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Article: Microsatellite alterations in squamous cell carcinoma of the head and neck - Clustering of loss of heterozygosity in a distinct subset

TitleMicrosatellite alterations in squamous cell carcinoma of the head and neck - Clustering of loss of heterozygosity in a distinct subset
Authors
Issue Date2000
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/oraloncology
Citation
Oral Oncology, 2000, v. 36 n. 5, p. 484-490 How to Cite?
AbstractLoss of heterozygosity (LOH) and microsatellite instability (MSI) have been recognized as important events in the carcinogenesis of many cancers, including squamous cell carcinoma of head and neck (SCCHN). However, microsatellite alterations have not been documented in SCCHN from Chinese patients. We investigated the frequency and clinical significance of LOH and MSI in 30 SCCHN from Hong Kong Chinese using polymerase chain reaction on 17 microsatellite markers on chromosomes 3p, 4q, 7q, 9p, 17p and 18q. LOH was present in nine tumours (30%) and MSI in four (13%). The incidence of LOH (7/13; 53.8%) in hypopharyngeal-laryngeal cancers was significantly higher than that (2/17; 11.8%) in the oral cancers (P = 0.020). LOH was more often detected at the loci on chromosomes 7 and 9. Patients with tumours having LOH had slightly poorer outcome compared with those without, although the differences did not reach statistical significance. Our data show that the incidence of microsatellite alterations in SCCHN from Hong Kong Chinese is low. However, LOH may be one of the genetic mechanisms in the carcinogenesis of a subset of SCCHN (hypopharyngeal-laryngeal cancers). (C) 2000 Elsevier Science Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/88826
ISSN
2015 Impact Factor: 4.286
2015 SCImago Journal Rankings: 1.764
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNg, IOLen_HK
dc.contributor.authorXiao, Len_HK
dc.contributor.authorLam, KYen_HK
dc.contributor.authorYuen, PWen_HK
dc.contributor.authorNg, Men_HK
dc.date.accessioned2010-09-06T09:48:30Z-
dc.date.available2010-09-06T09:48:30Z-
dc.date.issued2000en_HK
dc.identifier.citationOral Oncology, 2000, v. 36 n. 5, p. 484-490en_HK
dc.identifier.issn1368-8375en_HK
dc.identifier.urihttp://hdl.handle.net/10722/88826-
dc.description.abstractLoss of heterozygosity (LOH) and microsatellite instability (MSI) have been recognized as important events in the carcinogenesis of many cancers, including squamous cell carcinoma of head and neck (SCCHN). However, microsatellite alterations have not been documented in SCCHN from Chinese patients. We investigated the frequency and clinical significance of LOH and MSI in 30 SCCHN from Hong Kong Chinese using polymerase chain reaction on 17 microsatellite markers on chromosomes 3p, 4q, 7q, 9p, 17p and 18q. LOH was present in nine tumours (30%) and MSI in four (13%). The incidence of LOH (7/13; 53.8%) in hypopharyngeal-laryngeal cancers was significantly higher than that (2/17; 11.8%) in the oral cancers (P = 0.020). LOH was more often detected at the loci on chromosomes 7 and 9. Patients with tumours having LOH had slightly poorer outcome compared with those without, although the differences did not reach statistical significance. Our data show that the incidence of microsatellite alterations in SCCHN from Hong Kong Chinese is low. However, LOH may be one of the genetic mechanisms in the carcinogenesis of a subset of SCCHN (hypopharyngeal-laryngeal cancers). (C) 2000 Elsevier Science Ltd.en_HK
dc.languageengen_HK
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/oraloncologyen_HK
dc.relation.ispartofOral Oncologyen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshCarcinoma, Squamous Cell - ethnology - genetics - pathologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHong Kong - ethnologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLoss of Heterozygosity - geneticsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMicrosatellite Repeats - geneticsen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMouth Neoplasms - ethnology - genetics - pathologyen_HK
dc.subject.meshPolymerase Chain Reaction - methodsen_HK
dc.subject.meshSmoking - adverse effectsen_HK
dc.subject.meshSurvival Analysisen_HK
dc.titleMicrosatellite alterations in squamous cell carcinoma of the head and neck - Clustering of loss of heterozygosity in a distinct subseten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1368-8375&volume=36&spage=484&epage=490&date=2000&atitle=Microsatellite+alterations+in+squamous+cell+carcinoma+of+the+head+and+neck+-+clustering+of+loss+of+heterozygosity+in+a+distinct+subseten_HK
dc.identifier.emailNg, IOL:iolng@hkucc.hku.hken_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S1368-8375(00)00040-3en_HK
dc.identifier.pmid10964058-
dc.identifier.scopuseid_2-s2.0-0033842102en_HK
dc.identifier.hkuros56455en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033842102&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume36en_HK
dc.identifier.issue5en_HK
dc.identifier.spage484en_HK
dc.identifier.epage490en_HK
dc.identifier.isiWOS:000088955900014-
dc.publisher.placeUnited Kingdomen_HK

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