructive sleep apnoea (OSA) is associated with insulin resistance and metabolic syndrome. There is evidence that adipocyte-fatty acid binding protein (A-FABP) may be involved in the development of cardiometabolic dysfunction. The present authors hypothesise that A-FABP is upregulated in OSA. A total of 124 males without hypertension, diabetes mellitus, hyperlipidaemia or cardiovascular disease were recruited and underwent polysomnography. Serum A-FABP levels showed significant positive correlations with duration of oxygen desaturation and minimal oxygen saturation, fasting insulin and insulin resistance index by homeostasis model assessment. When subjects were divided into tertiles according to apnoea/hypopnoea index (AHI), serum A-FABP levels were significantly higher in the group with AHI ≥34.4 eventsh-1 than the groups with AHI 13.2-34.4 eventsh-1 or with AHI <13.2 eventsh-1. Serum A-FABP levels were significantly higher in the AHI ≥34.4 group than obesity-matched subjects with AHI <34.4 eventsh-1. Serum adipocyte-fatty acid binding protein levels correlated with obstructive sleep apnoea and insulin resistance, independently of obesity, and were significantly higher in severe obstructive sleep apnoea. Adipocyte-fatty acid binding protein may play a role in obstructive sleep apnoea and metabolic dysfunction. Copyright © ERS Journals Ltd 2009.en_HK
dc.languageengen_HK
dc.publisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.comen_HK
dc.relation.ispartofEuropean Respiratory Journalen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAnthropometry - methodsen_HK
dc.subject.meshBody Mass Indexen_HK
dc.subject.meshCohort Studiesen_HK
dc.subject.meshFatty Acid-Binding Proteins - blooden_HK
dc.subject.meshGene Expression Regulationen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInsulin - metabolismen_HK
dc.subject.meshInsulin Resistanceen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMetabolic Syndrome X - metabolismen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshOxygen - metabolismen_HK
dc.subject.meshPolysomnography - methodsen_HK
dc.subject.meshSleep Apnea, Obstructive - blood - diagnosisen_HK
dc.titleSerum adipocyte-fatty acid binding protein level is elevated in severe OSA and correlates with insulin resistanceen_HK
dc.typeArticleen_HK
dc.identifier.emailLam, DCL:lamcl@hkucc.hku.hken_HK
dc.identifier.emailXu, A:amxu@hkucc.hku.hken_HK
dc.identifier.emailLam, KSL:ksllam@hku.hken_HK
dc.identifier.emailIp, MSM:msmip@hku.hken_HK
dc.identifier.authorityLam, DCL=rp01345en_HK
dc.identifier.authorityXu, A=rp00485en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.identifier.authorityIp, MSM=rp00347en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1183/09031936.50075408en_HK
dc.identifier.pmid19181913en_HK
dc.identifier.scopuseid_2-s2.0-59649105053en_HK
dc.identifier.hkuros155048-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-59649105053&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume33en_HK
dc.identifier.issue2en_HK
dc.identifier.spage346en_HK
dc.identifier.epage351en_HK
dc.identifier.eissn1399-3003-
dc.identifier.isiWOS:000263709300018-
dc.publisher.placeSwitzerlanden_HK
dc.relation.projectVascular dysfunction in obesity and diabetes: from risk prediction to therapeutic intervention-
dc.identifier.scopusauthoridLam, DCL=7201749615en_HK
dc.identifier.scopusauthoridXu, A=7202655409en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK
dc.identifier.scopusauthoridLam, B=9246012800en_HK
dc.identifier.scopusauthoridLam, JCM=25923453500en_HK
dc.identifier.scopusauthoridLui, MMS=26027035000en_HK
dc.identifier.scopusauthoridIp, MSM=7102423259en_HK

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